scholarly journals Pharmacological Studies on Platycodon grandiflorum A. DC. II. Anti-inflammatory Activity of Crude Platycodin, Its Activites on Isolated Organs and Other Pharmacological Activities

1972 ◽  
Vol 92 (8) ◽  
pp. 961-968 ◽  
Author(s):  
KEIJIRO TAKAGI ◽  
EUN BANG LEE
Keyword(s):  
Inflammatory Activity ◽  
Pharmacological Activities ◽  
Platycodon Grandiflorum ◽  
Isolated Organs ◽  
Pharmacological Studies ◽  
Anti Inflammatory

scholarly journals Demonstration of Phytochemicals and In-vitro Antioxidant and Anti-inflammatory activity by methanolic extract of Elettaria cardamomum

2020 ◽  
Vol 3 (3) ◽  
pp. 01-04
Author(s):  
Md. Shahidul Islam
Keyword(s):  
Methanolic Extract ◽  
Research Work ◽  
Inflammatory Activity ◽  
Pharmacological Activities ◽  
Elettaria Cardamomum ◽  
Ic50 Values ◽  
Phytochemical Profile ◽  
Anti Inflammatory ◽  
Dpph Scavenging

The existing research study attempts to untie novel avenues for development of the medicinal exercises of Elettaria cardamomum, fashionable known as the “Queen of Spices” and locally recognized as “elaichi”. Its seeds are utilized as abortifacient, acrid, alexiteric, aromatic, sweet, cardiac tonic, cooling, carminative, digestive, diuretic, expectorant, stimulant and also tonic beneficial in the asthma, haemorrhoids, bronchitis, strangury, renal in addition to vesical calculi, anorexia, halitosis, gastropathy dyspepsia as well as burning sensation. The prime goal of this research work is to evaluate antioxidant as well as anti-inflammatory properties of the traditional Bangladeshi medicinal extracts in addition to examine these activities. The aim in present work was to screen the phytochemical profile as well as pharmacological activities of the methanolic extract of this plant’s leaves. To explore pharmacological actions DPPH scavenging test and the HRBC membrane stabilization techniques were done for the antioxidant and also anti-inflammatory test respectively. The pharmacological works revealed that plant extracts might have noteworthy antioxidant effect which is possibly mediated by the inhibition of DPPH free radical which is accountable for oxidation. The IC50 values by the DPPH scavenging test observed for the standard and the leaves were 106.38µg/ml & 594.47µg/ml respectively. There is also moderate anti-inflammatory activity. The IC50 values for anti-inflammatory activity by standard & leaves were 35.04µg/ml and 944.0 µg/ml respectively.

Archidendron lucidum Exerts Anti-Inflammatory Effects by Targeting PDK1 in the NF-κB Pathway

2020 ◽  
Vol 48 (02) ◽  
pp. 429-444
Author(s):  
Minkyeong Jo ◽  
Young-Su Yi ◽  
Jae Youl Cho
Keyword(s):  
Signaling Pathway ◽  
Hplc Analysis ◽  
Inflammatory Diseases ◽  
Interleukin 1 ◽  
Inflammatory Activity ◽  
Raw264.7 Cells ◽  
Luciferase Reporter ◽  
No Production ◽  
Pharmacological Activities ◽  
Anti Inflammatory

Pharmacological activities of some Leguminosae family members were reported. Pharmacological activities of Archidendron lucidum, a Leguminosae family member have never been explored. Therefore, this study investigated anti-inflammatory effects of an Archidendron lucidum methanol extract (Al-ME). In this study, anti-inflammatory effects of Al-ME were investigated in LPS-stimulated RAW264.7 cells and HCl/EtOH-induced gastritis mice by MTT assay, nitric oxide (NO) production assay, semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), luciferase reporter assay, and Western blotting. High-performance liquid chromatography (HPLC) analysis identified ethnopharmacological compounds in Al-ME. Al-ME inhibited NO production without cytotoxicity in peritoneal macrophages and RAW264.7 cells stimulated with LPS or Pam3CSK4. Al-ME downregulated mRNA expression of inflammatory genes (inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2)) and pro-inflammatory cytokines (tumor necrosis factor-[Formula: see text] (TNF-[Formula: see text]), interleukin-1[Formula: see text] (IL-1[Formula: see text]), and IL-6). Al-ME exerted anti-inflammatory activity in LPS-stimulated RAW264.7 cells by inhibiting nuclear factor-kappa B (NF-[Formula: see text]B) signaling pathway. HPLC analysis identified quercetin, luteolin, and kaempferol as major anti-inflammatory components in Al-ME. Al-ME ameliorated HCl/EtOH-induced gastritis symptoms in mice by suppressing iNOS and IL-6 mRNA expressions and I[Formula: see text]B[Formula: see text] phosphorylation. Therefore, these results suggest that Al-ME exhibited anti-inflammatory activity by targeting NF-[Formula: see text]B signaling pathway, implying that Al-ME could be potent anti-inflammatory medications to prevent and treat inflammatory diseases.

