scholarly journals Pharmacological Studies on Proglumetacin Maleate, a New Non-Steroidal Anti-Inflammatory Drug (4) Mode of Action on Anti-Inflammatory Activity

1986 ◽  
Vol 42 (3) ◽  
pp. 431-439 ◽  
Author(s):  
Naohiko ONO ◽  
Yasundo YAMASAKI ◽  
Noriyukl YAMAMOTO ◽  
Akihiko SUNAMI ◽  
Hidekazu MIYAKE
Keyword(s):  
Mode Of Action ◽  
Inflammatory Activity ◽  
Inflammatory Drug ◽  
Pharmacological Studies ◽  
Anti Inflammatory

Benoxaprofen (opren)

1981 ◽  
Vol 19 (24) ◽  
pp. 95-96
Keyword(s):  
Mode Of Action ◽  
Inflammatory Process ◽  
Acute Inflammation ◽  
Inflammatory Activity ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Animal Tests

Benoxaprofen (Opren - Dista) is a non-steroidal anti-inflammatory drug (NSAID) with a novel mode of action. Other NSAIDs inhibit the formation of prostaglandins which are important in acute inflammation. Benoxaprofen has little such activity, but modifies leucocyte function, especially the migration of monocytes which perpetuate the inflammatory process.1 The significance of this mode of action is unclear. In the usual animal tests of anti-inflammatory activity benoxaprofen is as effective as phenylbutazone.2

scholarly journals Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. 2. Analgesic and antipyretic effects.

1986 ◽  
Vol 88 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Naohiko ONO ◽  
Akihiko SUNAMI ◽  
Noriyuki YAMAMOTO ◽  
Yasundo YAMASAKI ◽  
Hidekazu MIYAKE
Keyword(s):  
Inflammatory Drug ◽  
Pharmacological Studies ◽  
Anti Inflammatory

scholarly journals Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. 1. Anti-inflammatory effects.

1986 ◽  
Vol 88 (1) ◽  
pp. 33-46 ◽  
Author(s):  
Naohiko ONO ◽  
Noriyuki YAMAMOTO ◽  
Akihiko SUNAMI ◽  
Yasundo YAMASAKI ◽  
Hidekazu MIYAKE
Keyword(s):  
Inflammatory Drug ◽  
Pharmacological Studies ◽  
Anti Inflammatory

scholarly journals A correlation between the species differences in anti-inflammatory activity of AD-1590, a non-steroidal anti-inflammatory drug, and its plasma level.

1988 ◽  
Vol 91 (6) ◽  
pp. 393-399
Author(s):  
Hideo NAKAMURA ◽  
Yasuhiro SETO ◽  
Satoru MOTOYOSHI ◽  
Yuichi YOKOYAMA ◽  
Toshiaki KADOKAWA
Keyword(s):  
Plasma Level ◽  
Species Differences ◽  
Inflammatory Activity ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Inhibition of Formalin Induced Paw Edema in Rats by Various Fractions/Extracts of Bryophyllum pinnatum

2019 ◽  
Vol 7 (2) ◽  
pp. 63-66
Author(s):  
R. K. Gupta ◽  
M. Lohani ◽  
R. Vishwakarma
Keyword(s):  
Rat Model ◽  
Leaf Extract ◽  
Marked Decrease ◽  
Inflammatory Diseases ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Standard Drug ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Bryophyllum Pinnatum

Traditionally, Bryophyllum pinnatum is used in the management of arthritis and inflammatory diseases. However, B. pinnatum has not been analysed previously for anti-inflammatory activity. Hence, this study is designed to determine the anti-inflammatory effects of various fractions of B. pinnatum leaf extract using rat model of formalin-induced paw edema. Treatment with various fractions showed marked decrease in formalin-induced paw volume and edema in rats. The results of BPAAF treatment were comparable to standard drug, diclofenac. These results indicate that B. pinnatum could be developed as ant-inflammatory drug after further studies.

scholarly journals In Vivo Anti-inflammatory Activity of Some Naturally Occurring O- and N-Prenyl Secondary Metabolites

2014 ◽  
Vol 9 (1) ◽  
pp. 1934578X1400900
Author(s):  
Francesco Epifano ◽  
Salvatore Genovese ◽  
Serena Fiorito ◽  
Roberto della Loggia ◽  
Aurelia Tubaro ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Acute Inflammation ◽  
Inflammatory Activity ◽  
Plant Origin ◽  
Inflammatory Drug ◽  
Naturally Occurring ◽  
Croton Oil ◽  
Anti Inflammatory

A series of O- and N-prenyl secondary metabolites of insect, fungal, and plant origin have been evaluated for their topical anti-inflammatory activity using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds revealed an effect (ID50 = 0.31 +0.56 μmol/cm2) comparable with that of the reference non-steroidal anti-inflammatory drug indomethacin (ID50 = 0.23 μmol/cm2).

scholarly journals Pharmacological studies on carprofen, a new non-steroidal anti-inflammatory drug, in animals.

1977 ◽  
Vol 73 (7) ◽  
pp. 757-777 ◽  
Author(s):  
Masaki MAEDA ◽  
Yushiro TANAKA ◽  
Tsutomu SUZUKI ◽  
Keiji NAKAMURA
Keyword(s):  
Inflammatory Drug ◽  
Pharmacological Studies ◽  
Anti Inflammatory
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