scholarly journals Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8

2012 ◽  
Vol 126 (2) ◽  
pp. 613-624 ◽  
Author(s):  
G. Auciello ◽  
D. L. Cunningham ◽  
T. Tatar ◽  
J. K. Heath ◽  
J. Z. Rappoport
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Receptor Signalling

Fibroblast growth factor receptor‐1 interacts with the T‐cell receptor signalling pathway

2003 ◽  
Vol 81 (6) ◽  
pp. 440-450 ◽  
Author(s):  
Victor M Byrd ◽  
Dawn M Kilkenny ◽  
Michael M Dikov ◽  
Martha B Reich ◽  
Jonathan V Rocheleau ◽  
...  
Keyword(s):  
T Cell ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
T Cell Receptor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Cell Receptor ◽  
Signalling Pathway ◽  
Fibroblast Growth ◽  
Receptor Signalling

scholarly journals Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration

Oncogene ◽  
2003 ◽  
Vol 22 (28) ◽  
pp. 4380-4388 ◽  
Author(s):  
Heike Steiling ◽  
Torsten Wüstefeld ◽  
Philippe Bugnon ◽  
Maria Brauchle ◽  
Reinhard Fässler ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Receptor Signalling

The ins and outs of fibroblast growth factor receptor signalling

2014 ◽  
Vol 127 (4) ◽  
pp. 217-231 ◽  
Author(s):  
Stacey J. Coleman ◽  
Charo Bruce ◽  
Athina-Myrto Chioni ◽  
Hemant M. Kocher ◽  
Richard P. Grose
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Cancer Progression ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Major Focus ◽  
Receptor Signalling ◽  
Area Of Interest ◽  
Wide Range

FGFR (fibroblast growth factor receptor) signalling plays critical roles in embryogensis, adult physiology, tissue repair and many pathologies. Of particular interest over recent years, it has been implicated in a wide range of cancers, and concerted efforts are underway to target different aspects of FGFR signalling networks. A major focus has been identifying the canonical downstream signalling pathways in cancer cells, and these are now relatively well understood. In the present review, we focus on two distinct but emerging hot topics in FGF biology: its role in stromal cross-talk during cancer progression and the potential roles of FGFR signalling in the nucleus. These neglected areas are proving to be of great interest clinically and are intimately linked, at least in pancreatic cancer. The importance of the stroma in cancer is well accepted, both as a conduit/barrier for treatment and as a target in its own right. Nuclear receptors are less acknowledged as targets, largely due to historical scepticism as to their existence or importance. However, increasing evidence from across the receptor tyrosine kinase field is now strong enough to make the study of nuclear growth factor receptors a major area of interest.

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