Glucose turnover, fuel oxidation and forearm substrate exchange in patients with thyrotoxicosis before and after medical treatment

1996 ◽  
Vol 44 (4) ◽  
pp. 453-459 ◽  
Author(s):  
Niels Møller ◽  
Søren Nielsen ◽  
Birgit Nyholm ◽  
Niels Pørksen ◽  
K. George ◽  
...  
Keyword(s):  
Medical Treatment ◽  
Glucose Turnover ◽  
Fuel Oxidation ◽  
Before And After

Comparison of 24-Hour Electrocardiogram Parameters in Patients with Graves Disease Before and After Anti-Thyroid Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Gamze Akkuş ◽  
Yeliz Sökmen ◽  
Mehmet Yılmaz ◽  
Özkan Bekler ◽  
Oğuz Akkuş
Keyword(s):  
Treatment Group ◽  
Medical Treatment ◽  
Surgical Therapy ◽  
Graves Disease ◽  
Before And After ◽  
Euthyroid Status ◽  
Ectopic Beats ◽  
Group 2 ◽  
Electrocardiographic Parameters ◽  
Group 1

Background: We aimed prospectively investigate the laboratory and electrocardiographic parameters (hearth rate, QRS, QT, QTc, Tpe, Tpe/QTc, arrhythmia prevalance) in patients with graves disease before and after antithyroid therapy. Methods: 71 patients (48 female, 23 male), age between 18-50 (mean±SD: 36.48±12.20 ) with GD were included into the study. Patients treated with antithyroid therapy (thionamids and/or surgical therapy) to maintain euthyroid status. Patients were examined in terms of electrocardiographic parameters before and after the treatment. Results: Mean TSH, free thyroxin (fT4) and tri-iodothyrionine (fT3) levels of all patients were 0.005±0.21, 3.27± 1.81, 11.42±7.44, respectively. While 9 patients (group 2) underwent surgical therapy, had suspicious of malignant nodule or large goiter and unresponsiveness to medical treatment; the other patients (n=62, group 1) were treated with medical therapy. Patients with surgical therapy had more increased serum fT4 (p=0.045), anti-thyroglobulin value (p=0.018) and more severe graves orbitopathy (n=0.051) before treatment when compared to medical therapy group. Baseline Tpe duration and baseline Tpe/QTc ratio and frequency of supraventricular ectopic beats were found to be significantly higher in group 2 when compared to group 1 (p=0.00, p=0.005). Otherwise baseline mean heart rate, QRS duration, QTc values of both groups were similar. Although the patients became their euthyroid status, group 2 patients had still suffered from more sustained supraventricular ectopics beats than group 1. Conclusion: Distinct from medical treatment group, surgical treatment group with euthyroidism at least 3 months had still suffered from an arrhythmia (Tpe, Tpe/QTc, supraventricular and ventricular ectopic beats).

scholarly journals Levels of Patient Satisfaction on Integrative Medicine Before and After Implementation of Diagnosis-related Groups

2018 ◽  
Vol 7 ◽  
pp. 216495611875925 ◽  
Author(s):  
Tobias Romeyke ◽  
Elisabeth Noehammer ◽  
Hans Christoph Scheuer ◽  
Harald Stummer
Keyword(s):  
Patient Satisfaction ◽  
Medical Treatment ◽  
Diagnosis Related Groups ◽  
Hospital Setting ◽  
Nutrition Therapy ◽  
Study Patient ◽  
Patient Centered ◽  
General Evaluation ◽  
Conventional Medical Treatment ◽  
Before And After

Objectives The aim of this article is to study patient satisfaction with complementary and alternative medicine (CAM) in an in-hospital setting before and after the introduction of diagnosis-related groups (DRGs). Methods Patients were interviewed regarding a general evaluation of their hospital stay, the psychological talking therapy, the nutrition therapy, and the overall success of the treatment. Results The medical treatment was evaluated by 1158 patients. A very good success was reported by 347, a good by 609, a moderate by 181, and none by 21 patients. DRG implementation showed no significant effects. Psychological talking therapy was evaluated as “very good” ( P ≤ .05). With regard to the success of the medical talking and nutrition therapy, there were no significant differences ( P ≥ .05) between the time before and after DRG implementation. Conclusion Broadening conventional medical treatment with CAM practices can lead to a parallel treatment of DRGs in hospitals working with complementary medicine. This results in very patient-centered therapies, which may impact patient satisfaction.