A Concise overview of phytochemistry, pharmacology and clinical aspects of Persian Cumin; Bunium persicum (Boiss.) B.Fedtsch

2020 ◽  
Vol 17 ◽  
Author(s):  
Mahkameh Moradi Mehrabadi ◽  
Mohammad M. Zarshenas
Keyword(s):  
Experimental Investigations ◽  
Clinical Aspects ◽  
Pharmacological Activities ◽  
Important Species ◽  
Bunium Persicum ◽  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Antimicrobial And Antifungal Activities ◽  
Phenolic And Flavonoid ◽  
Phenolic And Flavonoid Compounds

: Bunium persicum is one of the most medically and economically important species of Apiaceae family. Despite variety of phytochemical and experimental research on this species, there is no considerable update on all related outcomes. Accordingly, current work compiles an overview on Cumin’s phytochemical and pharmacological activities. Papers related to phytochemistry, pharmacology and clinical properties of B. persicum were filtered from databases as PubMed, ScienceDirect and Scopus with the term "Bunium persicum" till 15th May 2020. Genetic, pure pharmaceutical and agriculture papers were excluded. Moreover, traditional applications of this herb in Persian medicine were studied and included. In all, 54 papers reporting the compositions, Anticonvulsant, antinociceptive, anti-inflammatory, antioxidant, anti-glycation, antidiarrhea, anti-hematotoxic, anti-toxoplasmosis, hypoglycemic, larvicidal, scolicidal, anticholinergic and antihistaminic activities of B. persicum as well as reducing and stabilizing effects in nanoparticles. Three clinical trials have also been conducted on B. persicum. There are also numerous effects, cited in traditional manuscripts such as gastroprotective, kidney tonic, slimming activity and antidote for poisons. Most dominant chemical composition of Cumin is the essential oil, responsible for various potent antimicrobial and antifungal activities. The herb also contain phenolic and flavonoid compounds which reflect the antioxidant and anti-inflammatory activities. Many of the experimental and pharmacological studies on B. persicum have traces in traditional manuscripts. There are also medical aspects which have not yet been evaluated. Despite various experimental investigations, lack of extensive clinical studies which is currently limited to few trials on remarked activities of B. persicum is still remained to be covered.

scholarly journals Chemical Constituents and Pharmacological Activities of Steroid Saponins Isolated from Rhizoma Paridis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Fen Liu ◽  
Luning Li ◽  
Xinchen Tian ◽  
Dengtian Zhang ◽  
Wenxue Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Animal Models ◽  
Chemical Constituents ◽  
Herbal Drugs ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
Comprehensive Exploitation ◽  
Paris Polyphylla ◽  
Pharmacological Studies ◽  
Anti Inflammatory

Rhizoma Paridis, the rhizome of liliaceous plants Paris polyphylla, is one of the most commonly used herbal drugs in China. Phytochemical and pharmacological studies have shown that steroid saponins were the major effective ingredients of Rhizoma Paridis to exert antitumor, anti-inflammatory, hemostasis, and antifibrosis functions. In this review, we discussed the chemical structures of steroid saponins and their related biological activity and mechanisms in cellular and animal models, aiming to provide a reference for future comprehensive exploitation and development of saponins.

scholarly journals In vitro and in vivo anti-inflammatory activity of Dillenia pentagyna Roxb. bark, a folklore medicine of Mizoram

2017 ◽  
Vol 17 (2) ◽  
pp. 69-77
Author(s):  
Zothanpuia ◽  
Bibhuti K. Kakoti
Keyword(s):  
Methanolic Extract ◽  
Inflammatory Activity ◽  
Endangered Plants ◽  
Pharmacological Activities ◽  
North East India ◽  
Rich Variety ◽  
North East ◽  
Anti Inflammatory

Natural products have played an exceptionally important role in health care and prevention of diseases for thousands of years and are one of the greatest sources of medicine. Mizoram is a home to a rich variety of flora and fauna however; very less systematic survey and documentation were carried out to date. The plant diversity of Mizoram is not adequately studied as compared to other states of north east India. Dillenia pentagyna Roxb., known as kaihzawl in Mizo and dog teak in English, is one of the endangered plants that is yet to be explore. The Mizo communities use the decoction of D. pentagyna bark to treat different stomach ailments, inflammation and diabetes. In this perspective, the methanolic extract of the bark of D. pentagyna was evaluated for its anti-inflammatory properties. The extract showed the presence of flavanoids, triterpenoids, steroids, phenolics, saponins, fixed oils and others exerting varied pharmacological activities. The methanolic extract of this plant was found to contain active constituents such as betulinic acid and β-sitosterol which are found to actively interact with the inflammatory mediators and suppressed the inflammation when evaluated for its in vitro and in vivo anti-inflammatory activity. The present study suggests that the methanolic extract of D. pentagyna bark showed significant anti-inflammatory activity. This study also support the folkloric used of the plant in diseases related to inflammatory condition.

