scholarly journals Notum coordinates synapse development via extracellular regulation of Wingless trans-synaptic signaling

Development ◽  
2017 ◽  
Vol 144 (19) ◽  
pp. 3499-3510 ◽  
Author(s):  
Danielle L. Kopke ◽  
Sofia C. Lima ◽  
Cyrille Alexandre ◽  
Kendal Broadie
Keyword(s):  
Synapse Development ◽  
Synaptic Signaling

scholarly journals LRRTMs and Neuroligins Bind Neurexins with a Differential Code to Cooperate in Glutamate Synapse Development

2010 ◽  
Vol 30 (22) ◽  
pp. 7495-7506 ◽  
Author(s):  
T. J. Siddiqui ◽  
R. Pancaroglu ◽  
Y. Kang ◽  
A. Rooyakkers ◽  
A. M. Craig
Keyword(s):  
Synapse Development ◽  
Glutamate Synapse

scholarly journals Targeting of NF-κB to Dendritic Spines Is Required for Synaptic Signaling and Spine Development

2018 ◽  
Vol 38 (17) ◽  
pp. 4093-4103 ◽  
Author(s):  
Erica C. Dresselhaus ◽  
Matthew C.H. Boersma ◽  
Mollie K. Meffert
Keyword(s):  
Dendritic Spines ◽  
Synaptic Signaling ◽  
Spine Development

176 A PREFORMED COMPLEX OF POSTSYNAPTIC PROTEINS IS INVOLVED IN EXCITATORY SYNAPSE DEVELOPMENT.

2006 ◽  
Vol 54 (1) ◽  
pp. S110.4-S110
Author(s):  
K. Gerrow ◽  
S. Romorini ◽  
S. M. Nabi ◽  
C. Sala ◽  
A. El-Husseini
Keyword(s):  
Excitatory Synapse ◽  
Synapse Development

Protein synthesis in the neuropil of the rat dentate gyrus during synapse development

1990 ◽  
Vol 26 (4) ◽  
pp. 474-482 ◽  
Author(s):  
L. L. Phillips ◽  
A. E. Pollack ◽  
O. Steward
Keyword(s):  
Protein Synthesis ◽  
Dentate Gyrus ◽  
Synapse Development

scholarly journals Proteomic insights into synaptic signaling in the brain: the past, present and future

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Yalan Xu ◽  
Xiuyue Song ◽  
Dong Wang ◽  
Yin Wang ◽  
Peifeng Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Protein Complexes ◽  
Synaptic Signaling ◽  
Brain Functions ◽  
The Past ◽  
Data Independent Acquisition ◽  
Technological Advances ◽  
Neural Communication ◽  
Chemical Synapses ◽  
The Brain

AbstractChemical synapses in the brain connect neurons to form neural circuits, providing the structural and functional bases for neural communication. Disrupted synaptic signaling is closely related to a variety of neurological and psychiatric disorders. In the past two decades, proteomics has blossomed as a versatile tool in biological and biomedical research, rendering a wealth of information toward decoding the molecular machinery of life. There is enormous interest in employing proteomic approaches for the study of synapses, and substantial progress has been made. Here, we review the findings of proteomic studies of chemical synapses in the brain, with special attention paid to the key players in synaptic signaling, i.e., the synaptic protein complexes and their post-translational modifications. Looking toward the future, we discuss the technological advances in proteomics such as data-independent acquisition mass spectrometry (DIA-MS), cross-linking in combination with mass spectrometry (CXMS), and proximity proteomics, along with their potential to untangle the mystery of how the brain functions at the molecular level. Last but not least, we introduce the newly developed synaptomic methods. These methods and their successful applications marked the beginnings of the synaptomics era.

scholarly journals SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function

Cell Reports ◽  
2018 ◽  
Vol 22 (9) ◽  
pp. 2246-2253 ◽  
Author(s):  
Lucas Matt ◽  
Lyndsey M. Kirk ◽  
George Chenaux ◽  
David J. Speca ◽  
Kyle R. Puhger ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Excitatory Synapse ◽  
Synapse Development

scholarly journals The Effects of Hypoxia and Inflammation on Synaptic Signaling in the CNS

2016 ◽  
Vol 6 (1) ◽  
pp. 6 ◽  
Author(s):  
Gatambwa Mukandala ◽  
Ronan Tynan ◽  
Sinead Lanigan ◽  
John O’Connor
Keyword(s):  
Synaptic Signaling
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