Biomolecular switch from oxidative stress in inflammation to tissue morphogenesis in healing: Fenton-type OH* radical reactions and isoguanosine in metalloregulated RNA bioaptamers of S100-proteins

2002 ◽  
Vol 2002 (Fall) ◽  
Author(s):  
Josef H. Wissler ◽  
Enno Logemann
Keyword(s):  
Oxidative Stress ◽  
S100 Proteins ◽  
Radical Reactions ◽  
Oh Radical ◽  
Tissue Morphogenesis

Mechanism of OH radical reactions with thymine and uracil derivatives

1986 ◽  
Vol 108 (19) ◽  
pp. 5968-5972 ◽  
Author(s):  
Slobodan V. Jovanovic ◽  
Michael G. Simic
Keyword(s):  
Radical Reactions ◽  
Oh Radical ◽  
Uracil Derivatives

scholarly journals Chemical insights, explicit chemistry, and yields of secondary organic aerosol from OH radical oxidation of methylglyoxal and glyoxal in the aqueous phase

2013 ◽  
Vol 13 (17) ◽  
pp. 8651-8667 ◽  
Author(s):  
Y. B. Lim ◽  
Y. Tan ◽  
B. J. Turpin
Keyword(s):  
Acetic Acid ◽  
Aqueous Phase ◽  
Secondary Organic Aerosol ◽  
Organic Aerosol ◽  
Water Soluble ◽  
Oxidation Products ◽  
Radical Reactions ◽  
Organic Radical ◽  
Oh Radical ◽  
Radical Oxidation

Abstract. Atmospherically abundant, volatile water-soluble organic compounds formed through gas-phase chemistry (e.g., glyoxal (C2), methylglyoxal (C3), and acetic acid) have great potential to form secondary organic aerosol (SOA) via aqueous chemistry in clouds, fogs, and wet aerosols. This paper (1) provides chemical insights into aqueous-phase OH-radical-initiated reactions leading to SOA formation from methylglyoxal and (2) uses this and a previously published glyoxal mechanism (Lim et al., 2010) to provide SOA yields for use in chemical transport models. Detailed reaction mechanisms including peroxy radical chemistry and a full kinetic model for aqueous photochemistry of acetic acid and methylglyoxal are developed and validated by comparing simulations with the experimental results from previous studies (Tan et al., 2010, 2012). This new methylglyoxal model is then combined with the previous glyoxal model (Lim et al., 2010), and is used to simulate the profiles of products and to estimate SOA yields. At cloud-relevant concentrations (~ 10−6 − ~ 10−3 M; Munger et al., 1995) of glyoxal and methylglyoxal, the major photooxidation products are oxalic acid and pyruvic acid, and simulated SOA yields (by mass) are ~ 120% for glyoxal and ~ 80% for methylglyoxal. During droplet evaporation oligomerization of unreacted methylglyoxal/glyoxal that did not undergo aqueous photooxidation could enhance yields. In wet aerosols, where total dissolved organics are present at much higher concentrations (~ 10 M), the major oxidation products are oligomers formed via organic radical–radical reactions, and simulated SOA yields (by mass) are ~ 90% for both glyoxal and methylglyoxal. Non-radical reactions (e.g., with ammonium) could enhance yields.

Erythrocytes from magnesium-deficient hamsters display an enhanced susceptibility to oxidative stress

1992 ◽  
Vol 262 (6) ◽  
pp. C1371-C1375 ◽  
Author(s):  
A. M. Freedman ◽  
I. T. Mak ◽  
R. E. Stafford ◽  
B. F. Dickens ◽  
M. M. Cassidy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Serum Lipid ◽  
Myocardial Injury ◽  
Magnesium Deficiency ◽  
Oh Radical ◽  
Membrane Phospholipids ◽  
Intracellular Glutathione ◽  
Generating System

