scholarly journals Postoperative CEA and Other Non-traditional Risk Factors for Colon Cancer Recurrence: Findings from Swedish Population-Based Data

2019 ◽  
Vol 27 (4) ◽  
pp. 971-972
Author(s):  
Mary R. Kwaan
Keyword(s):  
Risk Factors ◽  
Colon Cancer ◽  
Cancer Recurrence ◽  
Population Based ◽  
Swedish Population ◽  
Traditional Risk Factors ◽  
Colon Cancer Recurrence

scholarly journals Accurate population-based model for individual prediction of colon cancer recurrence

2021 ◽  
pp. 1-9
Author(s):  
E. Osterman ◽  
J. Ekström ◽  
T. Sjöblom ◽  
H. Kørner ◽  
T. Å. Myklebust ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Recurrence ◽  
Population Based ◽  
Colon Cancer Recurrence

scholarly journals Beyond the NCCN Risk Factors in Colon Cancer: An Evaluation in a Swedish Population-Based Cohort

2020 ◽  
Vol 27 (4) ◽  
pp. 1036-1045 ◽  
Author(s):  
Erik Osterman ◽  
Artur Mezheyeuski ◽  
Tobias Sjöblom ◽  
Bengt Glimelius
Keyword(s):  
Risk Factors ◽  
Colon Cancer ◽  
Recurrence Risk ◽  
Population Based ◽  
Clinicopathological Parameters ◽  
Swedish Population ◽  
Quality Registry ◽  
Additional Information ◽  
Time To Recurrence ◽  
National Quality

Abstract Background The purpose of this study was to investigate whether pT3–4 and pN-subclassifications, lymph-node ratio (LNR), tumour deposits, pre- and postoperative carcinoembryonic antigen (CEA), and C-reactive protein (CRP)—all parameters commonly collected in clinical management—add information about recurrence risk against a background of routine clinicopathological parameters as defined by the NCCN. Methods The prospective cohort consisted of all 416 patients diagnosed with colon cancer stage I–III in Uppsala County between 2010 and 2015. Cox proportional hazard models were used to calculate hazard ratios for time to recurrence and overall survival. The results were compared with the entire Swedish population concerning parameters recorded in the national quality registry, SCRCR, during the same time period. Results The Uppsala cohort was representative of the entire Swedish cohort. In unadjusted analyses, pT3-subclassification, pN-subclassification, LNR, tumour deposits, elevated postoperative CEA, and preoperative CRP correlated with recurrence. After adjusting for T-, N-stage, and NCCN risk factors, pN-subclassification, sidedness, and elevated postoperative CEA levels correlated with recurrence. Survival correlated with parameters associated with recurrence, LNR, and elevated postoperative CRP. Conclusions Additional information on recurrence risk is available from several routinely recorded parameters, but most of the risk is predicted by the commonly used clinicopathological parameters.

scholarly journals A CASE OF ASCENDING COLON CANCER RECURRENCE WITH INTRALUMINAL URETERAL DISSEMINATION MIMICKING PRIMARY URETERAL CANCER, DETECTED DURING INVESTIGATION FOR FEVER

2015 ◽  
Vol 106 (4) ◽  
pp. 264-268
Author(s):  
Ryuichi Nishiyama ◽  
Masashi Kubota ◽  
Toru Kanno ◽  
Takashi Okada ◽  
Yoshihito Higashi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Recurrence ◽  
Ascending Colon ◽  
Ascending Colon Cancer ◽  
Colon Cancer Recurrence

scholarly journals TWO CASES OF COLON CANCER RECURRENCE AT THE HAND-SEWN ANASTOMOSIS SITE AFTER COLECTOMY

2011 ◽  
Vol 72 (3) ◽  
pp. 732-736
Author(s):  
Chihiro NAKAHARA ◽  
Kumi SUYAMA ◽  
Toshimitsu IWASHITA ◽  
Satoshi TOYOSHIMA
Keyword(s):  
Colon Cancer ◽  
Cancer Recurrence ◽  
Anastomosis Site ◽  
Colon Cancer Recurrence

scholarly journals Association of Established Blood Pressure Loci With 10‐Year Change in Blood Pressure and Their Ability to Predict Incident Hypertension

