200 LMP Knockout Mice Have Reduced Spine Trabecular Bone Density on Micro-Computed Tomography Due to Decreased BMP Responsiveness

Introduction: Periodontitis is an inflamatory process in supporting tissues of the teeth including the gingiva, cementum, periodontal ligament and alveolar bone. Perioditis ntitis begins with migration of junctional ephithelium toward the apical side and form a pocket on gingiva. Aggressive periodontitis is one of the classifications of periodontitis with characteristics of attacking teens to young adults in relatively fast can lead to severe alveolar bone loss and it is not comparable with local factors that there. Trabeculae are part of the alveolar bone covered by compact bone and cortical bone harder . On radiographs, trabeculae only seen as a radiolucent surrounded by a radiopaque. The purpose of this research was to know the description of alveolar trabecular bone in patients with aggressive periodontitis using Cone Beam Computed Tomography imaging. Methods: This study is descriptive on 72 samples of aggressive periodontitis alveolar travecular bon e by CBCT imaging, taken from 6 archival aggressive periodontitis patients as research subjects, obtained from secondary data in the Radiology Department of RSGM FKG UNPAD. Results: The results of this study from the 3D CBCT imaging of alveolar trabecular bone leading to further describe the more posterior a decline in trabecular bone density and decrease in patients with aggressive periodontitis. Conclusion: The 3D CBCT imaging of alveolar trabecular bone leading to further describe the more posterior a decline in trabecular bone density and decrease in patients with aggressive periodontitis.

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Limitations of Peripheral Quantitative Computed Tomography Metaphyseal Bone Density Measurements

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2007-0126 ◽

2007 ◽

Vol 92 (11) ◽

pp. 4248-4253 ◽

Cited By ~ 33

Author(s):

David C. Lee ◽

Vicente Gilsanz ◽

Tishya A. L. Wren

Keyword(s):

Computed Tomography ◽

Bone Density ◽

Trabecular Bone ◽

Cancellous Bone ◽

Quantitative Computed Tomography ◽

Peripheral Quantitative Computed Tomography ◽

Appendicular Skeleton ◽

Trabecular Bone Density ◽

Density Measurements ◽

Single Slice

Abstract Context: Peripheral quantitative computed tomography (pQCT) measurements are frequently obtained to assess cancellous bone density in the appendicular skeleton. Large variations in bone morphology associated with skeletal development may limit the interpretation of pediatric pQCT studies based on a single slice. Objective: The objective of the study was to characterize the variability in trabecular bone density values along the length of the metaphysis. Design: The design was an analysis of pQCT bone density data. Setting: The study was conducted at a hospital radiology department. Patients: The study included 35 children with cerebral palsy aged 6–12 yr. Main Outcome Measure: Variations in cancellous bone density along the length of the proximal tibial metaphysis were measured. Results: The patterns of decay in metaphyseal trabecular bone density were different in all subjects, and the density changed from the physis to the shaft at a rate of 16.8 ± 8.2% per 1 mm (range 8.6–37.9% per 1 mm). The slopes of the density curve drastically changed in some children over a short period of 6 months. Even with a high correlation (r2 = 0.88) between the density of a slice located a fixed distance from the growth plate and the overall mean metaphysis density, the respective changes in density over 6 months were only moderately correlated (r2 = 0.58). Conclusions: These results underscore the difficulty in interpreting metaphyseal pQCT bone density measurements from a single slice and highlight the need for developing pQCT acquisition techniques that provide more representative bone density determinations in the appendicular skeleton of children.

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