Serum Cystatin C, a Sensitive Marker of Renal Function and Cardiovascular Disease, Decreases After Smoking Cessation

AbstractEarly detection of renal dysfunction is important in burn patients. This study evaluated whether serum cystatin C (CysC) is a potentially accurate and sensitive marker for identification of reduced glomerular filtration rate (GFR) and the risk factors of impaired renal function in major burn patients.A total of 48 adult patients with major burn injury were enrolled. Renal function was assessed using serum creatinine (sCr), 24-h urinary creatinine clearance (24-hCrCl), sCr-based formulae and CysC-based formulae on the second day and seventh day post-burn.There was a high prevalence (27.1%) of acute impaired renal function in major burn patients in the first week post-burn. CysC-based formulae for estimated GFR (eGFR) are more accurate and sensitive for detection of impaired renal function than sCr-based formulae. Multivariate logistic regression analysis demonstrated that age (OR, 2.08; 95% CI 1.26–4.77) and the percentage of burn area (OR, 3.41; 95% CI 1.64–6.95) were independent risk factors of impaired renal function.The results of this study suggest that CysC is a more accurate and sensitive marker for identification of acute impaired renal function in major burn patients than sCr. It is important to measure CysC and calculate eGFR to prevent acute renal failure and modify drug doses in burn patients, especially those of older age and with major burn areas.

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Serum Cystatin C is a Potential Endogenous Marker for the Estimation of Renal Function in Male Gout Patients with Renal Impairment

Journal of Korean Medical Science ◽

10.3346/jkms.2010.25.1.42 ◽

2010 ◽

Vol 25 (1) ◽

pp. 42 ◽

Cited By ~ 7

Author(s):

Jung-Yoon Choe ◽

Sung-Hoon Park ◽

Seong-Kyu Kim

Keyword(s):

Renal Function ◽

Renal Impairment ◽

Cystatin C ◽

Serum Cystatin C ◽

Serum Cystatin

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Population Pharmacokinetic Analysis of Vancomycin Using Serum Cystatin C as a Marker of Renal Function

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00661-09 ◽

2009 ◽

Vol 54 (2) ◽

pp. 778-782 ◽

Cited By ~ 33

Author(s):

Akihiro Tanaka ◽

Tetsuya Aiba ◽

Takashi Otsuka ◽

Katsuya Suemaru ◽

Tatsuya Nishimiya ◽

...

Keyword(s):

Renal Function ◽

Cystatin C ◽

Predictive Performance ◽

Pharmacokinetic Analysis ◽

Pharmacokinetic Parameters ◽

Population Pharmacokinetic ◽

Serum Cystatin C ◽

Serum Cystatin ◽

New Model ◽

The Mean

ABSTRACT We determined the population pharmacokinetics of vancomycin (VAN) using the glomerular filtration rate (GFR) estimated from the serum cystatin C concentration. We examined the predictive performance of the trough serum VAN concentration for determination of the initial dose by using a new model for the analysis of the population pharmacokinetic parameters. Data for 86 patients were used to estimate the values of the population pharmacokinetic parameters. Analysis with a nonlinear mixed-effects modeling program was done by using a one-compartment model. Data for 78 patients were used to evaluate the predictive performance of the new model for the analysis of population pharmacokinetic parameters. The estimated GFR values determined by using Hoek's formula correlated linearly with VAN clearance (VAN clearance [ml/min] = 0.825 × GFR). The mean volume of distribution was 0.864 (liters/kg). The interindividual variability of VAN clearance was 19.8%. The accuracy of the prediction determined by use of the new model was statistically better than that determined by use of the Japanese nomogram-based model because the 95% confidence interval (−3.45 to −1.38) of the difference in each value of the mean absolute error (−2.41) did not include 0. Use of the serum cystatin C concentration as a marker of renal function for prediction of serum VAN concentrations may be useful.

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