A Case Series of Adult Patients Diagnosed with IgA Vasculitis Requiring Systemic Immunosuppression

Abstract Objective: We evaluated the risk of patients contracting coronavirus disease 2019 (COVID-19) during their hospital stay to inform the safety of hospitalization for a non–COVID-19 indication during this pandemic. Methods: A case series of adult patients hospitalized for 2 or more nights from May 15 to June 15, 2020 at large tertiary-care hospital in the midwestern United States was reviewed. All patients were screened at admission with the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) polymerase chain reaction (PCR) test. Selected adult patients were also tested by IgG serology. After dismissal, patients with negative serology and PCR at admission were asked to undergo repeat serologic testing at 14–21 days after discharge. The primary outcome was healthcare-associated COVID-19 defined as a new positive SARS-CoV-2 PCR test on or after day 4 of hospital stay or within 7 days of hospital dismissal, or seroconversion in patients previously established as seronegative. Results: Of the 2,068 eligible adult patients, 1,778 (86.0%) completed admission PCR testing, while 1,339 (64.7%) also completed admission serology testing. Of the 1,310 (97.8%) who were both PCR and seronegative, 445 (34.0%) repeated postdischarge serology testing. No healthcare-associated COVID-19 cases were detected during the study period. Of 1,310 eligible PCR and seronegative adults, no patients tested PCR positive during hospital admission (95% confidence interval [CI], 0.0%–0.3%). Of the 445 (34.0%) who completed postdischarge serology testing, no patients seroconverted (0.0%; 95% CI, 0.0%–0.9%). Conclusion: We found low likelihood of hospital-associated COVID-19 with strict adherence to universal masking, physical distancing, and hand hygiene along with limited visitors and screening of admissions with PCR.

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Macrophage Activation Syndrome in Adults: A Retrospective Case Series

Journal of Investigative Medicine High Impact Case Reports ◽

10.1177/23247096211026406 ◽

2021 ◽

Vol 9 ◽

pp. 232470962110264

Author(s):

Taylor Warmoth ◽

Malvika Ramesh ◽

Kenneth Iwuji ◽

John S. Pixley

Keyword(s):

Macrophage Activation Syndrome ◽

Macrophage Activation ◽

Pediatric Patients ◽

Inflammatory Diseases ◽

Systemic Juvenile Idiopathic Arthritis ◽

Case Series ◽

Adult Patients ◽

Retrospective Case ◽

Life Threatening ◽

Activation Syndrome

Macrophage activation syndrome (MAS) is a form of hemophagocytic lymphohistocytosis that occurs in patients with a variety of inflammatory rheumatologic conditions. Traditionally, it is noted in pediatric patients with systemic juvenile idiopathic arthritis and systemic lupus erythematous. It is a rapidly progressive and life-threatening syndrome of excess immune activation with an estimated mortality rate of 40% in children. It has become clear recently that MAS occurs in adult patients with underlying rheumatic inflammatory diseases. In this article, we describe 6 adult patients with likely underlying MAS. This case series will outline factors related to diagnosis, pathophysiology, and review present therapeutic strategies.

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SP119ADULT-ONSET IGA VASCULITIS TREATED WITH RITUXIMAB. A CASE SERIES

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfx141.sp119 ◽

2017 ◽

Vol 32 (suppl_3) ◽

pp. iii145-iii145 ◽

Cited By ~ 1

Author(s):

F Maritati ◽

R Fenoglio ◽

E Pillebout ◽

G Emmi ◽

ML Urban ◽

...

Keyword(s):

Case Series ◽

Iga Vasculitis

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Do femoral fractures in adult patients with osteogenesis imperfecta imitate atypical femoral fractures? A case series

Osteoporosis International ◽

10.1007/s00198-018-4769-1 ◽

2018 ◽

Vol 30 (2) ◽

pp. 513-517 ◽

Cited By ~ 3

Author(s):

J. D. Andersen ◽

M. H. Bünger ◽

O. Rahbek ◽

J. D. Hald ◽

T. Harsløf ◽

...

Keyword(s):

Osteogenesis Imperfecta ◽

Case Series ◽

Femoral Fractures ◽

Adult Patients ◽

Atypical Femoral Fractures

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Ingestion and Pharyngeal Trauma Causing Secondary Retropharyngeal Abscess in Five Adult Patients

Case Reports in Emergency Medicine ◽

10.1155/2012/943090 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Sudhir B. Sharma ◽

Paul Hong

Keyword(s):

Emergency Medicine ◽

Foreign Body ◽

Clinical Features ◽

Case Series ◽

Adult Patients ◽

Retropharyngeal Abscess ◽

Emergency Medicine Physician ◽

Medicine Physician ◽

Local Trauma ◽

Pertinent Information

Retropharyngeal abscess most commonly occurs in children. When present in adults the clinical features may not be typical, and associated immunosuppression or local trauma can be part of the presentation. We present a case series of five adult patients who developed foreign body ingestion trauma associated retropharyngeal abscess. The unusual pearls of each case, along with their outcomes, are discussed. Pertinent information for the emergency medicine physician regarding retropharyngeal abscess is presented as well.

