scholarly journals Imaging features of primary and metastatic alveolar soft part sarcoma: single institute experience in 25 patients

2014 ◽  
Vol 87 (1036) ◽  
pp. 20130719 ◽  
Author(s):  
S Sood ◽  
A D Baheti ◽  
A B Shinagare ◽  
J P Jagannathan ◽  
J L Hornick ◽  
...  
Keyword(s):  
Soft Part ◽  
Alveolar Soft Part Sarcoma ◽  
Imaging Features

scholarly journals Imaging Features of Alveolar Soft-Part Sarcoma: A Report From Children's Oncology Group Study ARST0332

2014 ◽  
Vol 203 (6) ◽  
pp. 1345-1352 ◽  
Author(s):  
M. Beth McCarville ◽  
Sofia Muzzafar ◽  
Simon C. Kao ◽  
Cheryl M. Coffin ◽  
David M. Parham ◽  
...  
Keyword(s):  
Soft Part ◽  
Alveolar Soft Part Sarcoma ◽  
Imaging Features ◽  
Oncology Group ◽  
Oncology Group Study

scholarly journals Imaging and Pathological Features of Alveolar Soft Part Sarcoma: Analysis of 16 Patients

2021 ◽  
Author(s):  
Malvika Gulati ◽  
Abhenil Mittal ◽  
Adarsh Barwad ◽  
Rambha Pandey ◽  
Sameer Rastogi ◽  
...  
Keyword(s):  
Young Adults ◽  
Soft Tissue ◽  
Soft Part ◽  
Alveolar Soft Part Sarcoma ◽  
Preoperative Imaging ◽  
Histopathological Diagnosis ◽  
Imaging Features ◽  
Common Site ◽  
Hyperintense Signal ◽  
Characteristic Imaging

Abstract Context Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor most commonly occurring in deep intramuscular plane of lower extremities of adolescents and young adults. It is a highly vascular, slow growing tumor with malignant potential having lung as the most common site of metastases at the time of presentation. Aims The aim is to review the imaging findings of ASPS and determine characteristic imaging features of this rare tumor. Materials and Methods Sixteen patients having histopathological diagnosis and preoperative imaging of ASPS attending the dedicated sarcoma clinic at our institute were included in the study. The demographic, clinical, and imaging data were retrieved from the case records and then evaluated for characteristic imaging features which may raise suspicion of ASPS. Results The patients ranged from 3 to 72 years of age and with a slight male preponderance. Of the eight CECTs evaluated, 62.5% tumors showed well-defined lobulated margins, 87.5% cases showed intense enhancement with presence of feeder vessels. On CEMRI of 10 patients, 70% had well circumscribed lobulated margins with intense enhancement and tortuous flow voids in most of them. All cases showed T2 hyperintense signal. Fourteen of 16 (87.5%) patients had metastatic disease with lung as the most common site (92.8%). Conclusion ASPS is a rare soft tissue sarcoma seen in children and young adults. Imaging may mimic a vascular malformation due to the presence of tortuous feeders. Misdiagnosis at an early stage may lead to later metastatic presentation of the disease, thus emphasizing the need to suspect it on imaging.

scholarly journals iCREATE: imaging features of primary and metastatic alveolar soft part sarcoma from the EORTC CREATE study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Naami Charlotte Mcaddy ◽  
Hind Saffar ◽  
Saskia Litière ◽  
Pieter Jespers ◽  
Patrick Schöffski ◽  
...  
Keyword(s):  
Pulmonary Metastases ◽  
Soft Part ◽  
Primary Tumour ◽  
High Rate ◽  
Alveolar Soft Part Sarcoma ◽  
Imaging Features ◽  
Antiangiogenic Treatment ◽  
Feeding Vessels ◽  
Slow Growing ◽  
Sites Of Metastases

Abstract Background Alveolar Soft Part Sarcoma (ASPS) is a rare, slow-growing, but highly vascular soft tissue sarcoma, characterised by a high rate of metastases at presentation. Although imaging features of the primary are well described, less detail is available on the imaging pattern of metastatic ASPS. The EORTC 90101 (CREATE) study assessed the efficacy of Crizotinib in patients with metastatic ASPS and presents a unique opportunity to describe the imaging phenotype of primary and metastatic ASPS, based on prospectively collected imaging. Methods A retrospective review of the staging CT scans of 32 patients with ASPS from the CREATE study was undertaken and the imaging features of primary and metastatic disease were assessed. Results Imaging of the primary tumour was available in 7/32 cases (28%). All primary tumours demonstrated marked vascularity with prominent feeding vessels (7/7, 100%). The most frequent sites of metastases included lung (30/32, 94%), nodal (7/32, 22%), bone (5/32, 16%) and muscle/subcutaneous (5/32, 16%). Features of hypervascularity were identified at all sites, more appreciable in the lungs, with feeding vessels frequently demonstrated in pulmonary metastases (21/32, 66%). Conclusion Analysis of imaging from the CREATE cohort of patients with metastatic ASPS demonstrates that metastases from ASPS are predominantly hypervascular and demonstrate feeding vessels comparable to primary ASPS, suggesting potential sensitivity of this rare sarcoma for antivascular/antiangiogenic treatment approaches.

scholarly journals Alveolar Soft Part Sarcoma of the Oro-Maxillofacial Region in the Pediatric Age Group: Immunohistochemical and Ultrastructural Diagnosis of Two Cases

2021 ◽  
Author(s):  
Rimlee Dutta ◽  
Aanchal Kakkar ◽  
Pirabu Sakthivel ◽  
Rajeev Kumar ◽  
Rachna Seth ◽  
...  
Keyword(s):  
Soft Part ◽  
Alveolar Soft Part Sarcoma ◽  
Age Group ◽  
Pediatric Age ◽  
Maxillofacial Region ◽  
Pediatric Age Group

Alveolar soft-part sarcoma

1990 ◽  
Vol 26 (4) ◽  
pp. 783
Author(s):  
S H Jung ◽  
D W Sung ◽  
Y Yoon ◽  
W S Choi ◽  
J H Lim ◽  
...  
Keyword(s):  
Soft Part ◽  
Alveolar Soft Part Sarcoma

scholarly journals Dual-color, Break-apart FISH Assay on Paraffin-embedded Tissues as an Adjunct to Diagnosis of Xp11 Translocation Renal Cell Carcinoma and Alveolar Soft Part Sarcoma

2010 ◽  
Vol 34 (6) ◽  
pp. 757-766 ◽  
Author(s):  
Minghao Zhong ◽  
Patricia De Angelo ◽  
Lisa Osborne ◽  
Megan Keane-Tarchichi ◽  
Michael Goldfischer ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Soft Part ◽  
Alveolar Soft Part Sarcoma ◽  
Dual Color

Durable clinical activity of single-agent bevacizumab in a nonagenarian patient with metastatic alveolar soft part sarcoma

2012 ◽  
Vol 23 (7) ◽  
pp. 745-748 ◽  
Author(s):  
Olivier Mir ◽  
Pascaline Boudou-Rouquette ◽  
Frédérique Larousserie ◽  
Benoit Blanchet ◽  
Antoine Babinet ◽  
...  
Keyword(s):  
Soft Part ◽  
Single Agent ◽  
Alveolar Soft Part Sarcoma ◽  
Clinical Activity
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