scholarly journals Minireview: Thyrotropin-Releasing Hormone and the Thyroid Hormone Feedback Mechanism

2009 ◽  
Vol 94 (4) ◽  
pp. 1472-1472
Author(s):  
Maria Izabel Chiamolera ◽  
Fredric E. Wondisford
Keyword(s):  
Thyroid Hormone ◽  
Feedback Mechanism ◽  
Thyrotropin Releasing Hormone ◽  
Releasing Hormone

scholarly journals Aberrant Dynamics of Histone Deacetylation at the Thyrotropin-Releasing Hormone Gene in Resistance to Thyroid Hormone

2004 ◽  
Vol 18 (7) ◽  
pp. 1708-1720 ◽  
Author(s):  
S. Ishii ◽  
M. Yamada ◽  
T. Satoh ◽  
T. Monden ◽  
K. Hashimoto ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Histone Deacetylation ◽  
Resistance To Thyroid Hormone ◽  
Releasing Hormone

Differential regulation of thyrotropin-releasing hormone receptor mRNA levels by thyroid hormone in vivo and in vitro (GH3 cells)

1992 ◽  
Vol 184 (1) ◽  
pp. 367-372 ◽  
Author(s):  
Masanobu Yamada ◽  
Tuyoshi Monden ◽  
Teturou Satoh ◽  
Masahiko Iizuka ◽  
Masami Murakami ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Differential Regulation ◽  
Thyrotropin Releasing Hormone ◽  
Gh3 Cells ◽  
Mrna Levels ◽  
Releasing Hormone ◽  
Receptor Mrna

Familial Partial Peripheral and Pituitary Resistance to Thyroid Hormone: A Frequently Missed Diagnosis?

PEDIATRICS ◽  
1986 ◽  
Vol 78 (6) ◽  
pp. 1114-1122
Author(s):  
Nancy J. Hopwood ◽  
Sue Ellyn Sauder ◽  
Brahm Shapiro ◽  
James C. Sisson
Keyword(s):  
Thyroid Hormone ◽  
Family Members ◽  
Elevated Serum ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Resistance To Thyroid Hormone ◽  
Releasing Hormone ◽  
Thyroxine Therapy ◽  
Missed Diagnosis ◽  
Serum Tsh

The diagnosis of partial peripheral and pituitary resistance to thyroid hormone was ultimately made in two boys, 7 and 9 years of age, and a 10-year-old girl who had goiters and hyperthyroxinemia. The boys were treated with propythiouracil and/or thyroidectomy or iodine 131 for suspected thyrotoxicosis but had poorly suppressible serum thyroid-stimulating hormone (TSH) post treatment in spite of the usual L-thyroxine replacement. The girl had increasing goiter size while receiving propylthiouracil, 100 mg every eight hours. These findings led to reevaluation of thyroid hormone dynamics in these children and their families. Twelve additional family members, 3 to 38 years of age, compatible with an autosomal dominant inheritance, were also found to have peripheral and pituitary resistance to thyroid hormone. All affected individuals had elevated serum thyroxine and triiodothyronine levels, normal to slightly elevated triiodothyronine resin uptakes, and a nonsuppressed serum TSH. The five individuals who were given thyrotropin-releasing hormone showed exaggerated TSH responses, which normalized on L-thyroxine therapy. Misdiagnosis in six of 15 family members led to significant morbidity (hypothyroidism, delayed growth, and therapy risk). A nonsuppressed serum TSH in a patient with suspected thyrotoxicosis should lead to suspicion of this disorder. Appropriate management for this condition includes L-thyroxine therapy to decrease goiter size and normalize TSH responses to thyrotropin-releasing hormone.

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