scholarly journals Bisphenol A Exposure in utero Disrupts Hypothalamic Gene Expression Particularly Genes Suspected in Autism Spectrum Disorders and Neuron and Hormone Signaling

2020 ◽  
Vol 21 (9) ◽  
pp. 3129
Author(s):  
Anne D. Henriksen ◽  
Alejandro Andrade ◽  
Erin P. Harris ◽  
Emilie F. Rissman ◽  
Jennifer T. Wolstenholme
Keyword(s):  
Gene Expression ◽  
Autism Spectrum Disorders ◽  
Bisphenol A ◽  
In Utero ◽  
Autism Spectrum ◽  
Differentially Expressed ◽  
Basal Nucleus ◽  
Spectrum Disorders ◽  
And Control ◽  
Upstream Regulators

Bisphenol A (BPA) is an endocrine-disrupting compound detected in the urine of more than 92% of humans, easily crosses the placental barrier, and has been shown to influence gene expression during fetal brain development. The purpose of this study was to investigate the effect of in utero BPA exposure on gene expression in the anterior hypothalamus, the basal nucleus of the stria terminalis (BNST), and hippocampus in C57BL/6 mice. Mice were exposed in utero to human-relevant doses of BPA, and then RNA sequencing was performed on male PND 28 tissue from whole hypothalamus (n = 3/group) that included the medial preoptic area (mPOA) and BNST to determine whether any genes were differentially expressed between BPA-exposed and control mice. A subset of genes was selected for further study using RT-qPCR on adult tissue from hippocampus to determine whether any differentially expressed genes (DEGs) persisted into adulthood. Two different RNA-Seq workflows indicated a total of 259 genes that were differentially expressed between BPA-exposed and control mice. Gene ontology analysis indicated that those DEGs were overrepresented in categories relating to mating, cell–cell signaling, behavior, neurodevelopment, neurogenesis, synapse formation, cognition, learning behaviors, hormone activity, and signaling receptor activity, among others. Ingenuity Pathway Analysis was used to interrogate novel gene networks and upstream regulators, indicating the top five upstream regulators as huntingtin, beta-estradiol, alpha-synuclein, Creb1, and estrogen receptor (ER)-alpha. In addition, 15 DE genes were identified that are suspected in autism spectrum disorders.

AUTISM SPECTRUM DISORDERS FOLLOWING IN UTERO EXPOSURE TO ANTIEPILEPTIC DRUGS

Neurology ◽  
2009 ◽  
Vol 73 (12) ◽  
pp. 997-997 ◽  
Author(s):  
M. L. Evatt ◽  
M. R. DeLong ◽  
W. B. Grant ◽  
J. J. Cannell ◽  
V. Tangpricha
Keyword(s):  
Autism Spectrum Disorders ◽  
Antiepileptic Drugs ◽  
In Utero ◽  
Autism Spectrum ◽  
In Utero Exposure ◽  
Spectrum Disorders

scholarly journals Study of the Effect of Bisphenol A on Oxidative Stress in Children with Autism Spectrum Disorders

2017 ◽  
Vol 33 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Fateheya M. Metwally ◽  
Hend Rashad ◽  
Hala M. Zeidan ◽  
Ayman Kilany ◽  
Ehab R. Abdol Raouf
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Bisphenol A ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals AUTISM SPECTRUM DISORDERS FOLLOWING IN UTERO EXPOSURE TO ANTIEPILEPTIC DRUGS

Neurology ◽  
2008 ◽  
Vol 71 (23) ◽  
pp. 1923-1924 ◽  
Author(s):  
R. L. Bromley ◽  
G. Mawer ◽  
J. Clayton-Smith ◽  
G. A. Baker ◽  
Keyword(s):  
Autism Spectrum Disorders ◽  
Antiepileptic Drugs ◽  
In Utero ◽  
Autism Spectrum ◽  
In Utero Exposure ◽  
Spectrum Disorders

scholarly journals Gene expression in blood is associated with risperidone response in children with autism spectrum disorders