scholarly journals Effect of Increasing Glutathione With Cysteine and Glycine Supplementation on Mitochondrial Fuel Oxidation, Insulin Sensitivity, and Body Composition in Older HIV-Infected Patients

2014 ◽  
Vol 99 (1) ◽  
pp. 169-177 ◽  
Author(s):  
Dan Nguyen ◽  
W Hsu Jean ◽  
Farook Jahoor ◽  
V Sekhar Rajagopal
Keyword(s):  
Body Composition ◽  
Insulin Sensitivity ◽  
Muscle Strength ◽  
Acid Oxidation ◽  
Open Label ◽  
Metabolic Complications ◽  
Fuel Oxidation ◽  
Oral Supplementation ◽  
Isotope Tracers ◽  
Before And After

Abstract Background HIV-infected patients are reported to have impaired oxidation of fatty acids despite increased availability, suggesting a mitochondrial defect. We investigated whether diminished levels of a key mitochondrial antioxidant, glutathione (GSH), was contributing to defective fatty acid oxidation in older HIV-infected patients, and if so, the metabolic mechanisms contributing to GSH deficiency in these patients. Methods In an open-label design, 8 older GSH-deficient HIV-infected males were studied before and after 14 days of oral supplementation with the GSH precursors cysteine and glycine. A combination of stable-isotope tracers, calorimetry, hyperinsulinemic-euglycemic clamp, and dynamometry were used to measure GSH synthesis, fasted and insulin-stimulated (fed) mitochondrial fuel oxidation, insulin sensitivity, body composition, anthropometry, forearm-muscle strength, and lipid profiles. Results Impaired synthesis contributed to GSH deficiency in the patients and was restored with cysteine plus glycine supplementation. GSH improvement was accompanied by marked improvements in fasted and fed mitochondrial fuel oxidation. Associated benefits included improvements in insulin sensitivity, body composition, anthropometry, muscle strength, and dyslipidemia. Conclusions This work identifies 2 novel findings in older HIV-infected patients: 1) diminished synthesis due to decreased availability of cysteine and glycine contributes to GSH deficiency and can be rapidly corrected by dietary supplementation of these precursors and 2) correction of GSH deficiency is associated with improvement of mitochondrial fat and carbohydrate oxidation in both fasted and fed states and with improvements in insulin sensitivity, body composition, and muscle strength. The role of GSH on ameliorating metabolic complications in older HIV-infected patients warrants further investigation. (J Clin Endocrinol Metab 99: 169–177, 2014)

Muscle strength in hyperthyroid patients before and after medical treatment

1990 ◽  
Vol 10 (6) ◽  
pp. 545-550 ◽  
Author(s):  
F. Celsing ◽  
S. H. Westing ◽  
U. Adamson ◽  
B. Ekblom
Keyword(s):  
Muscle Strength ◽  
Medical Treatment ◽  
Before And After ◽  
Hyperthyroid Patients

Treatment Efficacy

1998 ◽  
Vol 41 (1) ◽  
Author(s):  
Lorraine Olson Ramig ◽  
Katherine Verdolini
Keyword(s):  
Medical Treatment ◽  
Voice Disorders ◽  
Voice Disorder ◽  
Future Research ◽  
Vocal Health ◽  
Physical Conditions ◽  
Voice Treatment ◽  
Before And After ◽  
The Voice

