Immunohistochemical Expression of p16INK4A, Ki-67, and Mcm2 Proteins in Gastrointestinal Stromal Tumors: Prognostic Implications and Correlations with Risk Stratification of NIH Consensus Criteria

2006 ◽  
Vol 13 (12) ◽  
pp. 1633-1644 ◽  
Author(s):  
Hsuan-Ying Huang ◽  
Wen-Wei Huang ◽  
Ching-Nan Lin ◽  
Hock-Liew Eng ◽  
Shau-Hsuan Li ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Gastrointestinal Stromal Tumors ◽  
Immunohistochemical Expression ◽  
Ki 67 ◽  
Stromal Tumors ◽  
Prognostic Implications ◽  
Nih Consensus Criteria

scholarly journals Ki-67 expression score correlates to survival rate in gastrointestinal stromal tumors (GIST)

2012 ◽  
Vol 27 (5) ◽  
pp. 315-321 ◽  
Author(s):  
Ricardo Artigiani Neto ◽  
Angela Flavia Logullo ◽  
João Norberto Stávale ◽  
Laércio Gomes Lourenço
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Prognostic Value ◽  
Histological Grade ◽  
Preoperative Evaluation ◽  
S100 Protein ◽  
Clinical Staging ◽  
Immunohistochemical Expression ◽  
Ki 67 ◽  
Stromal Tumors ◽  
Carcinogenic Process

PURPOSE: To evaluate the immunohistochemical expression of p16, Ki-67, p53 and Bcl-2 proteins in gastrointestinal stromal tumors (GIST); to assess the possible association between these variables and clinical and histopathological factors of cancer; and to check for prognostic value of these variables (survival and recurrence). METHODS: A sample of 55 patients treated surgically for GIST in three hospitals was studied. The surgically excised tumors were confirmed as GIST by KIT, vimentin, desmin S100 protein, CD117, 1A4 and CD34 assessment in paraffin blocks. RESULTS: Only 9 (16%) cases of GIST were positive for p53, p16 was positive among 43.6%; 80% of GISTs showed staining for Bcl-2. The proliferative index (expressed as the proportion of positive cells) assessed by immunohistochemical expression of Ki-67 was high in 49% of cases. Elevated Ki-67 scores were associated to high histological grade (p=0.0026) and mitosis index, MI (p=0.0001). High Ki-67 index was associated to death. Expression of p53, p16 and Bcl-2 did not correlate to morphological or clinical variables. CONCLUSIONS: Ki-67 immunohistochemical evaluation should be included in preoperative evaluation of GIST biopsies or surgical specimens as a prognostic tool for clinical staging; and all other proteins studied (Bcl-2, p53 and p16) did not play a role in GIST metabolic or carcinogenic process, remaining without prognostic value.

scholarly journals Interobserver Variability of Mitotic Index and Utility of PHH3 for Risk Stratification in Gastrointestinal Stromal Tumors

2015 ◽  
Vol 143 (3) ◽  
pp. 385-392 ◽  
Author(s):  
Ahmad Alkhasawneh ◽  
John D. Reith ◽  
Tania Zuluaga Toro ◽  
Ayed O. Ayed ◽  
Xiaomin Lu ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Mitotic Index ◽  
Gastrointestinal Stromal Tumors ◽  
Interobserver Variability ◽  
Stromal Tumors

Gastrointestinal Stromal Tumors: A “Benign” Tumor with Hepatic Metastasis after 11 Years

1998 ◽  
Vol 84 (1) ◽  
pp. 78-81 ◽  
Author(s):  
Carlo Ballarini ◽  
Mattia Intra ◽  
Andrea Pisani Ceretti ◽  
Francesco Prestipino ◽  
Filippo Maria Bianchi ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Hepatic Metastasis ◽  
Tumor Size ◽  
Gastrointestinal Stromal Tumors ◽  
Cellular Proliferation ◽  
Malignant Potential ◽  
Mitotic Count ◽  
Proliferation Index ◽  
Ki 67 ◽  
Stromal Tumors

Gastrointestinal stromal tumors (GIST) constitue the largest category of primary non-epithelial neoplasms of the stomach and small bowel. They are characterized by a remarkable cellular variability and their malignant potential is sometimes difficult to predict. Very recent studies, using mitotic count and tumor size as the best determinants of biological behavior, divide GISTs into three groups: benign, borderline and malignant tumors. We report on a male patient who underwent a right hepatectomy for a large metastasis 11 years after the surgical treatment of an antral-pyloric gastric neoplasm, histologically defined as leiomyoblastoma and with clinical, morphological and immunohistochemical features of benignity (low mitotic count, tumor size < 5 cm, low cellular proliferation index). Histological and immunohistochemical analysis of the hepatic metastasis showed the cellular proliferation index (Ki-67) to be positive in 25% of neoplastic cells, as opposed to the primary gastric tumor in which Ki-67 was positive in only 5% of neoplastic cells. In conclusion, although modern immunohistochemical techniques are now available to obtain useful prognostic information, the malignant potential of GISTs is sometimes difficult to predict: neoplasms clinically and histologically defined as benign could metastasize a long time after oncologically correct surgical treatment. Therefore, benign GISTs also require consistent, long-term follow-up.

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