Serum cystatin C is an early biomarker for assessment of renal function in burn patients

Author(s):  
Xiaoyan Cai ◽  
Zhaolin Long ◽  
Lianduo Lin ◽  
Yudong Feng ◽  
Naxi Zhou ◽  
...  

AbstractEarly detection of renal dysfunction is important in burn patients. This study evaluated whether serum cystatin C (CysC) is a potentially accurate and sensitive marker for identification of reduced glomerular filtration rate (GFR) and the risk factors of impaired renal function in major burn patients.A total of 48 adult patients with major burn injury were enrolled. Renal function was assessed using serum creatinine (sCr), 24-h urinary creatinine clearance (24-hCrCl), sCr-based formulae and CysC-based formulae on the second day and seventh day post-burn.There was a high prevalence (27.1%) of acute impaired renal function in major burn patients in the first week post-burn. CysC-based formulae for estimated GFR (eGFR) are more accurate and sensitive for detection of impaired renal function than sCr-based formulae. Multivariate logistic regression analysis demonstrated that age (OR, 2.08; 95% CI 1.26–4.77) and the percentage of burn area (OR, 3.41; 95% CI 1.64–6.95) were independent risk factors of impaired renal function.The results of this study suggest that CysC is a more accurate and sensitive marker for identification of acute impaired renal function in major burn patients than sCr. It is important to measure CysC and calculate eGFR to prevent acute renal failure and modify drug doses in burn patients, especially those of older age and with major burn areas.

2019 ◽  
Vol 1 (12) ◽  
pp. 623-627
Author(s):  
Masafumi Funamoto ◽  
Kana Shimizu ◽  
Yoichi Sunagawa ◽  
Yasufumi Katanasaka ◽  
Yusuke Miyazaki ◽  
...  

2009 ◽  
Vol 54 (2) ◽  
pp. 778-782 ◽  
Author(s):  
Akihiro Tanaka ◽  
Tetsuya Aiba ◽  
Takashi Otsuka ◽  
Katsuya Suemaru ◽  
Tatsuya Nishimiya ◽  
...  

ABSTRACT We determined the population pharmacokinetics of vancomycin (VAN) using the glomerular filtration rate (GFR) estimated from the serum cystatin C concentration. We examined the predictive performance of the trough serum VAN concentration for determination of the initial dose by using a new model for the analysis of the population pharmacokinetic parameters. Data for 86 patients were used to estimate the values of the population pharmacokinetic parameters. Analysis with a nonlinear mixed-effects modeling program was done by using a one-compartment model. Data for 78 patients were used to evaluate the predictive performance of the new model for the analysis of population pharmacokinetic parameters. The estimated GFR values determined by using Hoek's formula correlated linearly with VAN clearance (VAN clearance [ml/min] = 0.825 × GFR). The mean volume of distribution was 0.864 (liters/kg). The interindividual variability of VAN clearance was 19.8%. The accuracy of the prediction determined by use of the new model was statistically better than that determined by use of the Japanese nomogram-based model because the 95% confidence interval (−3.45 to −1.38) of the difference in each value of the mean absolute error (−2.41) did not include 0. Use of the serum cystatin C concentration as a marker of renal function for prediction of serum VAN concentrations may be useful.


2012 ◽  
Vol 19 (7) ◽  
pp. 712-717 ◽  
Author(s):  
Hong-Xia Guo ◽  
Chen-Hong Wang ◽  
Zhi-Quan Li ◽  
Shi-Peng Gong ◽  
Zi-Qiong Zhou ◽  
...  

2004 ◽  
Vol 36 (1) ◽  
pp. 99-101 ◽  
Author(s):  
S.H Akbas ◽  
A Yavuz ◽  
M Tuncer ◽  
C Ruhi ◽  
A Gurkan ◽  
...  

1998 ◽  
Vol 58 (7) ◽  
pp. 585-592 ◽  
Author(s):  
E. Randers ◽  
H. Kristensen ◽  
E.J Erlandsen ◽  
S Danielsen

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