Meta-analysis of diagnostic value of18F-FDG PET or PET/CT for detecting lymph node and distant metastases in patients with nasopharyngeal carcinoma

Abstract Objective This article aims to evaluate the diagnostic value of 68Gallium-PSMA positron emission tomography/computerized tomography (68Ga-PSMA PET/CT) for lymph node (LN) staging in patients with prostate cancer (PCa) by a meta-analysis of diagnostic tests. Methods We systematically retrieved articles from Web of Science, EMBASE, Cochrane Database, PubMed. The time limit is from the creation of the database until June 2019, and Stata 15 was used for calculation and statistical analyses. Results Sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR), diagnostic odds ratio (DOR) and 95% confidence intervals (CI) be used to evaluate the diagnostic value. A total of 10 studies were included in our meta-analysis, which included 701 individuals. The results of each consolidated summary are as follows: sensitivity of 0.84 (95% CI 0.55–0.95), specificity of 0.95 (95% CI 0.87–0.98), PLR and NLR was 17.19 (95% CI 6.27, 47.17) and 0.17 (95% CI 0.05–0.56), respectively. DOR of 100 (95% CI 18–545), AUC of 0.97 (95% CI 0.95–0.98). Conclusion Our study demonstrates that 68Ga-PSMA PET/CT has a high overall diagnostic value for LN staging in patients with moderate and high-risk PCa. But our conclusions still require a larger sample size, multi-center prospective randomized controlled trial to verify.

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The accuracy of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in the staging of newly diagnosed nasopharyngeal carcinoma: A systematic review and meta-analysis.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.5553 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. 5553-5553

Author(s):

Balamurugan A. Vellayappan ◽

Yu Yang Soon ◽

Arul Earnest ◽

Qing Zhang ◽

Wee Yao Koh ◽

...

Keyword(s):

Systematic Review ◽

Nasopharyngeal Carcinoma ◽

Fdg Pet ◽

Meta Analysis ◽

Newly Diagnosed ◽

Pet Ct ◽

Q Index ◽

T Classification ◽

Fdg Pet Ct ◽

Sensitivity Estimate

5553 Background: The specific role of FDG-PET/CT in pretreatment staging of nasopharyngeal carcinoma (NPC) remains to be validated. We performed a systematic review and meta-analysis to assess the diagnostic accuracy of staging FDG-PET/CT for newly diagnosed NPC with reference to conventional staging modalities and/or clinical follow up. Methods: We searched MEDLINE, Cochrane central register of controlled trials, proceedings of ASTRO and ASCO as well as Chinese databases (Chinese National Knowledge Infrastructure and CBMdisc) from the date of inception to September 2011 for relevant studies. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) checklist. We determined the sensitivities and specificities across studies, pooled diagnostic odds ratios (DOR) and constructed summary receiver operating characteristic curves using hierarchical regression model. Results: We found 15 relevant studies (of which seven were in English) including 851 patients. Of the 15 studies: five addressed primary tumor (T), nine addressed regional lymph nodes (N) and seven addressed distant metastasis (M). The combined sensitivity estimate for FDG-PET/CT in T classification was 0.77(95% confidence interval (CI) 0.59-0.95). The combined sensitivity estimate for N classification was 0.88 (95% CI 0.86-0.90), specificity 0.85(95% CI 0.83-0.88), DOR 82.4 (23.2 to 292.6) and Q-index was 0.90. For M classification, the combined sensitivity estimate was 0.82(95% CI 0.65-0.93), specificity 0.98 (95% CI 0.96 – 0.99), DOR 120.9 (43.0 to 340.0) and Q-index was 0.89. Conclusions: FDG-PET/CT showed good accuracy in N and M but not T classification for newly diagnosed pre-treated NPC. FDG-PET/CT, together with Magnetic resonance imaging (MRI) of the nasopharynx, should be part of the routine staging investigations for NPC. Future research should evaluate the accuracy of FDG-PET/MRI fusion as a single staging modality for NPC.

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A systematic review and meta-analysis of pretherapeutic lymph node staging of colorectal cancer by 18F-FDG PET or PET/CT

Nuclear Medicine Communications ◽

10.1097/mnm.0b013e328357b2d9 ◽

2012 ◽

Vol 33 (11) ◽

pp. 1127-1133 ◽

Cited By ~ 41

Author(s):

Yu-Yu Lu ◽

Jin-Hua Chen ◽

Hueisch-Jy Ding ◽

Chun-Ru Chien ◽

Wan-Yu Lin ◽

...

