The Effects of Electroacupuncture on the Extracellular Signal-Regulated Kinase 1/2/P2X3 Signal Pathway in the Spinal Cord of Rats with Chronic Constriction Injury

2013 ◽  
Vol 116 (1) ◽  
pp. 239-246 ◽  
Author(s):  
Jianbo Yu ◽  
Cong Zhao ◽  
Xiaoqin Luo
Keyword(s):  
Spinal Cord ◽  
Chronic Constriction Injury ◽  
Signal Pathway ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

Senkyunolide I Relieves Neuropathic Pain Induced by Chronic Constriction Injury by Inhibiting Activation of Microglia

2021 ◽  
Vol 20 (2) ◽  
pp. 253-258
Author(s):  
Xiaomin Huang ◽  
Miao Huo
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Biological Activities ◽  
Bioactive Components ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Induced Apoptosis ◽  
Kinase Pathway ◽  
Senkyunolide I

As an alternative to the use of narcotics, generally refractory to long-term effectiveness, for the management of neuropathic pain, we have explored the utility of senkyunolide I. Senkyunolide I is one of the bioactive components isolated from Ligusticum chuanxiong Hort known to exhibit multiple biological activities. In this study, we report senkyunolide I inhibition of chronic constriction injury induced neuropathic pain. Mechanistically, senkyunolide I inhibited chronic constriction injury induced apoptosis and the activity of microglia via extracellular signal regulated kinase pathway. We therefore suggest that senkyunolide I could serve as a promising drug for the treatment of neuropathic pain.

scholarly journals Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord

2014 ◽  
Vol 7 (1) ◽  
pp. 25 ◽  
Author(s):  
Ling Zhang ◽  
Guan-Yu Jiang ◽  
Ning-Jing Song ◽  
Ying Huang ◽  
Jia-Yin Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Erk Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Itch Sensation
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