The increased intestinal absorption rate is responsible for the reduced hepatic first-pass extraction of propranolol in rats with cisplatin-induced renal dysfunction

2003 ◽  
Vol 55 (4) ◽  
pp. 479-486 ◽  
Author(s):  
Hiromi Okabe ◽  
Akiko Mizukami ◽  
Masato Taguchi ◽  
Tetsuya Aiba ◽  
Masato Yasuhara ◽  
...  
Keyword(s):  
Renal Dysfunction ◽  
Intestinal Absorption ◽  
Absorption Rate ◽  
First Pass

scholarly journals Intestinal Absorption and First-Pass Elimination of 2',3'-Dideoxynucleosides Following Oral Administration in Rats.

1996 ◽  
Vol 19 (4) ◽  
pp. 599-603 ◽  
Author(s):  
Tetsuya HASEGAWA ◽  
Kazuhiko JUNI ◽  
Mineo SANEYOSHI ◽  
Takeo KAWAGUCHI
Keyword(s):  
Oral Administration ◽  
Intestinal Absorption ◽  
First Pass

scholarly journals First-Pass Metabolism Limits the Intestinal Absorption of Enteral α-Ketoglutarate in Young Pigs

2006 ◽  
Vol 136 (11) ◽  
pp. 2779-2784 ◽  
Author(s):  
Barry D. Lambert ◽  
Rafal Filip ◽  
Barbara Stoll ◽  
Peter Junghans ◽  
Michael Derno ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Young Pigs ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism

scholarly journals Absorption of inorganic, trivalent and hexavalent chromium following oral and intrajejunal doses in rats

2001 ◽  
Vol 49 (2) ◽  
pp. 203-209 ◽  
Author(s):  
Hedvig Fébel ◽  
B. Szegedi ◽  
Szilvia Huszár
Keyword(s):  
Intestinal Absorption ◽  
Hexavalent Chromium ◽  
Absorption Rate ◽  
Water Soluble ◽  
Chromic Oxide ◽  
Sodium Chromate ◽  
Rat Intestine ◽  
Indicator Method ◽  
Lower Blood ◽  
Chromium Compounds

The intestinal absorption of trivalent and hexavalent chromium (Cr) given orally (experiment I) or infused in the intestine (experiment II) was investigated in rats. The nonabsorbable form of chromium (51Cr2O3) and water-soluble and more absorbable Na251CrO4 (the hexavalent form of Cr) were compared. Total retention of chromium given orally ranged around 15 percent of the dose, regardless of the chromium compounds applied. The absorption rate of chromic oxide, which is considered a nonabsorbable compound, was 14.4 as a percentage of chromium intake. This result indicates that some loss of chromium has to be taken into account in metabolic trials made by the indicator method. In isolated rat intestine, from the injected Cr 2.5% of chromic oxide and 43.2% of sodium chromate were absorbed during an hour (experiment II). The absorbed chromium was transferred to the liver where the liver tissue retained 10.9% of chromic oxide and 51.1% of sodium chromate. Radioactivity of v. cava caudalis following intestinal injection of Na2CrO4 was thirtyfold greater than after Na2CrO4 dosing. This phenomenon can be explained by the lower blood clearance of chromate. Different absorption rate of chromate depending on the route of administration could be due to the fact that the hexavalent form given orally was reduced to Cr3+ in the acidic environment of the stomach. When Na2CrO4 was infused directly in the intestine of rats, such reduction could not occur. This means that the acidic gastric juice might play a role in inhibiting the intestinal absorption of Na2CrO4 when this compound is given orally.

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

2010 ◽  
Vol 53 (3) ◽  
pp. 1098-1108 ◽  
Author(s):  
Manthena V. S. Varma ◽  
R. Scott Obach ◽  
Charles Rotter ◽  
Howard R. Miller ◽  
George Chang ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Oral Bioavailability ◽  
Human Intestinal Absorption ◽  
First Pass

scholarly journals In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator

2010 ◽  
Vol 25 (5) ◽  
pp. 477-486 ◽  
Author(s):  
Jing Zhu ◽  
Stephanie Lee ◽  
Maurice K.C. Ho ◽  
Yueqing Hu ◽  
Haihong Pang ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Small Molecule ◽  
Hepatic Metabolism ◽  
First Pass

The ex-vivo intestinal absorption rate of uranium is a two-phase function of supply

2014 ◽  
Vol 69 (2) ◽  
pp. 256-262 ◽  
Author(s):  
Rainer Konietzka ◽  
Rita Heinze ◽  
Margarete Seiwert ◽  
Hermann H. Dieter
Keyword(s):  
Intestinal Absorption ◽  
Phase Function ◽  
Absorption Rate ◽  
Ex Vivo ◽  
Two Phase
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