Previous studies in our laboratory have indicated a role for free radical participation in magnesium deficiency cardiomyopathy. We have demonstrated the ability of various antioxidant drugs and nutrients to protect against magnesium deficiency-induced myocardial injury. In this study, we have examined erythrocytes from normal and magnesium-deficient animals and compared their susceptibility to an in vitro oxidative stress. Syrian male hamsters were placed on either magnesium-deficient or magnesium-supplemented diets. Animals from each group also received vitamin E in doses of 10 and 25 mg as subcutaneous implants. Erythrocytes obtained after 14 days on the diet were exposed to an exogenous hydroxyl (.OH) radical generating system (dihydroxyfumarate not equal to Fe3+ ADP) at 37 degrees C for 20 min. Erythrocyte crenation was observed and quantified by scanning electron microscopy. Lipid peroxidation, hemolysis (%), and intracellular glutathione levels were determined. In addition, serum lipid changes and membrane phospholipids were characterized. Our data demonstrate that erythrocytes from magnesium-deficient animals are more susceptible to free radical injury, supporting our hypothesis that magnesium deficiency reduces the threshold antioxidant capacity.

Kinetic study of OH radical reactions with chlorobutane isomers at 298K

1998 ◽  
Vol 296 (3-4) ◽  
pp. 350-356 ◽  
Author(s):  
J.C. Loison ◽  
L. Ley ◽  
R. Lesclaux
Keyword(s):  
Kinetic Study ◽  
Radical Reactions ◽  
Oh Radical

OH radical reactions with ethanolamines: formation of reducing as well as oxidizing radicals

2004 ◽  
Vol 30 (9) ◽  
pp. 837-845 ◽  
Author(s):  
Kamal Kishore ◽  
G R Dey ◽  
T Mukherjee
Keyword(s):  
Radical Reactions ◽  
Oh Radical

Rates of OH radical reactions. III. The reaction OH+C2H4+M at 296 °K

1977 ◽  
Vol 67 (2) ◽  
pp. 674-679 ◽  
Author(s):  
Ralph Overend ◽  
George Paraskevopoulos
Keyword(s):  
Radical Reactions ◽  
Oh Radical

Free radical reactions in socially significant infectious diseases: HIV infection, hepatitis, tuberculosis

2020 ◽  
Vol 75 (3) ◽  
pp. 196-203
Author(s):  
Marina A. Darenskaya ◽  
Lubov I. Kolesnikova ◽  
Sergey I. Kolesnikov
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Infectious Diseases ◽  
Hiv Infection ◽  
Reproductive Age ◽  
Radical Reactions ◽  
Reactive Oxygen Metabolites ◽  
Free Radical Reactions ◽  
Wide Range ◽  
Oxygen Metabolites

The analysis of current literature data on the study of the features of the course of free-radical reactions, as well as the state of the antioxidant defense system at socially significant infectious diseases HIV infection, hepatitis, tuberculosis was carried out. The role of this kind of reaction in the genesis and progression of socially significant infections a long time has been studied. Foreign studies of recent years have been focused on the identification of specific markers of oxidative and carbonyl stress, which make it possible to identify the redox imbalance of the cell under conditions of infection and target affect it to modulate the activity of the main transcription factors of viral proteins and the bacteria pathogenicity. Numerous sources indicate the involvement of active oxygen metabolites in a wide range of events in infected cells and tissues, including neoplastic transformation processes. These biochemical markers can be used as additional criteria for monitoring the progression of infection. At the same time, noticeable gaps in this area there are that may become the goal of future research. The issues of changing free radical reactions depending on gender, age, place of residence of patients remain practically unstudied. There is little data about intensity of oxidative stress in patients of reproductive age with HIV, hepatitis B and C, and pulmonary tuberculosis, as well as the relationship of antioxidant deficiency with reproductive disorders in conditions of infection. These data could serve as the basis for the development of pathogenetically substantiated methods for the correction of socially significant infectious diseases. Modulation of the production of reactive oxygen metabolites and oxidative stress is a potentially new pharmacological approach to reduce the effects of viral and bacterial exposure.

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