Extracellular Matrix Remodeling Following Repeated Bouts of Eccentric Contractions in Human Skeletal Muscle

2015 ◽  
Vol 47 ◽  
pp. 99
Author(s):  
Robert Hyldahl ◽  
Brad Nelson ◽  
Tyson Welling ◽  
Logan Groscost ◽  
Allen Parcell
Keyword(s):  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Human Skeletal Muscle ◽  
Eccentric Contractions ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

scholarly journals The Development of Cancer Cachexia Negatively Impacts Skeletal Muscle Extracellular Matrix Remodeling

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 498
Author(s):  
Wesley Haynie ◽  
Jacob Brown ◽  
David Lee ◽  
Megan Rosa-Caldwell ◽  
Richard Perry ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Cancer Cachexia ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

scholarly journals Weight Gain Reveals Dramatic Increases in Skeletal Muscle Extracellular Matrix Remodeling

2014 ◽  
Vol 99 (5) ◽  
pp. 1749-1757 ◽  
Author(s):  
Charmaine S. Tam ◽  
Jeffrey D. Covington ◽  
Sudip Bajpeyi ◽  
Yourka Tchoukalova ◽  
David Burk ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Weight Gain ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

Skeletal muscle extracellular matrix remodeling after short-term overfeeding in healthy humans

Metabolism ◽  
2017 ◽  
Vol 67 ◽  
pp. 26-30 ◽  
Author(s):  
Charmaine S Tam ◽  
Rima Chaudhuri ◽  
Amy T Hutchison ◽  
Dorit Samocha-Bonet ◽  
Leonie K Heilbronn
Keyword(s):  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Short Term ◽  
Healthy Humans

scholarly journals Insulin Resistance, Skeletal Muscle Extracellular Matrix Remodeling, And The Effect Of Exercise

2020 ◽  
Vol 52 (7S) ◽  
pp. 909-909
Author(s):  
Dongmei Liu ◽  
Carl Bender ◽  
JunJun Lv ◽  
Min Sun ◽  
Paul Gordon
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

scholarly journals The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor Progression

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1046
Author(s):  
Jorge Martinez ◽  
Patricio C. Smith
Keyword(s):  
Extracellular Matrix ◽  
Type I Collagen ◽  
Cell Metabolism ◽  
Breast Tumors ◽  
Extracellular Matrix Remodeling ◽  
Type I ◽  
Matrix Remodeling ◽  
Desmoplastic Reaction ◽  
The Impact

Desmoplastic tumors correspond to a unique tissue structure characterized by the abnormal deposition of extracellular matrix. Breast tumors are a typical example of this type of lesion, a property that allows its palpation and early detection. Fibrillar type I collagen is a major component of tumor desmoplasia and its accumulation is causally linked to tumor cell survival and metastasis. For many years, the desmoplastic phenomenon was considered to be a reaction and response of the host tissue against tumor cells and, accordingly, designated as “desmoplastic reaction”. This notion has been challenged in the last decades when desmoplastic tissue was detected in breast tissue in the absence of tumor. This finding suggests that desmoplasia is a preexisting condition that stimulates the development of a malignant phenotype. With this perspective, in the present review, we analyze the role of extracellular matrix remodeling in the development of the desmoplastic response. Importantly, during the discussion, we also analyze the impact of obesity and cell metabolism as critical drivers of tissue remodeling during the development of desmoplasia. New knowledge derived from the dynamic remodeling of the extracellular matrix may lead to novel targets of interest for early diagnosis or therapy in the context of breast tumors.

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