AUTISM SPECTRUM DISORDERS FOLLOWING IN UTERO EXPOSURE TO ANTIEPILEPTIC DRUGS

Neurology ◽  
2009 ◽  
Vol 73 (12) ◽  
pp. 997-997 ◽  
Author(s):  
M. L. Evatt ◽  
M. R. DeLong ◽  
W. B. Grant ◽  
J. J. Cannell ◽  
V. Tangpricha
Keyword(s):  
Autism Spectrum Disorders ◽  
Antiepileptic Drugs ◽  
In Utero ◽  
Autism Spectrum ◽  
In Utero Exposure ◽  
Spectrum Disorders

scholarly journals AUTISM SPECTRUM DISORDERS FOLLOWING IN UTERO EXPOSURE TO ANTIEPILEPTIC DRUGS

Neurology ◽  
2008 ◽  
Vol 71 (23) ◽  
pp. 1923-1924 ◽  
Author(s):  
R. L. Bromley ◽  
G. Mawer ◽  
J. Clayton-Smith ◽  
G. A. Baker ◽  
Keyword(s):  
Autism Spectrum Disorders ◽  
Antiepileptic Drugs ◽  
In Utero ◽  
Autism Spectrum ◽  
In Utero Exposure ◽  
Spectrum Disorders

In utero Exposure to  -2-Adrenergic Receptor Agonist Drugs and Risk for Autism Spectrum Disorders

PEDIATRICS ◽  
2016 ◽  
Vol 137 (2) ◽  
pp. e20151316-e20151316 ◽  
Author(s):  
N. B. Gidaya ◽  
B. K. Lee ◽  
I. Burstyn ◽  
Y. Michael ◽  
C. J. Newschaffer ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
In Utero ◽  
Autism Spectrum ◽  
In Utero Exposure ◽  
Spectrum Disorders ◽  
Adrenergic Receptor Agonist

scholarly journals Bisphenol A Exposure in utero Disrupts Hypothalamic Gene Expression Particularly Genes Suspected in Autism Spectrum Disorders and Neuron and Hormone Signaling

2020 ◽  
Vol 21 (9) ◽  
pp. 3129
Author(s):  
Anne D. Henriksen ◽  
Alejandro Andrade ◽  
Erin P. Harris ◽  
Emilie F. Rissman ◽  
Jennifer T. Wolstenholme
Keyword(s):  
Gene Expression ◽  
Autism Spectrum Disorders ◽  
Bisphenol A ◽  
In Utero ◽  
Autism Spectrum ◽  
Differentially Expressed ◽  
Basal Nucleus ◽  
Spectrum Disorders ◽  
And Control ◽  
Upstream Regulators

Bisphenol A (BPA) is an endocrine-disrupting compound detected in the urine of more than 92% of humans, easily crosses the placental barrier, and has been shown to influence gene expression during fetal brain development. The purpose of this study was to investigate the effect of in utero BPA exposure on gene expression in the anterior hypothalamus, the basal nucleus of the stria terminalis (BNST), and hippocampus in C57BL/6 mice. Mice were exposed in utero to human-relevant doses of BPA, and then RNA sequencing was performed on male PND 28 tissue from whole hypothalamus (n = 3/group) that included the medial preoptic area (mPOA) and BNST to determine whether any genes were differentially expressed between BPA-exposed and control mice. A subset of genes was selected for further study using RT-qPCR on adult tissue from hippocampus to determine whether any differentially expressed genes (DEGs) persisted into adulthood. Two different RNA-Seq workflows indicated a total of 259 genes that were differentially expressed between BPA-exposed and control mice. Gene ontology analysis indicated that those DEGs were overrepresented in categories relating to mating, cell–cell signaling, behavior, neurodevelopment, neurogenesis, synapse formation, cognition, learning behaviors, hormone activity, and signaling receptor activity, among others. Ingenuity Pathway Analysis was used to interrogate novel gene networks and upstream regulators, indicating the top five upstream regulators as huntingtin, beta-estradiol, alpha-synuclein, Creb1, and estrogen receptor (ER)-alpha. In addition, 15 DE genes were identified that are suspected in autism spectrum disorders.

In utero exposure to antiepileptic drugs is associated with learning disabilities among offspring

2018 ◽  
Vol 89 (12) ◽  
pp. 1324-1331 ◽  
Author(s):  
Laura Fuglsang Bech ◽  
Christoffer Polcwiartek ◽  
Kristian Kragholm ◽  
Mikkel Porsborg Andersen ◽  
Christopher Rohde ◽  
...  
Keyword(s):  
Learning Disabilities ◽  
Antiepileptic Drug ◽  
Antiepileptic Drugs ◽  
Developmental Disorders ◽  
Compulsory Education ◽  
In Utero ◽  
Autism Spectrum ◽  
First Year ◽  
In Utero Exposure ◽  
Adjusted Risk

ObjectivesIn utero exposure to antiepileptic drugs has previously been associated with adverse outcome among offspring, but evidence on longer term milestone development remains limited. We investigated the association between in utero exposure to antiepileptic drugs and learning disabilities in the first year of compulsory education among offspring and assessed which antiepileptic drugs carried the highest risk.MethodsThis population-based case–cohort study used Danish nationwide register data from 2005 to 2008. Cases were offspring exposed to antiepileptic drugs in utero, and controls were unexposed offspring of mothers previously redeeming antiepileptic drug prescriptions. Offspring were followed from birth until the first year of compulsory education from 2011 to 2015. Learning disabilities were defined as mental retardation, specific developmental disorders, autism spectrum disorders, emotional/behavioural disorders or having special educational needs. Logistic regression was used to compute ORs with 95% CIs adjusted for potential confounding.ResultsOf 117 475 incident singleton births, 636 cases and 434 controls were included (median age: 6.1 years, males: 55.7%). Learning disabilities were identified among 7.1% cases compared with 3.7% for controls. During any trimester, the adjusted OR of the association between in utero exposure to antiepileptic drugs and learning disabilities was 2.20 (95% CI 1.16 to 4.17). Among cases not exposed to polytherapy (n=556), in utero exposure to lamotrigine compared with another antiepileptic drug was associated with the lowest adjusted risk (OR 0.42, 95% CI 0.19 to 0.92), and valproate carried a higher risk (OR 4.67, 95% CI 1.73 to 12.59).ConclusionIn utero exposure to antiepileptic drugs was significantly associated with learning disabilities among offspring. Lamotrigine should preferentially be considered over, for example, valproate if clinically feasible.

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