scholarly journals Silence of Stomatin-Like Protein 2 Represses Migration and Invasion Ability of Human Liver Cancer Cells via Inhibiting the Nuclear Factor Kappa B (NF-κB) Pathway

2018 ◽  
Vol 24 ◽  
pp. 7625-7632
Author(s):  
Wenyu Zhu ◽  
Wei Li ◽  
Qian Geng ◽  
Xiaoying Wang ◽  
Wei Sun ◽  
...  
2012 ◽  
Vol 40 (03) ◽  
pp. 643-656 ◽  
Author(s):  
Seung-Hum Kim ◽  
Chung-Yueh Huang ◽  
Cheng-Yu Tsai ◽  
Shu-Yi Lu ◽  
Chien-Chih Chiu ◽  
...  

The mechanism of action of Prunella vulgaris L. (PV) affecting cell migration and invasion of human liver cancer cells remains unknown. In this work we showed that the aqueous extract of PV affected migration and invasion of human liver carcinoma cells by inhibiting activities of metalloproteases, MMP-2 and MMP-9, without affecting cell viabilities. We further showed that PV suppressed migration through attenuation of enzymatic activities of MMP-9 and MMP-2 at transcriptional levels and the effects can be correlated with the status of p53 in hepatocarcinoma cells. This work provides a new dimension of understanding on Prunella vulgaris in restraining migration and invasion in human liver cancer cells.


2021 ◽  
Author(s):  
Novi Angeline ◽  
Sung-Sik Choo ◽  
Cheol-Hwi Kim ◽  
Suk Ho Bhang ◽  
Tae-Hyung Kim

2014 ◽  
Vol 9 (3) ◽  
pp. 904-910 ◽  
Author(s):  
GAOFENG LIANG ◽  
GUANGDA LI ◽  
YANYAN WANG ◽  
WANJUN LEI ◽  
ZHONGDANG XIAO

Hepatology ◽  
2007 ◽  
Vol 47 (2) ◽  
pp. 521-531 ◽  
Author(s):  
Komal Ramani ◽  
Heping Yang ◽  
Meng Xia ◽  
Ainhoa Iglesias Ara ◽  
José M. Mato ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document