scholarly journals Tumor Necrosis Factor-α Converting Enzyme Inactivation Ameliorates High-Fat Diet-Induced Insulin Resistance and Altered Energy Homeostasis

2011 ◽  
Vol 75 (10) ◽  
pp. 2482-2490 ◽  
Author(s):  
Hidehiro Kaneko ◽  
Toshihisa Anzai ◽  
Keisuke Horiuchi ◽  
Kokichi Morimoto ◽  
Atsushi Anzai ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Fat Diet ◽  
Tumor Necrosis ◽  
Energy Homeostasis ◽  
Tumor Necrosis Factor Α ◽  
Enzyme Inactivation ◽  
Converting Enzyme ◽  
High Fat ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Blockade of angiotensin-converting enzyme or tumor necrosis factor-α reverses maternal high-fat diet-induced sensitization of angiotensin II hypertension in male rat offspring

2020 ◽  
Vol 318 (2) ◽  
pp. R351-R359 ◽  
Author(s):  
Xue-Fang Wang ◽  
Jian-Dong Li ◽  
Yan-Li Huo ◽  
Yu-Ping Zhang ◽  
Zhi-Qin Fang ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Adult Offspring ◽  
Ang Ii ◽  
Converting Enzyme ◽  
High Fat ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Maternal high-fat diet (HFD) is associated with metabolic syndrome and cardiovascular diseases in adult offspring. Our previous study demonstrated that maternal HFD enhances pressor responses to ANG II or a proinflammatory cytokine (PIC), which is associated with increased expression of brain renin-angiotensin system (RAS) components and PICs in adult offspring. The present study further investigated whether inhibition of angiotensin-converting enzyme (ACE) or tumor necrosis factor-α (TNF-α) blocks sensitization of ANG II hypertension in offspring of HFD dams. All offspring were bred from dams with normal fat diet (NFD) or HFD starting two weeks before mating and maintained until weaning of the offspring. Then the weaned offspring were treated with an ACE inhibitor (captopril) or a TNF-α inhibitor (pentoxifylline) in the drinking water through the end of testing with a slow-pressor dose of ANG II. RT-PCR analyses of the lamina terminalis and paraventricular nucleus revealed upregulation of mRNA expression of several RAS components and PICs in male offspring of HFD dams when compared with age-matched offspring of NFD dams. The enhanced gene expression was attenuated by blockade of either RAS or PICs. Likewise, ANG II administration produced an augmented pressor response in offspring of HFD dams. This was abolished by either ACE or TNF-α inhibitor. Taken together, this study provides mechanistic evidence and a therapeutic strategy that systemic inhibition of the RAS and PICs can block maternal HFD-induced sensitization of ANG II hypertension, which is associated with attenuation of brain RAS and PIC expression in offspring.

scholarly journals Increased tumor necrosis factor α-converting enzyme activity induces insulin resistance and hepatosteatosis in mice

Hepatology ◽  
2009 ◽  
Vol 51 (1) ◽  
pp. 103-110 ◽  
Author(s):  
Loredana Fiorentino ◽  
Alessia Vivanti ◽  
Michele Cavalera ◽  
Valeria Marzano ◽  
Maurizio Ronci ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Enzyme Activity ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Converting Enzyme ◽  
Factor Α ◽  
Necrosis Factor

Tumor Necrosis Factor-α-converting Enzyme (TACE) Levels in Periodontal Diseases

2008 ◽  
Vol 87 (3) ◽  
pp. 273-277 ◽  
Author(s):  
N. Bostanci ◽  
G. Emingil ◽  
B. Afacan ◽  
B. Han ◽  
T. Ilgenli ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Periodontal Diseases ◽  
Immunosuppressive Treatment ◽  
Aggressive Periodontitis ◽  
Converting Enzyme ◽  
Factor Α ◽  
Necrosis Factor ◽  
Healthy Persons

Tumor necrosis factor-α-converting enzyme (TACE) is a metalloprotease which can shed several cytokines from the cell membrane, including receptor activator of NF-κB ligand (RANKL). This study aimed to investigate the hypothesis that TACE would be elevated in the gingival crevicular fluid (GCF) of persons with periodontitis. Total TACE amounts in GCF were higher in persons with chronic and aggressive periodontitis than in those with gingivitis or in healthy persons. TACE concentrations in GCF were higher in persons with chronic and aggressive periodontitis than in those with gingivitis, although not significantly higher than in healthy persons. Persons with chronic periodontitis receiving immunosuppressive treatment exhibited over 10-fold lower TACE levels than the other periodontitis groups. TACE was positively correlated with probing pocket depth, clinical attachment levels, and RANKL concentrations in GCF. In conclusion, the increased GCF TACE levels in persons with periodontitis and their positive correlation with RANKL may indicate an association of this enzyme with alveolar bone loss, and may warrant special attention in future therapeutic approaches.

Discovery of Novel Hydantoins as Selective Non-Hydroxamate Inhibitors of Tumor Necrosis Factor-α Converting Enzyme (TACE).

ChemInform ◽  
2007 ◽  
Vol 38 (29) ◽  
Author(s):  
James E. II Sheppeck ◽  
John L. Gilmore ◽  
Anle Yang ◽  
Xiao-Tao Chen ◽  
Chu-Biao Xue ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Converting Enzyme ◽  
Factor Α ◽  
Necrosis Factor
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