2020 ◽  
Vol 9 (16) ◽  
Author(s):  
Alaitz Poveda ◽  
Naeimeh Atabaki‐Pasdar ◽  
Shafqat Ahmad ◽  
Göran Hallmans ◽  
Frida Renström ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Genetic Variants ◽  
Association Studies ◽  
Risk Scores ◽  
Genome Wide Association Studies ◽  
Swedish Population ◽  
Long Term Changes ◽  
Traditional Risk Factors

Background Genome‐wide association studies have identified >1000 genetic variants cross‐sectionally associated with blood pressure variation and prevalent hypertension. These discoveries might aid the early identification of subpopulations at risk of developing hypertension or provide targets for drug development, amongst other applications. The aim of the present study was to analyze the association of blood pressure‐associated variants with long‐term changes (10 years) in blood pressure and also to assess their ability to predict hypertension incidence compared with traditional risk variables in a Swedish population. Methods and Results We constructed 6 genetic risk scores (GRSs) by summing the dosage of the effect allele at each locus of genetic variants previously associated with blood pressure traits (systolic blood pressure GRS (GRS SBP ): 554 variants; diastolic blood pressure GRS (GRS DBP ): 481 variants; mean arterial pressure GRS (GRS MAP ): 20 variants; pulse pressure GRS (GRS PP ): 478 variants; hypertension GRS (GRS HTN ): 22 variants; combined GRS (GRS com b ): 1152 variants). Each GRS was longitudinally associated with its corresponding blood pressure trait, with estimated effects per GRS SD unit of 0.50 to 1.21 mm Hg for quantitative traits and odds ratios (ORs) of 1.10 to 1.35 for hypertension incidence traits. The GRS comb was also significantly associated with hypertension incidence defined according to European guidelines (OR, 1.22 per SD; 95% CI, 1.10‒1.35) but not US guidelines (OR, 1.11 per SD; 95% CI, 0.99‒1.25) while controlling for traditional risk factors. The addition of GRS comb to a model containing traditional risk factors only marginally improved discrimination (Δarea under the ROC curve = 0.001–0.002). Conclusions GRSs based on discovered blood pressure‐associated variants are associated with long‐term changes in blood pressure traits and hypertension incidence, but the inclusion of genetic factors in a model composed of conventional hypertension risk factors did not yield a material increase in predictive ability.

Gender differences in cardiovascular risk assessment in elderly adults in Ecuador: evidence from a national survey

2018 ◽  
Vol 67 (4) ◽  
pp. 736-742
Author(s):  
Ivan Sisa
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cardiovascular Risk ◽  
Rural Areas ◽  
Risk Model ◽  
Smoking Status ◽  
Population Based ◽  
Cvd Risk ◽  
Serum Triglycerides ◽  
Traditional Risk Factors

The present study aimed to predict the risk of developing cardiovascular disease (CVD) over a 5-year period and how it might vary by sex in an ethnically diverse population of older adults. We used a novel CVD risk model built and validated in older adults named the Systematic Coronary Risk Evaluation in Older Persons (SCORE OP). A population-based study analyzed a total of 1307 older adults. Analyses were done by various risk categories and sex. Of the study population, 54% were female with a mean age of 75±7.1 years. According to the SCORE OP model, individuals were classified as having low (9.8%), moderate (48.1%), and high or very high risk (42.1%) of CVD-related mortality. Individuals at higher risk of CVD were more likely to be male compared with females, 53.9% vs 31.8%, respectively (p<0.01). Males were more likely to be younger, living in rural areas, had higher levels of schooling, and with the exception of smoking status and serum triglycerides, had lower values of traditional risk factors than females. In addition, males were less likely to require blood pressure-lowering therapy and statin drugs than females. This gender inequality could be driven by sociocultural determinants and a risk factor paradox in which lower levels of the cardiovascular risk factors are associated with an increase rather than a reduction in mortality. These data can be used to tailor primary prevention strategies such as lifestyle counseling and therapeutic measures in order to improve male elderly health, especially in low-resource settings.

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