scholarly journals Functional Characterization of the Human Resistin Promoter with Adipocyte Determination- and Differentiation-Dependent Factor 1/Sterol Regulatory Element Binding Protein 1c and CCAAT Enhancer Binding Protein-α

2003 ◽  
Vol 17 (8) ◽  
pp. 1522-1533 ◽  
Author(s):  
Jong Bae Seo ◽  
Mun Ju Noh ◽  
Eung Jae Yoo ◽  
So Yun Park ◽  
Jiyoung Park ◽  
...  
Keyword(s):  
Binding Protein ◽  
Regulatory Element ◽  
Functional Characterization ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Human Resistin ◽  
Dependent Factor

Characterization of Cleavage Enzymes for Sterol Regulatory Element Binding Protein in Hamster Liver Microsomes

1999 ◽  
Vol 258 (3) ◽  
pp. 542-547 ◽  
Author(s):  
Mineko Yamaguchi ◽  
Heigoro Shirai ◽  
Ryuichiro Sato ◽  
Yoshiki Kawabe ◽  
Rie Fukuda ◽  
...  
Keyword(s):  
Binding Protein ◽  
Regulatory Element ◽  
Liver Microsomes ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

Characterization of cleavage enzymes for sterol regulatory element binding protein

2000 ◽  
Vol 151 (1) ◽  
pp. 289-290
Author(s):  
M. Yamaguchi ◽  
H. Shirai ◽  
G. Ishihara ◽  
R. Sato ◽  
Y. Kawabe ◽  
...  
Keyword(s):  
Binding Protein ◽  
Regulatory Element ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

scholarly journals Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection

1995 ◽  
Vol 270 (49) ◽  
pp. 29422-29427 ◽  
Author(s):  
Xianxin Hua ◽  
Juro Sakai ◽  
Ho Y. K. ◽  
Joseph L. Goldstein ◽  
Michael S. Brown
Keyword(s):  
Cell Membranes ◽  
Binding Protein ◽  
Regulatory Element ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

scholarly journals Sterol Regulatory Element Binding Protein 1a Regulates Hepatic Fatty Acid Partitioning by Activating Acetyl Coenzyme A Carboxylase 2

2009 ◽  
Vol 29 (17) ◽  
pp. 4864-4872 ◽  
Author(s):  
Seung-Soon Im ◽  
Linda E. Hammond ◽  
Leyla Yousef ◽  
Cherryl Nugas-Selby ◽  
Dong-Ju Shin ◽  
...  
Keyword(s):  
Insertional Mutagenesis ◽  
Coenzyme A ◽  
Binding Protein ◽  
Regulatory Element ◽  
Fatty Acyl ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Microarray Expression

ABSTRACT We generated a line of mice in which sterol regulatory element binding protein 1a (SREBP-1a) was specifically inactivated by insertional mutagenesis. Homozygous mutant mice were completely viable despite expressing SREBP-1a mRNA below 5% of normal, and there were minimal effects on expression of either SREBP-1c or -2. Microarray expression studies in liver, where SREBP-1a mRNA is 1/10 the level of the highly similar SREBP-1c, demonstrated that only a few genes were affected. The only downregulated genes directly linked to lipid metabolism were Srebf1 (which encodes SREBP-1) and Acacb (which encodes acetyl coenzyme A [acetyl-CoA] carboxylase 2 [ACC2], a critical regulator of fatty acyl-CoA partitioning between cytosol and mitochondria). ACC2 regulation is particularly important during food restriction. Similar to Acacb knockout mice, SREBP-1a-deficient mice have lower hepatic triglycerides and higher serum ketones during fasting than wild-type mice. SREBP-1a and -1c have identical DNA binding and dimerization domains; thus, the failure of the more abundant SREBP-1c to substitute for activating hepatic ACC2 must relate to more efficient recruitment of transcriptional coactivators to the more potent SREBP-1a activation domain. Our chromatin immunoprecipitation results support this hypothesis.

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