scholarly journals In Vitro Dissolution Tests Corresponding to the in Vivo Dissolution of Clarithromycin Tablets in the Stomach and Intestine.

1995 ◽  
Vol 43 (11) ◽  
pp. 1943-1948 ◽  
Author(s):  
Kuniaki ISHII ◽  
Yoko KATAYAMA ◽  
Shigeru ITAI ◽  
Yuji ITO ◽  
Hidehumi HAYASHI
Keyword(s):  
In Vitro Dissolution ◽  
Dissolution Tests ◽  
In Vivo Dissolution

scholarly journals Development of Level A In Vitro–Vivo Correlation for Electrosprayed Microspheres Containing Leuprolide: Physicochemical, Pharmacokinetic, and Pharmacodynamic Evaluation

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 36
Author(s):  
Dong-Seok Lee ◽  
Dong Wook Kang ◽  
Go-Wun Choi ◽  
Han-Gon Choi ◽  
Hea-Young Cho
Keyword(s):  
Plasma Concentration ◽  
Prediction Error ◽  
Subcutaneous Administration ◽  
In Vitro Dissolution ◽  
Burst Release ◽  
Maximum Plasma ◽  
Time Curve ◽  
In Vivo Dissolution

This study optimized the preparation of electrosprayed microspheres containing leuprolide and developed an in vitro–in vivo correlation (IVIVC) model that enables mutual prediction between in vitro and in vivo dissolution. The pharmacokinetic (PK) and pharmacodynamic (PD) study of leuprolide was carried out in normal rats after subcutaneous administration of electrosprayed microspheres. The parameters of the IVIVC model were estimated by fitting the PK profile of Lucrin depot® to the release compartment of the IVIVC model, thus the in vivo dissolution was predicted from the in vitro dissolution. From this correlation, the PK profile of leuprolide was predicted from the results of in vivo dissolution. The IVIVC model was validated by estimating percent prediction error (%PE) values. Among prepared microspheres, an optimal formulation was selected using the IVIVC model. The maximum plasma concentration and the area under the plasma concentration–time curve from zero to infinity from the predicted PK profile were 4.01 ng/mL and 52.52 h·ng/mL, respectively, and from the observed PK profile were 4.14 ng/mL and 56.95 h·ng/mL, respectively. The percent prediction error values of all parameters did not exceed 15%, thus the IVIVC model satisfies the validation criteria of the Food and Drug Administration (FDA) guidance. The PK/PD evaluation suggests that the efficacy of OL5 is similar to Lucrin depot®, but the formulation was improved by reducing the initial burst release.

Application of In Vitro Dissolution Tests to Different Uranium Compounds and Comparison with In Vivo Data

1998 ◽  
Vol 79 (1) ◽  
pp. 33-37 ◽  
Author(s):  
E. Ansoborlo ◽  
R.A. Guilmette ◽  
M.D. Hoover ◽  
V. Chazel ◽  
P. Houpert ◽  
...  
Keyword(s):  
In Vitro Dissolution ◽  
Uranium Compounds ◽  
Dissolution Tests

In vitro dissolution methodology, mini-Gastrointestinal Simulator (mGIS), predicts better in vivo dissolution of a weak base drug, dasatinib

2015 ◽  
Vol 76 ◽  
pp. 203-212 ◽  
Author(s):  
Yasuhiro Tsume ◽  
Susumu Takeuchi ◽  
Kazuki Matsui ◽  
Gregory E. Amidon ◽  
Gordon L. Amidon
Keyword(s):  
In Vitro Dissolution ◽  
Weak Base ◽  
In Vivo Dissolution

scholarly journals Dissolution Test for Mianserin Hydrochloride in Tablets

2019 ◽  
Vol 3 (2) ◽  
pp. 18-22
Author(s):  
Letícia Lenz Sfair ◽  
Caren Gobetti ◽  
Martin Steppe ◽  
Elfrides Schapoval
Keyword(s):  
Drug Release ◽  
In Vitro Dissolution ◽  
Dissolution Test ◽  
Dissolution Medium ◽  
Drug Release Profile ◽  
Dissolution Tests ◽  
Usp Apparatus ◽  
Usp Apparatus 2

A dissolution test for mianserin hydrochloride in coated tablets containing 30 mg was developed and validated using a fast ultraviolet spectrophotometric method. The appropriate conditions were determinate after testing sink conditions, agitation spped and dissolution medium. The sink conditions tested showed that mianserin hydrochloride was soluble in 0.01 and 0.1 M hydrochloric acid (HCl), acetate buffer pH 4.1 and 5.0 and phosphate buffer pH 6.8. Then, dissolution tests were performed to investigate the drug release in each medium. Optimal conditions to carry out the dissolution test were 900 mL 0.1 M HCl and USP apparatus 2 (paddle) at 50 rpm stirring speed. The quantification method was also adapted and validated. The UV method showed specificity, linearity, precision and accuracy. The in vitro dissolution test can be used to evaluate the drug release profile and the data was used as an aid to establish a possible correlation with in vivo data.

scholarly journals Finding Use for Sorghum Bicolor Leaf Sheath in Coating Technology

2021 ◽  
Author(s):  
Johnson Ajeh Isaac ◽  
Kayode Ilesanmi Fasuba
Keyword(s):  
Sorghum Bicolor ◽  
Aqueous Extract ◽  
Scientific Information ◽  
Leaf Sheath ◽  
In Vitro Dissolution ◽  
Dependent Manner ◽  
Coating Agent ◽  
Dissolution Tests

This study aimed to investigate the potential use of aqueous extract of Sorghum bicolor leaf sheath (SBLS) as a coating agent for paracetamol tablets. The mechanical properties of the coated tablets were assessed using crushing strength and friability test, while the release properties of the tablet were evaluated using disintegration and dissolution tests. The physicochemical properties of the coated tablets did not show any striking differences when compared with the uncoated tablet as par compendium specifications, which formed the basis for performing further in vitro dissolution study. Our data showed that SBLS enhanced the hardness and friability of the tablets in a dose-dependent manner. Tablets coated with 3, 5, and 7.5% of SBLS disintegrated in 8.13, 6.25, and 4.13 minutes, respectively, while the uncoated tablet disintegrated in 0.7 minutes. Furthermore, 3, 5, and 7.5% of SBLS-coated tablets exhibited slower release of their active ingredient (releasing 21, 16, and 17%, respectively) than that of the uncoated tablet (releasing 40%) in 5 minutes. Besides, comparison between the dissolution profiles was successfully achieved using difference factor (f1) and similarity factor (f2). The apparent dissimilarity between our coated tablets and the uncoated one led to further study of convolution in vitro–in vivo correlation, with the aim to obtain data that converted into mathematical prediction of in vivo data. For all batches, the percent predictable errors of C max and T max were within the acceptable limit of no more than 10%. In summary, SBLS aqueous extract is a potential and protective coat agent for paracetamol tablets. The in vitro established dissolution of the coated tablets provided scientific information for the prediction of the in vivo plasma drug profile.

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