scholarly journals Tabebuia impetiginosa: A Comprehensive Review on Traditional Uses, Phytochemistry, and Immunopharmacological Properties

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4294 ◽  
Author(s):  
Jianmei Zhang ◽  
Stephanie Triseptya Hunto ◽  
Yoonyong Yang ◽  
Jongsung Lee ◽  
Jae Youl Cho
Keyword(s):  
Skin Diseases ◽  
Fungal Infections ◽  
Scientific Evidence ◽  
Inflammatory Activity ◽  
Future Research ◽  
Pharmacological Activities ◽  
Traditional Uses ◽  
New Strategy ◽  
Anti Inflammatory ◽  
Underlying Mechanisms

Tabebuia impetiginosa, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases. Additionally, several categories of phytochemicals and extracts isolated from T. impetiginosa have been studied via various models and displayed pharmacological activities. This review aims to uncover and summarize the research concerning T. impetiginosa, particularly its traditional uses, phytochemistry, and immunopharmacological activity, as well as to provide guidance for future research. A comprehensive search of the published literature was conducted to locate original publications pertaining to T. impetiginosa up to June 2020. The main inquiry used the following keywords in various combinations in titles and abstracts: T. impetiginosa, Taheebo, traditional uses, phytochemistry, immunopharmacological, anti-inflammatory activity. Immunopharmacological activity described in this paper includes its anti-inflammatory, anti-allergic, anti-autoimmune, and anti-cancer properties. Particularly, T. impetiginosa has a strong effect on anti-inflammatory activity. This paper also describes the target pathway underlying how T. impetiginosa inhibits the inflammatory response. The need for further investigation to identify other pharmacological activities as well as the exact target proteins of T. impetiginosa was also highlighted. T. impetiginosa may provide a new strategy for prevention and treatment of many immunological disorders that foster extensive research to identify potential anti-inflammatory and immunomodulatory compounds and fractions as well as to explore the underlying mechanisms of this herb. Further scientific evidence is required for clinical trials on its immunopharmacological effects and safety.

scholarly journals Pharmacological evaluation of oxazine sulfonamide derivatives for anti-inflammatory, analgesic and antipyretic activities

2016 ◽  
Vol 4 (2) ◽  
pp. 111 ◽  
Author(s):  
Shailaja Ande ◽  
Khadar Shaik ◽  
Ravi Dharmoji ◽  
Nisa Firdouse ◽  
Anjum Mohd ◽  
...  
Keyword(s):  
Nitrogen Atom ◽  
Heterocyclic Compound ◽  
Analgesic Effect ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Pharmacological Activities ◽  
Antipyretic Activity ◽  
Pharmacological Evaluation ◽  
Albino Mice ◽  
Anti Inflammatory

Oxazine heterocyclic compound containing one oxygen and one nitrogen atom. They possess different pharmacological activities like anticancer, anti-ulcer, antifungal, antithrombotic, antihypertensive, analgesic, anti-inflammatory etc. Oxazine Sulphonamide derivatives were investigated for anti-inflammatory, analgesic and anti-pyretic activities. It was evaluated for anti-inflammatory activity by carrageenan induced paw edema in rats using Plethysmometer and it also shows significant analgesic effect in male Albino mice. Antipyretic activity was also investigated.

Tenuigenin exhibits anti-inflammatory activity via inhibiting MAPK and NF-κB and inducing Nrf2/HO-1 signaling in macrophages

2016 ◽  
Vol 7 (1) ◽  
pp. 355-363 ◽  
Author(s):  
Hongming Lv ◽  
Wenzhi Ren ◽  
Yuwei Zheng ◽  
Lidong Wang ◽  
Gejin Lu ◽  
...  
Keyword(s):  
Chinese Herb ◽  
Inflammatory Activity ◽  
Pharmacological Activities ◽  
Polygala Tenuifolia ◽  
Anti Inflammatory ◽  
Anti Inflammation ◽  
Biological And Pharmacological Activities

Tenuigenin (TNG), isolated from the root of the Chinese herb Polygala tenuifolia, possesses various biological and pharmacological activities, including anti-oxidation and anti-inflammation activities.

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