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Lymph Node ◽

Fdg Pet ◽

Meta Analysis ◽

Lymph Node Staging ◽

Pet Ct ◽

18F Fdg

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Diagnostic value of using 18F-FDG PET and PET/CT in immunocompetent patients with primary central nervous system lymphoma: A systematic review and meta-analysis

Oncotarget ◽

10.18632/oncotarget.17456 ◽

2017 ◽

Vol 8 (25) ◽

pp. 41518-41528 ◽

Cited By ~ 16

Author(s):

Yaru Zou ◽

Jianjing Tong ◽

Haiyan Leng ◽

Jingwei Jiang ◽

Meng Pan ◽

...

Keyword(s):

Systematic Review ◽

Central Nervous System ◽

Nervous System ◽

Fdg Pet ◽

Meta Analysis ◽

Central Nervous System Lymphoma ◽

Diagnostic Value ◽

Pet Ct ◽

18F Fdg ◽

Immunocompetent Patients

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PD-0465: MRI may replace FDG-PET/CT for selective lymph node irradiation in NSCLC radiotherapy: results of a meta-analysis

Radiotherapy and Oncology ◽

10.1016/s0167-8140(15)40461-x ◽

2015 ◽

Vol 115 ◽

pp. S229-S230

Author(s):

J. Peerlings ◽

E. Troost ◽

P. Nelemans ◽

R. Beets-Tan ◽

A. Hoffmann

Keyword(s):

Lymph Node ◽

Fdg Pet ◽

Meta Analysis ◽

Pet Ct ◽

Fdg Pet Ct ◽

Lymph Node Irradiation

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Prognostic value of 18F-FDG-PET/CT in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

Oncotarget ◽

10.18632/oncotarget.13934 ◽

2016 ◽

Vol 8 (20) ◽

pp. 33884-33896 ◽

Cited By ~ 18

Author(s):

Jie Lin ◽

Guozhu Xie ◽

Guixiang Liao ◽

Baiyao Wang ◽

Miaohong Yan ◽

...

Keyword(s):

Systematic Review ◽

Nasopharyngeal Carcinoma ◽

Fdg Pet ◽

Prognostic Value ◽

Meta Analysis ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Accuracy of whole-body FDG-PET and FDG-PET/CT in M staging of nasopharyngeal carcinoma: A systematic review and meta-analysis

European Journal of Radiology ◽

10.1016/j.ejrad.2012.06.031 ◽

2013 ◽

Vol 82 (2) ◽

pp. 366-373 ◽

Cited By ~ 29

Author(s):

Ming-Che Chang ◽

Jin-Hua Chen ◽

Ji-An Liang ◽

Kuang-Tao Yang ◽

Kai-Yuan Cheng ◽

...

Keyword(s):

Systematic Review ◽

Nasopharyngeal Carcinoma ◽

Fdg Pet ◽

Meta Analysis ◽

Whole Body ◽

Pet Ct ◽

Fdg Pet Ct

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Diagnostic value of [18F]FDG-PET/CT in polymyalgia rheumatica: a systematic review and meta-analysis

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-020-05162-6 ◽

2020 ◽

Author(s):

K. S. M. van der Geest ◽

G. Treglia ◽

A. W. J. M. Glaudemans ◽

E. Brouwer ◽

F. Jamar ◽

...

Keyword(s):

