scholarly journals Interleukin 2 promotes expression of an interleukin 2 receptor and proliferation of T cells stimulated with non-mitogenic dose of concanavalin A.

1989 ◽  
Vol 14 (2) ◽  
pp. 193-197
Author(s):  
Hiroshi Komada ◽  
Hiroshi Nakabayashi ◽  
Mari Hara ◽  
Masayuki Hara ◽  
Takao Takahashi ◽  
...  
Keyword(s):  
T Cells ◽  
Concanavalin A ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor

Diltiazem inhibits transferrin receptor expression and causes G1 arrest in normal and neoplastic T cells

1986 ◽  
Vol 6 (12) ◽  
pp. 4244-4250
Author(s):  
L M Neckers ◽  
S Bauer ◽  
R C McGlennen ◽  
J B Trepel ◽  
K Rao ◽  
...  
Keyword(s):  
T Cells ◽  
Transferrin Receptor ◽  
Interleukin 2 ◽  
Receptor Expression ◽  
Calcium Flux ◽  
G1 Arrest ◽  
Receptor Mrna ◽  
Interleukin 2 Receptor ◽  
Transferrin Receptor Expression ◽  
Malignant T Cells

Transferrin receptor expression is essential for the proliferation of both normal and malignant T cells. While transferrin receptor expression in normal T cells is tightly coupled to interleukin-2 receptor expression, transferrin receptor expression in malignant cells is usually constitutive and is released from this constraint. Temporally, the appearance of these membrane receptors is preceded by changes in the expression of the proto-oncogenes c-myc and c-myb. In addition, although an increase in the level of intracellular free calcium occurs early in the sequence of T-cell activation, the activation events dependent on this calcium flux have not been resolved. In the present study we report that diltiazem, an ion channel-blocking agent that inhibits calcium influx, arrested the growth in vitro of both normal and malignant human T cells in the G1 phase of the cell cycle. However, diltiazem did not inhibit the expression of c-myc or interleukin-2 receptor mRNA and protein in normal mitogen-activated T cells or the constitutive expression of c-myc and c-myb mRNA in malignant T cells (T acute lymphoblastic leukemia cells). In contrast, diltiazem prevented the induction of transferrin receptor (mRNA and protein) in normal T cells and caused a progressive loss of transferrin receptor (mRNA and protein) in malignant T cells. These data demonstrate that diltiazem can dissociate several growth-related processes normally occurring in G1 and thereby disrupt the biochemical cascade leading to cell proliferation.

scholarly journals Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.

1988 ◽  
Vol 167 (2) ◽  
pp. 612-622 ◽  
Author(s):  
P Bacha ◽  
D P Williams ◽  
C Waters ◽  
J M Williams ◽  
J R Murphy ◽  
...  
Keyword(s):  
T Cells ◽  
Protein Synthesis ◽  
T Cell ◽  
Diphtheria Toxin ◽  
Interleukin 2 ◽  
Elongation Factor ◽  
High Affinity ◽  
Interleukin 2 Receptor ◽  
Human T Cell ◽  
Inhibition Of Protein Synthesis

The IL-2 toxin-mediated inhibition of protein synthesis in high affinity IL-2-R-positive murine and human T cell lines has been examined. Both excess free IL-2 and mAb to the Tac epitope of the p55 subunit of IL-2-R are shown to block the action of IL-2 toxin; whereas, agents that interact with other receptors or antigens on the T cell surface have no effect. We show that IL-2 toxin, like diphtheria toxin, must pass through an acidic vesicle in order to intoxicate target T cells. Finally, we demonstrate that the IL-2 toxin-mediated inhibition of protein synthesis in both human and murine T cells that bear the high affinity IL-2-R is due to the classic diphtheria toxin fragment A-catalyzed ADP ribosylation of elongation factor 2.

Inhibition of Interleukin-2 Synthesis and Interleukin-2 Receptor α Expression on T Cells by a Cell-Free Factor Derived from a CD4+ Regulatory T Cell Clone

1993 ◽  
Vol 68 (3) ◽  
pp. 256-262 ◽  
Author(s):  
Takashi Okino ◽  
Nitya G. Chakraborty ◽  
Paul Stabach ◽  
Daniel R. Twardzik ◽  
Steven J. Padula ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Clone ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor ◽  
T Cell Clone ◽  
A Cell

Interleukin-2 Receptor Subunit Expression and Function on Human Peripheral T Cells Is Not Dependent on the Anticoagulant

Blood ◽  
1998 ◽  
Vol 92 (8) ◽  
pp. 2989-2993 ◽  
Author(s):  
Guido L. Vanham ◽  
Godelieve Penne ◽  
Chris Vereecken ◽  
Johan Vingerhoets ◽  
Luc Kestens
Keyword(s):  
T Cells ◽  
Interleukin 2 ◽  
Receptor Subunit ◽  
Interleukin 2 Receptor ◽  
Peripheral T Cells ◽  
Subunit Expression ◽  
And Function

scholarly journals Defective Interferon Gamma Production in Neonatal T Cells Is Independent of Interleukin-2 Receptor Binding

1991 ◽  
Vol 30 (3) ◽  
pp. 270-275 ◽  
Author(s):  
Ursula von Freeden ◽  
Norbert Zessack ◽  
Frans van Valen ◽  
Stefan Burdach
Keyword(s):  
T Cells ◽  
Interferon Gamma ◽  
Receptor Binding ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor

INHIBITION OF INTERLEUKIN 2 RECEPTOR EXPRESSION IN NORMAL HUMAN T CELLS BY CYCLOSPORINE

1992 ◽  
Vol 53 (1) ◽  
pp. 146-150 ◽  
Author(s):  
BAOGUI LI ◽  
PRABODH K. SEHAJPAL ◽  
AJIT SUBRAMANIAM ◽  
ANTONIO JOSEPH ◽  
KURT H. STENZEL ◽  
...  
Keyword(s):  
T Cells ◽  
Interleukin 2 ◽  
Receptor Expression ◽  
Interleukin 2 Receptor ◽  
Human T Cells ◽  
Normal Human

Interleukin-2 Receptor Subunit Expression and Function on Human Peripheral T Cells Is Not Dependent on the Anticoagulant

Blood ◽  
1998 ◽  
Vol 92 (8) ◽  
pp. 2989-2993
Author(s):  
Guido L. Vanham ◽  
Godelieve Penne ◽  
Chris Vereecken ◽  
Johan Vingerhoets ◽  
Luc Kestens
Keyword(s):  
T Cells ◽  
Interleukin 2 ◽  
Receptor Subunit ◽  
Interleukin 2 Receptor ◽  
Peripheral T Cells ◽  
Subunit Expression ◽  
And Function
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