2011 ◽  
Vol 12 (5) ◽  
pp. 368-371 ◽  
Author(s):  
L Lit ◽  
F R Sharp ◽  
K Bertoglio ◽  
B Stamova ◽  
B P Ander ◽  
...  
Keyword(s):  
Gene Expression ◽  
Autism Spectrum Disorders ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorders

microRNAs in Autism Spectrum Disorders

2020 ◽  
Vol 25 (41) ◽  
pp. 4368-4378 ◽  
Author(s):  
Mahesh Mundalil Vasu ◽  
Puthiripadath S. Sumitha ◽  
Parakkal Rahna ◽  
Ismail Thanseem ◽  
Ayyappan Anitha
Keyword(s):  
Gene Expression ◽  
Autism Spectrum Disorders ◽  
Current Knowledge ◽  
Autism Spectrum ◽  
Mammalian Brain ◽  
Regulate Gene Expression ◽  
Rna Molecules ◽  
Non Coding Rna ◽  
Spectrum Disorders ◽  
Long Non Coding Rna

Background: Efforts to unravel the extensive impact of the non-coding elements of the human genome on cell homeostasis and pathological processes have gained momentum over the last couple of decades. miRNAs refer to short, often 18-25 nucleotides long, non-coding RNA molecules which can regulate gene expression. Each miRNA can regulate several mRNAs. Methods: This article reviews the literature on the roles of miRNAs in autism. Results: Considering the fact that ~ 1% of the human DNA encodes different families of miRNAs, their overall impact as critical regulators of gene expression in the mammalian brain should be immense. Though the autism spectrum disorders (ASDs) are predominantly genetic in nature and several candidate genes are already identified, the highly heterogeneous and multifactorial nature of the disorder makes it difficult to identify common genetic risk factors. Several studies have suggested that the environmental factors may interact with the genetic factors to increase the risk. miRNAs could possibly be one of those factors which explain this link between genetics and the environment. Conclusion: In the present review, we have summarized our current knowledge on miRNAs and their complex roles in ASD, and also on their therapeutic applications.

scholarly journals No Association between the rs1799836 Polymorphism of the Monoamine Oxidase B Gene and the Risk of Autism Spectrum Disorders in the Kazakhstani Population

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Anastassiya V. Perfilyeva ◽  
Kira B. Bespalova ◽  
Liliya A. Skvortsova ◽  
Assel Surdeanu ◽  
Aleksandr A. Garshin ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Large Scale ◽  
Genetic Factors ◽  
Genetic Variant ◽  
Autism Spectrum ◽  
Healthy Siblings ◽  
Hardy Weinberg Equilibrium ◽  
Spectrum Disorders ◽  
And Control ◽  
Gender Specific

Autism spectrum disorders (ASDs) are heterogeneous diseases that are triggered by a number of environmental and genetic factors. The aim of the current study was to investigate an association of the rs1799836 genetic variant of the neurotransmitter-related gene MAOB with ASDs. In total, 262 patients diagnosed with ASDs and their 126 healthy siblings were included in the present study. All individuals represented a Kazakhstani population. The distributions of the rs1799836 genotype were in accordance with the Hardy-Weinberg equilibrium among both cases and controls. No statistically significant differences were found in the allelic distributions of this polymorphism between ASD and control subjects (A/G: for males OR=1.11, 95% 0.59-2.06, p=0.75; for females OR=1.14, 95% 0.70-1.86, p=0.76). However, the increased score in the overall CARS was significantly associated with the A allele of rs1799836 MAOB for females (OR=2.31, 95% 1.06-5.04, p=0.03). The obtained results suggest that the rs1799836 polymorphism of the MAOB gene may have little contribution to the development of ASDs but may be involved in pathways contributing to ASD symptom severity in females. Further large-scale investigations are required to uncover possible relationships between rs1799836 MAOB and ASD progression in a gender-specific manner and their possible application as a therapeutic target.

In utero Exposure to  -2-Adrenergic Receptor Agonist Drugs and Risk for Autism Spectrum Disorders

PEDIATRICS ◽  
2016 ◽  
Vol 137 (2) ◽  
pp. e20151316-e20151316 ◽  
Author(s):  
N. B. Gidaya ◽  
B. K. Lee ◽  
I. Burstyn ◽  
Y. Michael ◽  
C. J. Newschaffer ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
In Utero ◽  
Autism Spectrum ◽  
In Utero Exposure ◽  
Spectrum Disorders ◽  
Adrenergic Receptor Agonist

scholarly journals Bisphenol A Exposure in Children With Autism Spectrum Disorders

2015 ◽  
Vol 8 (3) ◽  
pp. 272-283 ◽  
Author(s):  
T. Peter Stein ◽  
Margaret D. Schluter ◽  
Robert A. Steer ◽  
Lining Guo ◽  
Xue Ming
Keyword(s):  
Autism Spectrum Disorders ◽  
Bisphenol A ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorders
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