An evaluation of thyroid autoimmunity in patients with beta thalassemia minor: A case-control study

Abstract Background:FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of Ferritin on intact PTH, FGF23 and l,25(OH)2D3 in patients with major thalassemia. It evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the absence of proper PTH function in human. Methods:In this case-control study,25 patients with major-beta thalassemia with hypoparathyroidism and their age- and gender-matched patients with major-beta thalassemia having normal parathyroid function were enrolled. Biochemical studies assessed serum calcium, albumin phosphorus, alkaline phosphatase, PTH, FGF23, 25(OH)D, 1,25(OH)2D3, Ferritin and Fractional excretion of phosphorous. Results:FGF23 was higher in the patients with hypoparathyroidism compared to controls(p=0.002). Fractional excretion of phosphorous was lower in patients with hypoparathyroidism, despite of high FGF23(p=0.001). There was a correlation between serum1,25(OH)2D3 and FGF23 with ferritin in the controls(P=<0.001and P=<0.001,respectively). Conclusions: The present study suggested that rise in FGF23 in patients with thalassemia, may be due to either stimulating effect of PTH and 1,25(OH)2D3 on FGF23 production, or might be direct stimulating effect of ferritin. It seems that in hypoparathyroid patients with insufficient PTH action, the FGF23 is not able to exert its full function in reducing serum phosphorus level by its phosphaturic action.

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Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study

Sao Paulo Medical Journal ◽

10.1590/s1516-31802012000500005 ◽

2012 ◽

Vol 130 (5) ◽

pp. 294-298 ◽

Cited By ~ 6

Author(s):

Ruy Felippe Brito Gonçalves Missaka ◽

Henrique Costa Penatti ◽

Maria Regina Cavariani Silvares ◽

Célia Regina Nogueira ◽

Gláucia Maria Ferreira da Silva Mazeto

Keyword(s):

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Case Control Study ◽

Thyroid Autoimmunity ◽

Case Control ◽

Chronic Idiopathic Urticaria ◽

Public Institution ◽

Autoimmune Thyroid ◽

Allergic Condition ◽

Control Study

CONTEXT AND OBJECTIVE: An association between chronic idiopathic urticaria (CIU) and autoimmune thyroid disease (ATD) has been reported. However, there have not been any reports on whether ATD raises the risk of angioedema, which is a more severe clinical presentation of CIU. Thus, the aim of the present study was to evaluate whether the risk of angioedema is increased in patients with CIU and ATD. DESIGN AND SETTING: Case-control study including 115 patients with CIU at a tertiary public institution. METHODS: The patients were evaluated with regard to occurrence of angioedema and presence of ATD, hypothyroidism or hyperthyroidism. RESULTS: Angioedema was detected in 70 patients (60.9%). There were 22 cases (19.1%) of ATD, 19 (16.5%) of hypothyroidism and nine (7.8%) of hyperthyroidism. The risk among patients with ATD was 16.2 times greater than among those without this thyroid abnormality (confidence interval, CI = 2.07-126.86). The odds ratio for hypothyroidism was 4.6 (CI = 1.00-21.54) and, for hyperthyroidism, 3.3 (CI = 0.38-28.36). CONCLUSIONS: Patients with CIU and ATD presented greater risk of angioedema, which reinforces the idea that a relationship exists between this allergic condition and thyroid autoimmunity. This finding could imply that such patients require specifically directed therapy.

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Impact of beta thalassemia on maxillary sinuses and sino-nasal passages: A case control study

International Journal of Pediatric Otorhinolaryngology ◽

10.1016/j.ijporl.2015.10.016 ◽

2015 ◽

Vol 79 (12) ◽

pp. 2253-2259 ◽

Cited By ~ 3

Author(s):

Ahmed Ragab ◽

Seham Mohammed Ragab ◽

Mohammed Shawki

Keyword(s):

Case Control Study ◽

Case Control ◽

Beta Thalassemia ◽

Nasal Passages ◽

Control Study ◽

Maxillary Sinuses

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Detection of Thyroid Autoimmunity Markers in Euthyroid Women With Polycystic Ovary Syndrome: A Case-Control Study From Syria

International Journal of Endocrinology and Metabolism ◽

10.5812/ijem.17954 ◽

2014 ◽

Vol 12 (3) ◽

Cited By ~ 9

Author(s):

Raghad Al-Saab ◽

Shaden Haddad

Keyword(s):

Polycystic Ovary Syndrome ◽

Case Control Study ◽

Polycystic Ovary ◽

Thyroid Autoimmunity ◽

Case Control ◽

Ovary Syndrome ◽

Control Study

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Faculty Opinions recommendation of Association of Melasma with Thyroid Autoimmunity: A Case-Control Study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718508608.793497788 ◽

2014 ◽

Author(s):

Vangee Handog ◽

Maria Juliet Macarayo

Keyword(s):

Case Control Study ◽

Thyroid Autoimmunity ◽

Case Control ◽

Control Study

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Frequency and determinants of thyroid autoimmunity in Ghanaian type 2 diabetes patients: a case-control study

Pan African Medical Journal Conference Proceedings ◽

10.11604/pamj.cp.2017.2.7.20 ◽

2018 ◽

Vol 1 ◽

Author(s):

Osei Sarfo-Kantanka ◽

Fred Stephen Sarfo ◽

Eunice Oparebea Ansah ◽

Ernest Yorke ◽

Josephine Akpalu ◽

...

Keyword(s):

Type 2 Diabetes ◽

Case Control Study ◽

Thyroid Autoimmunity ◽

Case Control ◽

Control Study ◽

Diabetes Patients

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Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study

BMC Nephrology ◽

10.1186/s12882-020-02101-3 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Forough Saki ◽

Azita Salehifar ◽

Seyed Reza Kassaee ◽

Gholamhossein Ranjbar Omrani

Keyword(s):

Serum Ferritin ◽

Case Control Study ◽

Fractional Excretion ◽

Case Control ◽

Beta Thalassemia ◽

Strong Positive Correlation ◽

Parathyroid Function ◽

And Gender ◽

High Level ◽

Control Study

Abstract Background FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)2D3 in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the absence of proper PTH functioning in human. Methods In this case-control study, 25 major-beta thalassemia patients with hypoparathyroidism were age- and gender-matched with major-beta thalassemia patients having normal parathyroid function. Biochemical studies assessed the serum calcium, albumin, phosphorus, alkaline phosphatase, PTH, FGF23, 25(OH) D, 1,25(OH)2D3, ferritin, and the fractional excretion of phosphorous. Results FGF23 was higher in the patients with hypoparathyroidism than the controls (P = 0.002). The fractional excretion of phosphorous was lower in patients with hypoparathyroidism, despite the high level of FGF23 (P = 0.001). There was a correlation between serum 1,25(OH)2D3 and FGF23 with ferritin in the controls (P = < 0.001and P = < 0.001, respectively). Conclusions The present study showed a strong positive correlation between serum ferritin and levels of FGF23 and 1,25(OH)2D3. We hypothesized that ferritin could have a stimulatory effect on the production of 1,25(OH)2D3. Moreover, a rise in FGF23 in patients with thalassemia, might be either associated with the stimulating effect of PTH and 1,25(OH)2D3, or directly related to the stimulating effect of ferritin.

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