This article reviews the literature on the efficacy of treatment for voice disorders primarily using studies published in peer-reviewed journals. Voice disorders are defined, their frequency of occurrence across the life span is reported, and their impact on the lives of individuals with voice disorders is documented. The goal of voice treatment is to maximize vocal effectiveness given the existing disorder and to reduce the handicapping effect of the voice problem. Voice treatment may be (a) the preferred treatment to resolve the voice disorder when medical (surgical or pharmacological) treatments are not indicated; (b) the initial treatment in cases where medical treatment appears indicated; it may obviate the need for medical treatment; (c) completed before and after surgical treatment to maximize long-term post-surgical voice; and (d) a preventative treatment to preserve vocal health. Experimental and clinical data are reviewed that support these roles applied to various disorder types: (a) vocal misuse, hyperfunction and muscular imbalance (frequently resulting in edema, vocal nodules, polyps or contact ulcers); (b) medical or physical conditions (e.g., laryngeal nerve trauma, Parkinson disease); and (c) psychogenic disorders (e.g., conversion reactions, personality disorders). Directions for future research are suggested which maximize clinical outcomes and scientific rigor to enhance knowledge on the efficacy of voice treatment.

Non-Inflammatory Pathologies of Conjunctiva

2022 ◽  
pp. 102-136
Keyword(s):  
Medical Treatment ◽  
Intraepithelial Neoplasia ◽  
Underlying Disease ◽  
Surgical Interventions ◽  
Anatomical Changes ◽  
Before And After ◽  
Conjunctival Lymphoma

Non-inflammatory pathologies of conjunctiva refer to conjunctival diseases or conditions that do not have infectious or immune inflammatory origin. This chapter includes disorders such as conjunctivochalasis, conjunctival cysts, conjunctival lymphangiectasias, conjunctival lymphoma, dermoids, papilloma, intraepithelial neoplasia, nevi and other rarely seen tumors, conjunctival degenerations and changes related to aging, xerosis, as well as interesting cases of fastidious conjunctivitis. Some cases of neoplasia have before and after treatment illustration to highlight the possibility of medical treatment against surgical interventions. At the end of this chapter, some observations are added to show the anatomical changes of conjunctiva without any underlying disease or inflammation.

Endurance training decreases plasma glucose turnover and oxidation during moderate-intensity exercise in men

1990 ◽  
Vol 68 (3) ◽  
pp. 990-996 ◽  
Author(s):  
A. R. Coggan ◽  
W. M. Kohrt ◽  
R. J. Spina ◽  
D. M. Bier ◽  
J. O. Holloszy
Keyword(s):  
Endurance Training ◽  
Plasma Glucose ◽  
Cycle Ergometer ◽  
Fat Free Mass ◽  
Strenuous Exercise ◽  
Moderate Intensity ◽  
Glucose Turnover ◽  
Moderate Intensity Exercise ◽  
Ergometer Exercise ◽  
Before And After

To assess the effects of endurance training on plasma glucose kinetics during moderate-intensity exercise in men, seven men were studied before and after 12 wk of strenuous exercise training (3 days/wk running, 3 days/wk cycling). After priming of the glucose and bicarbonate pools, [U-13C] glucose was infused continuously during 2 h of cycle ergometer exercise at 60% of pretraining peak O2 uptake (VO2) to determine glucose turnover and oxidation. Training increased cycle ergometer peak VO2 by 23% and decreased the respiratory exchange ratio during the final 30 min of exercise from 0.89 +/- 0.01 to 0.85 +/- 0.01 (SE) (P less than 0.001). Plasma glucose turnover during exercise decreased from 44.6 +/- 3.5 mumol.kg fat-free mass (FFM)-1.min-1 before training to 31.5 +/- 4.3 after training (P less than 0.001), whereas plasma glucose clearance (i.e., rate of disappearance/plasma glucose concentration) fell from 9.5 +/- 0.6 to 6.4 +/- 0.8 ml.kg FFM-1.min-1 (P less than 0.001). Oxidation of plasma-derived glucose, which accounted for approximately 90% of plasma glucose disappearance in both the untrained and trained states, decreased from 41.1 +/- 3.4 mumol.kg FFM-1.min-1 before training to 27.7 +/- 4.8 after training (P less than 0.001). This decrease could account for roughly one-half of the total reduction in the amount of carbohydrate utilized during the final 30 min of exercise in the trained compared with the untrained state.

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