The Effect of Cortisone on Cell Proliferation and Migration in Peripheral Nerves undergoing Wallerian degeneration

Development ◽  
1954 ◽  
Vol 2 (2) ◽  
pp. 114-121
Author(s):  
G. A. Thomas
Keyword(s):  
Cell Proliferation ◽  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Wallerian Degeneration ◽  
Marked Effect ◽  
Cell Proliferation And Migration ◽  
Different Types ◽  
And Migration ◽  
Total Cellularity ◽  
Proliferation And Migration

The effect of cortisone on the proliferation of tissues other than mesenchymal has received little attention. Bullough (1952) showed that cortisone had a marked effect on the mitotic activity of the epidermis in mice, and Leroy (1952) showed a similar effect on immature testes of rats, but no effect on mature ones. McColl & Weston (1953) have studied the influence of cortisone on the process of Wallerian degeneration in peripheral nerve and noted that there was less total cellularity in degenerated nerves from cortisone-treated animals. It was thought useful to undertake a quantitative study of proliferation during Wallerian degeneration in peripheral nerves from cortisone-treated animals because the normal changes in nuclear population during this process have been intensively investigated (Abercrombie & Johnson, 1946; Thomas, 1948), and it is known that different types of cells multiply at different rates.

Hyaluronic Acid Hydrogel Particles Obtained Using Liposomes as Templates

2021 ◽  
Vol 7 (1) ◽  
pp. 7
Author(s):  
Irene Abelenda Núñez ◽  
Ramón G. Rubio ◽  
Francisco Ortega ◽  
Eduardo Guzmán
Keyword(s):  
Cell Proliferation ◽  
Cross Linking ◽  
Hydrogel Particles ◽  
Cell Proliferation And Migration ◽  
Different Types ◽  
And Migration ◽  
Tissue Matrix ◽  
Hyaluronic Acid Hydrogel ◽  
3D Networks ◽  
Proliferation And Migration

Hydrogels (HG) are 3D networks of hydrophilic macromolecules linked by different “cross-linking points”, which have as a main advantage their capacity for the adsorption of large amounts of water without any apparent dissolution. This allows hydrogels to undergo reversible swelling–shrinking processes upon the modification of the environmental conditions (pH, ionic strength or temperature). This stimuli-responsiveness and their ability for entrapping in their interior different types of molecules makes hydrogels suitable platforms for drug delivery applications. Furthermore, HGs exhibit certain similarities to the extracellular tissue matrix and can be used as a support for cell proliferation and migration.

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