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MicroRNA expression in the affected skin of adult patients with IgA vasculitis

Clinical Rheumatology ◽

10.1007/s10067-018-4250-8 ◽

2018 ◽

Vol 38 (2) ◽

pp. 339-345 ◽

Cited By ~ 2

Author(s):

Alojzija Hočevar ◽

Matija Tomšič ◽

Jože Pižem ◽

Luka Bolha ◽

Snežna Sodin-Šemrl ◽

...

Keyword(s):

Microrna Expression ◽

Adult Patients ◽

Iga Vasculitis

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MO291RITUXIMAB IS EFFECTIVE AND SAFE IN ADULTS WITH STEROID-DEPENDENT NEPHROTIC SYNDROME: A LONG-TERM, SINGLE-CENTER EXPERIENCE

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfab104.0049 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

Gemma Patella ◽

Alessandro Comi ◽

Giuseppe Coppolino ◽

Nicolino Comi ◽

Giorgio Fuiano ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Case Series ◽

Adult Patients ◽

Single Center ◽

Single Center Experience ◽

Steroid Dependent ◽

The Mean ◽

Steroid Dependent Nephrotic Syndrome

Abstract Background and Aims Steroid-dependent nephrotic syndrome (SDNS) may require a prolonged multi-drug therapy with risk of drug toxicity and renal failure. Rituximab (RTX) treatment has been found to be helpful in reducing the steroid dosage and the need for immunosuppressants (ISs), but little data are currently available regarding very long-term outcomes in adults. We herein describe a long-term, single-center experience of RTX use in a large series of adults with SDNS. Method We studied 23 adult patients with SDNS (mean age 54.2±17.1 y; 65% male; BMI 28.5±4.7), mostly consequent to membranous (47.8%) or focal glomerulonephritis (30.2 %) who were eligible to start a RTX regimen. Before entering the RTX protocol, proteinuria and eGFR were 7.06±3.87 g/24h and 65.9±28.2 ml/min/1.73 m2, respectively; albumin and CD19/CD20 ratio were 2.9±0.9 g/L and 0.99±0.01 respectively; the mean number of ISs was 2.39±0.89 and the mean annual rate of relapses was 2.2±0.9. Results Patients were followed over a mean follow-up of 64 months (range: 12-144). After RTX (mean dose: 1202.1±372.4 mg) the rate of relapses was virtually nullified (p<0.001). eGFR remained roughly stable (62.1±19.8 ml/min/1.73 m2, p=NS), while proteinuria, albumin, CD19/CD20 and BMI all significantly improved (p ranging from 0.01 to 0.001). The mean number of additional ISs was also reduced (0.44±0.12; p<0.001) and RTX enabled discontinuation of steroids in 13/23 (56.5%) patients. No major adverse events related to therapy were recorded. Conclusion Findings from this large case-series with a remarkable very long follow-up reinforce the role of RTX as an efficient and safe weapon to improve outcomes in adult patients suffering from SDNS.

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BCOR Alterations in Pediatric and Young Adult Patients With Sarcomas and High-Grade Glial Malignancies: A Case Series

JCO Precision Oncology ◽

10.1200/po.19.00116 ◽

2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Nikhil P. Mankuzhy ◽

Bailey Anderson ◽

Chandan Kumar ◽

Amer Heider ◽

Carl Koschmamn ◽

...

Keyword(s):

Young Adult ◽

Case Series ◽

Adult Patients ◽

High Grade

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Assessment of 30-Day Adverse Events in Single-Event, Multilevel Upper Extremity Surgery in Adult Patients with Upper Motor Neuron Syndrome

Hand ◽

10.1177/1558944720975151 ◽

2020 ◽

pp. 155894472097515

Author(s):

Raahil Patel ◽

Peter C. Rhee

Keyword(s):

Adverse Events ◽

Motor Neuron ◽

Upper Extremity ◽

Intraoperative Complications ◽

Hospital Readmissions ◽

Case Series ◽

Adult Patients ◽

Minimal Risk ◽

Single Event ◽

Cord Injury

Background: Upper motor neuron (UMN) syndrome consists of muscle spasticity, weakness, and dyssynergy due to a brain or spinal cord injury. The purpose of this study is to describe the perioperative adverse events for adult patients undergoing single-event, multilevel upper extremity surgery (SEMLS) due to UMN syndrome. Methods: A retrospective case series was performed for 12 consecutive adult patients who underwent SEMLS to correct upper extremity dysfunction or deformity secondary to UMN syndrome. The evaluation consisted of primary outcome measures to identify readmission rates and classify adverse events that occurred within 30 days after surgery. Results: All 12 patients were functionally dependent with 50% (n = 6) men and 50% (n = 6) women at a mean age of 43.6 years (range: 21-73) with a mean of 5.92 (range: 0-16) comorbid diagnoses at the time of surgery. There were no intraoperative complications, hospital readmissions, or deaths among the 12 patients. Five patients experienced 5 minor postoperative complications that consisted of cast- or orthosis-related skin breakdown remote from the incision (n = 3), incidental surgical site hematoma that required no surveillance or intervention (n = 1), and contact dermatitis attributed to the surgical dressing that resolved with topical corticosteroids (n = 1). Conclusions: With an appropriate multidisciplinary approach, there is minimal risk for developing perioperative and 30-day postoperative adverse events for adults undergoing SEMLS to correct upper extremity deformities secondary to UMN syndrome. Level of Evidence: IV

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