Sedimentation Volume of Sparingly Soluble Salts. II. Effect of Common Ions on the Sedimentation Volume of Barium Sulfate.

SummaryIn this paper an inhibitor is described that is found in hemophilic plasma and serum different from any till now described inhibitor. The inhibitor only inhibits prothrombin activation in the “intrinsic clotting systems”. This inhibitor is probably not present in normal human plasma or serum. It is destroyed by ether and freeze drying, is labile to acid and storage at room temperature. It is stable upon dialysis and has not been adsorbed on barium sulfate, aluminum hydroxide or kaolin. It precipitates at 50% v/v saturation with alcohol. The nature of this inhibitor seems to be a protein or lipoprotein.Factor VIII was isolated from hemophilic plasma. The amount isolated was the same as from normal plasma and the activity properties were not different. Hemophiliacs have normal amounts of factor VIII.

Download Full-text

“In vitro” Neutralization with Oxalate Ion of the Anticoagulant Effect of Heparin

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654928 ◽

1961 ◽

Vol 05 (02) ◽

pp. 314-318 ◽

Cited By ~ 1

Author(s):

W. O Cruz ◽

L Meis ◽

C. P Dietrich

Keyword(s):

Calcium Oxalate ◽

Aluminium Hydroxide ◽

Barium Sulfate ◽

Anticoagulant Effect ◽

Normal Plasma ◽

Oxalate Ion

SummaryHeparinized blood or plasma coagulates if, after addition of oxalate, recalcification follows. Of the decalcifying agents only oxalate ion has been suitable for demonstrating this phenomenon. Oxalate seem to accomplish two different roles connected with this effect: a fundamental one, i. e., to sensitize a heparinlipoprotein complex to the action of an anti-heparin factor found in normal plasma or serum and a secondary one, related to its capacity to adsorb this antiheparin factor. The latter is removable by centrifugation. This anti-heparin oxalate factor, which is able to counteract the action of heparin after previous addition of oxalate, was found in sequestrened, Dowex 50 resin plasma or in serum, but is not active in citrated plasma. This factor was removed from plasma by adsorption with barium sulfate, aluminium hydroxide or calcium oxalate and was eluted from these adsorbants after incubation with saline.

Download Full-text

A Simple Method for Preparing Fibrinogen

Thrombosis and Haemostasis ◽

10.1055/s-0038-1655637 ◽

1966 ◽

Vol 16 (01/02) ◽

pp. 198-206 ◽

Cited By ~ 26

Author(s):

W Straughn ◽

R. H Wagner

Keyword(s):

Barium Sulfate ◽

Caproic Acid ◽

Aminobutyric Acid ◽

Gamma Aminobutyric Acid ◽

Human Fibrinogen ◽

Simple Method ◽

High Yields ◽

Marked Stability

SummaryA simple new procedure is reported for the isolation of canine, bovine, porcine, and human fibrinogen. Two molar β-alanine is used to precipitate fibrinogen from barium sulfate adsorbed plasma. The procedure is characterized by dependability and high yields. The material is 95% to 98% clottable protein but still contains impurities such as plasminogen and fibrin-stabilizing factor. Plasminogen may be removed by adsorption with charcoal. The fibrinogen preparations exhibit marked stability to freezing, lyophilization, and dialysis. Epsilon-amino-n-caproic acid and gamma-aminobutyric acid which were also studied have the property of precipitating proteins from plasma but lack the specificity for fibrinogen found with β-alanine.

Download Full-text

Potential anticonvulsants: Substituted N-benzylidene derivatives of 10-(4-aminopiperazino)-10,11-dihydrodibenzo[b,f]thiepins

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19831173 ◽

1983 ◽

Vol 48 (4) ◽

pp. 1173-1186 ◽

Cited By ~ 2

Author(s):

Václav Bártl ◽

Jiří Holubek ◽

Emil Svátek ◽

Marie Bartošová ◽

Miroslav Protiva

Keyword(s):

Acute Toxicity ◽

Water Soluble ◽

Hypotensive Activity ◽

Anticonvulsant Effect ◽

Maximal Electroshock ◽

Soluble Salts ◽

Sleeping Time ◽

Central Depression ◽

Derivatives Of ◽

Electroshock Seizures

Reactions of 10-(4-aminopiperazino)-10,11-dihydrodibenzo[b,f]thiepins XIVa-XIVd with benzaldehyde, 3,4-dimethoxybenzaldehyde, 4-dimethylaminobenzaldehyde, salicylaldehyde, 3-ethoxy-4-hydroxybenzaldehyde, 2-(2-dimethylaminoethoxy)benzaldehyde, 3-(2-dimethylaminoethoxy)benzaldehyde and 3-ethoxy-4-(2-dimethylaminoethoxy)benzaldehyde afforded a series of 19 hydrazones IIIa-Xc. Some of them showed the expected anticonvulsant effect but only towards pentetrazole; antagonism of maximal electroshock seizures was not observed. In general, the products have a character of tranquillizers: in higher does they produce central depression, potentiate the thiopental sleeping time, have hypothermic action; in single cases antiamphetamine, antireserpine, antihistamine and cataleptic effects were observed. The water-soluble salts of the basic hydrazones VIIIa, VIIIc, IXc and Xc, administered parenterally, showed a rather high acute toxicity and revealed also adrenolytic and hypotensive activity.

Download Full-text

Soluble Salts Quantitative Characterization and Thermodynamic Modeling on Roman Bricks to Assess the Origin of Their Formation

Molecules ◽

10.3390/molecules26102866 ◽

2021 ◽

Vol 26 (10) ◽

pp. 2866

Author(s):

Claudia Scatigno ◽

Nagore Prieto-Taboada ◽

Giulia Festa ◽

Juan Manuel Madariaga

Keyword(s):

Archaeological Site ◽

Risk Level ◽

Salt Weathering ◽

Soluble Salts ◽

High Concentration ◽

Quantitative Characterization ◽

Chromatography Analysis ◽

Acidic Gases ◽

Hygroscopic Moisture ◽

Ostia Antica

The environmental weathering and the formation of efflorescences on the brick walls are studied at the “Casa di Diana” Mithraeum at Ostia Antica archaeological site. Previous studies on subsoil, bedrock, hydrological systems and environmental conditions, and new ion chromatography analysis combined with ECOS-RUNSALT and Medusa-Hydra thermodynamic modelling software, had allowed us to identify the subsoil contamination related to soluble salts. The atmospheric acidic gases, CO2 and SO2, are determined as the main salt weathering species. A dry deposition after a subsequent hydration action from the shallow freshwater aquifer that reaches up to 1 m on the walls is identified as the mechanism of salt formation. An evaluation of potential sources such as the nearby Fiumicino airport, CO2-rich gases inputs from fumaroles and CO2 inputs was also debated. The risk level of contamination the surfaces of the materials should be considered mildly/very polluted with a medium/high risk of hygroscopic moisture due to the high concentration of sulphates.

Download Full-text