Intestinal Absorption and First-Pass Elimination of 2',3'-Dideoxynucleosides Following Oral Administration in Rats.

SummaryThe study of calcium metabolism in ten thalassaemic children comperatively with controls after oral administration of 47Ca has shown diminished intestinal absorption. It is suggested that this finding is propably related in part with the pathogenesis of the osteoporosis in thalassaemia.

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Lack of influence of the antidopaminergic drug domperidone on basal and TRH-stimulated TSH-serum levels after oral administration

Acta Endocrinologica ◽

10.1530/acta.0.1010550 ◽

1982 ◽

Vol 101 (4) ◽

pp. 550-554 ◽

Cited By ~ 2

Author(s):

K. W. Wenzel ◽

J. Döring

Keyword(s):

Oral Administration ◽

Thyroid Function ◽

Oral Absorption ◽

Statistical Significance ◽

Oral Intake ◽

Serum Levels ◽

The Novel ◽

Antiemetic Drug ◽

First Pass ◽

The Difference

Abstract. Since antidopaminergic drugs are known to elevate basal and TRH-stimulated TSH-serum levels and since this effect was also shown after iv administration of the novel dopamine antagonistic agent domperidone, it was investigated, whether this antiemetic drug could interfere after oral intake with the evaluation of thyroid function. Oral domperidone caused a marked TSH-enhancement of TRH-induced TSH increments in 6 out of 14 euthyroid subjects, with no statistical significance, however. The difference between oral and parenteral influence as well as inter-individual changes are probably due to the varying first pass effect of the drug after oral absorption.

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Influence of First-Pass Effect on Availability of Drugs on Oral Administration

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600600909 ◽

1971 ◽

Vol 60 (9) ◽

pp. 1338-1340 ◽

Cited By ~ 207

Author(s):

M. Gibaldi ◽

R.N. Boyes ◽

S. Feldman

Keyword(s):

Oral Administration ◽

First Pass Effect ◽

First Pass

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Dose-dependent pharmacokinetics of a new reversible proton pump inhibitor, DBM-819, after intravenous and oral administration to rats: hepatic first-pass effect

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.264 ◽

2001 ◽

Vol 22 (3) ◽

pp. 119-128 ◽

Cited By ~ 2

Author(s):

Eun J. Kim ◽

Sun-O. Kim ◽

Dong H. Lee ◽

Hong Lim ◽

Myung G. Lee

Keyword(s):

Proton Pump Inhibitor ◽

Oral Administration ◽

Proton Pump ◽

First Pass Effect ◽

First Pass ◽

Intravenous And Oral Administration ◽

Dose Dependent

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REVERSAL OF BETAMETHASONE-INDUCED INHIBITION OF INTESTINAL CALCIUM ABSORPTION BY 1α-HYDROXYCHOLECALCIFEROL

Journal of Endocrinology ◽

10.1677/joe.0.0780187 ◽

1978 ◽

Vol 78 (2) ◽

pp. 187-194 ◽

Cited By ~ 7

Author(s):

J. FOX ◽

A. D. CARE ◽

D. H. MARSHALL

Keyword(s):

Absorption Coefficient ◽

Oral Administration ◽

Intestinal Absorption ◽

Calcium Absorption ◽

Mean Value ◽

Intestinal Calcium Absorption ◽

Control Value ◽

Isotope Technique ◽

Intravenous And Oral Administration ◽

Double Isotope

SUMMARY The intestinal absorption of calcium has been studied in conscious, unstressed pigs, using a modification of the double isotope technique. The oral administration of betamethasone (1 mg/day) to four pigs (25–33 kg) for 4 weeks reduced the calcium absorption coefficient, calculated after the intravenous and oral administration of 47Ca2+, by a mean value of 66%. The oral administration of 1α-hydroxycholecalciferol (2 μg/day) in combination with betamethasone (1 mg/day) for a further 4 weeks returned the absorption coefficient to the control value.

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First-Pass Metabolism Limits the Intestinal Absorption of Enteral α-Ketoglutarate in Young Pigs

Journal of Nutrition ◽

10.1093/jn/136.11.2779 ◽

2006 ◽

Vol 136 (11) ◽

pp. 2779-2784 ◽

Cited By ~ 36

Author(s):

Barry D. Lambert ◽

Rafal Filip ◽

Barbara Stoll ◽

Peter Junghans ◽

Michael Derno ◽

...

Keyword(s):

Intestinal Absorption ◽

Young Pigs ◽

First Pass Metabolism ◽

First Pass ◽

Pass Metabolism

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The experimental production of ‘green yolks’ by the oral administration of sodium copper chlorophyllin

The Journal of Agricultural Science ◽

10.1017/s0021859600040296 ◽

1955 ◽

Vol 46 (3) ◽

pp. 384-385 ◽

Cited By ~ 2

Author(s):

Alastair N. Worden ◽

J. Bunyan ◽

A. W. Davies ◽

M. Kleissner

Keyword(s):

Oral Administration ◽

Intestinal Absorption ◽

Gelatin Capsule ◽

Experimental Production ◽

Extraction Procedures ◽

Chlorophyll Derivative ◽

Sodium Copper Chlorophyllin

1. A condition that appears to be identical with ‘green yolks’ as observed in natural cases has been reproduced by the oral administration in gelatin capsule of from 250 to 1000 mg. sodium copper chlorophyllin 100% daily for 4 days upwards to Light Sussex hens in second lay.2. Following suitable extraction procedures the presence of a chlorophyll derivative has been determined spectrophotometrically in the affected yolks.3. Quantities of sodium copper chlorophyllin of the order of 1 mg. have been recovered from affected yolks.4. It is considered that the passage of chlorophyll to the yolk indicates that intestinal absorption has occurred.

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