Systematic Review ◽

Polymyalgia Rheumatica ◽

Fdg Pet ◽

Meta Analysis ◽

Diagnostic Value ◽

Current Evidence ◽

Interpretation Criteria ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Abstract Purpose Polymyalgia rheumatica (PMR) can be difficult to diagnose. Whole-body [18F]FDG-PET/CT allows for a comprehensive evaluation of all relevant articular and extra-articular structures affected by PMR. We aimed to summarize current evidence on the diagnostic value of [18F]FDG-PET/CT for a diagnosis of PMR. Methods PubMed/MEDLINE and the Cochrane Library database were searched from inception through May 31, 2020. Studies containing patients with PMR who underwent [18F]FDG-PET/CT were included. Screening and full-text review were performed by 3 investigators and data extraction by 2 investigators. Risk of bias was examined with the QUADAS-2 tool. Diagnostic test meta-analysis was performed with a bivariate model. Results Twenty studies were included in the systematic review, of which 9 studies (n = 636 patients) were eligible for meta-analysis. [18F]FDG positivity at the following sites was associated with a diagnosis of PMR: interspinous bursae (positive likelihood ratio (LR+) 4.00; 95% CI 1.84–8.71), hips (LR+ 2.91; 95% CI 2.09–4.05), ischial tuberosities (LR+ 2.86; 95% CI 1.91–4.28), shoulders (LR+ 2.57; 95% CI 1.24–5.32) and sternoclavicular joints (LR+ 2.31; 95% CI 1.33–4.02). Negative likelihood ratios (LR−) for these sites, as well as the greater trochanters, were all less than 0.50. Composite [18F]FDG-PET/CT scores, as reported in 3 studies, provided a pooled LR+ of 3.91 (95% CI 2.42–6.32) and LR− of 0.19 (95% CI 0.10–0.36). Moderate to high heterogeneity was observed across the studies, mainly due to differences in patient selection, scanning procedures and/or interpretation criteria. Conclusion Significant [18F]FDG uptake at a combination of anatomic sites is informative for a diagnosis of PMR. [18F]FDG-PET/CT might be an important diagnostic tool in patients with suspected PMR. This study also highlights the need for adherence to published procedural recommendations and standardized interpretation criteria for the use of [18F]FDG-PET/CT in PMR.

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A Head-to-Head Comparison of 68Ga-DOTA-FAPI-04 and 18F-FDG PET/MR in Patients with Nasopharyngeal Carcinoma: A Prospective Study

10.21203/rs.3.rs-252484/v1 ◽

2021 ◽

Author(s):

Chunxia Qin ◽

Fang Liu ◽

Jing Huang ◽

Weiwei Ruan ◽

Qingyao Liu ◽

...

Keyword(s):

Lymph Node ◽

Nasopharyngeal Carcinoma ◽

Lymph Nodes ◽

Skull Base ◽

Primary Tumor ◽

Fdg Pet ◽

Distant Metastases ◽

Tracer Uptake ◽

Visual Evaluation ◽

Primary Tumors

Abstract PurposeTo conduct a head-to-head comparison of the diagnostic ability of 68Ga-DOTA-FAPI-04 (68Ga-FAPI) and 18F-FDG PET/MR in nasopharyngeal carcinoma (NPC) patients.MethodsPatients diagnosed with NPC were prospectively enrolled. All patients underwent head-and-neck 68Ga-FAPI PET/MR and 18F-FDG PET/MR within one week. Primary tumor, lymph node numbers, and tracer uptake were compared by SUVmax and visual evaluation. The primary tumor volumes derived from 68Ga-FAPI, 18F-FDG PET, and MRI were also compared.ResultsFifteen patients were enrolled from June to August 2020. Both 68Ga-FAPI and 18F-FDG PET had 100% detection rate of the primary tumor. The 68Ga-FAPI SUVmax of primary tumors (13.87±5.13) was lower than that of 18F-FDG (17.73±6.84), but the difference was not significant (p=0.078). Compared with 18F-FDG, 68Ga-FAPI PET improved the delineation of skull-base invasion in eight out of eight patients and intracranial invasion in four out of four patients. When 25%SUVmax of 68Ga-FAPI or 20%SUVmax of 18F-FDG was utilized as a threshold for determining tumor volume, it was highly consistent with MRI. 18F-FDG PET detected much more positive lymph nodes than 68Ga-FAPI (100 vs 48). The SUVmax of 48 paired lymph nodes was significantly lower on 68Ga-FAPI than 18F-FDG (8.67±3.88 vs 11.79±6.17, p<0.001). Additionally, 68Ga-FAPI further detected four highly suspected small, distant metastases in three patients. Compared with 18F-FDG, 68Ga-FAPI changed overall staging in six of fifteen patients, with three patients being up-staged, and three down-staged.Conclusion68Ga-FAPI outperforms 18F-FDG in delineating the primary tumor and detecting suspected distant metastases, particularly in the evaluation of skull-base and intracranial invasion, suggesting 68Ga-FAPI hybrid PET/MR has the potential to serve as a single-step staging modality for patients with NPC. However, its value regarding lymph node and distant metastases evaluation needs further study.Trial registration: NCT04554719. Registered September 8, 2020 - retrospectively registered, http://clinicaltrails.gov/show/ NCT04554719

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