scholarly journals The Effect of Thyroid Hormone on the Chromatin Structure and Expression of the Malic Enzyme Gene in Hepatocytes

1988 ◽  
Vol 2 (7) ◽  
pp. 619-626 ◽  
Author(s):  
Stephen J. Usala ◽  
W. Scott Young ◽  
Hajimu Morioka ◽  
Vera M. Nikodem
Keyword(s):  
Thyroid Hormone ◽  
Chromatin Structure ◽  
Malic Enzyme ◽  
Enzyme Gene ◽  
Malic Enzyme Gene

scholarly journals Hexachlorobenzene, a Dioxin-Type Compound, Increases Malic Enzyme Gene Transcription through a Mechanism Involving the Thyroid Hormone Response Element1

Endocrinology ◽  
1999 ◽  
Vol 140 (9) ◽  
pp. 4142-4151 ◽  
Author(s):  
Andrea I. Loaiza-Pérez ◽  
Maria-Teresa Seisdedos ◽  
Diana L. Kleiman de Pisarev ◽  
Horacio A. Sancovich ◽  
Andrea S. Randi ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Gene Transcription ◽  
Malic Enzyme ◽  
Hormone Response ◽  
Enzyme Gene ◽  
Type Compound ◽  
Malic Enzyme Gene

scholarly journals Thyromimetic mode of action of peroxisome proliferators: activation of ‘malic’ enzyme gene transcription

1996 ◽  
Vol 319 (1) ◽  
pp. 241-248 ◽  
Author(s):  
Rachel HERTZ ◽  
Vera NIKODEM ◽  
Alumit BEN-ISHAI ◽  
Inna BERMAN ◽  
Jacob BAR-TANA
Keyword(s):  
Thyroid Hormone ◽  
Transcriptional Activation ◽  
Malic Enzyme ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferators ◽  
Peroxisome Proliferator Activated Receptor ◽  
Enzyme Gene ◽  
Hormone Response Element ◽  
Malic Enzyme Gene ◽  
Glycerol 3 Phosphate Dehydrogenase

Peroxisome proliferators induce thyroid-hormone-dependent liver activities, e.g. ‘malic’ enzyme, mitochondrial glycerol-3-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase, S14 [Hertz, Aurbach, Hashimoto and Bar-Tana (1991) Biochem. J. 274, 745–751]. Here we report that the thyromimetic effect of peroxisome proliferators with respect to ‘malic’ enzyme results from transcriptional activation of the ‘malic’ enzyme gene, mediated by binding of the peroxisome proliferator activated receptor (PPARα)/retinoid X receptor (RXRα) heterodimer to a 5´-flanking enhancer of the ‘malic’ enzyme promoter. The enhancer involved is distinct from the thyroid hormone response element of the ‘malic’ enzyme promoter and is partly homologous with that which mediates transcriptional activation of peroxisomal acyl-CoA oxidase by peroxisome proliferators. Hence transcriptional activation of thyroid-hormone-dependent liver genes by xenobiotic or endogenous amphipathic carboxylates collectively defined as peroxisome proliferators is mediated by a transduction pathway similar to that involved in transcriptional activation of peroxisomal β-oxidative genes and distinct from that which mediates thyroid hormone action.

Characterization of the NADP malic enzyme gene family in the facultative, single-cell C4 monocot Hydrilla verticillata

2007 ◽  
Vol 94 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Gonzalo M. Estavillo ◽  
Srinath K. Rao ◽  
Julia B. Reiskind ◽  
George Bowes
Keyword(s):  
Gene Family ◽  
Single Cell ◽  
Malic Enzyme ◽  
Hydrilla Verticillata ◽  
Enzyme Gene ◽  
Malic Enzyme Gene
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