Impact of beta thalassemia on maxillary sinuses and sino-nasal passages: A case control study

2015 ◽  
Vol 79 (12) ◽  
pp. 2253-2259 ◽  
Author(s):  
Ahmed Ragab ◽  
Seham Mohammed Ragab ◽  
Mohammed Shawki
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Beta Thalassemia ◽  
Nasal Passages ◽  
Control Study ◽  
Maxillary Sinuses

scholarly journals Association of vitamin D and FGF23 with serum Ferritin in hypoparathyroid thalassemia, a case control study

2019 ◽  
Author(s):  
Forough Saki ◽  
azita salehifar ◽  
Seyed Reza Kassaee ◽  
Gholamhossein Ranjbar omrani
Keyword(s):  
Case Control Study ◽  
Fractional Excretion ◽  
Case Control ◽  
Beta Thalassemia ◽  
Phosphate Homeostasis ◽  
Intact Pth ◽  
Age And Gender ◽  
Parathyroid Function ◽  
And Gender ◽  
Control Study

Abstract Background:FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of Ferritin on intact PTH, FGF23 and l,25(OH)2D3 in patients with major thalassemia. It evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the absence of proper PTH function in human. Methods:In this case-control study,25 patients with major-beta thalassemia with hypoparathyroidism and their age- and gender-matched patients with major-beta thalassemia having normal parathyroid function were enrolled. Biochemical studies assessed serum calcium, albumin phosphorus, alkaline phosphatase, PTH, FGF23, 25(OH)D, 1,25(OH)2D3, Ferritin and Fractional excretion of phosphorous. Results:FGF23 was higher in the patients with hypoparathyroidism compared to controls(p=0.002). Fractional excretion of phosphorous was lower in patients with hypoparathyroidism, despite of high FGF23(p=0.001). There was a correlation between serum1,25(OH)2D3 and FGF23 with ferritin in the controls(P=<0.001and P=<0.001,respectively). Conclusions: The present study suggested that rise in FGF23 in patients with thalassemia, may be due to either stimulating effect of PTH and 1,25(OH)2D3 on FGF23 production, or might be direct stimulating effect of ferritin. It seems that in hypoparathyroid patients with insufficient PTH action, the FGF23 is not able to exert its full function in reducing serum phosphorus level by its phosphaturic action.

scholarly journals Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Forough Saki ◽  
Azita Salehifar ◽  
Seyed Reza Kassaee ◽  
Gholamhossein Ranjbar Omrani
Keyword(s):  
Serum Ferritin ◽  
Case Control Study ◽  
Fractional Excretion ◽  
Case Control ◽  
Beta Thalassemia ◽  
Strong Positive Correlation ◽  
Parathyroid Function ◽  
And Gender ◽  
High Level ◽  
Control Study

Abstract Background FGF23 controls serum l,25(OH)2D3 levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)2D3 in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the absence of proper PTH functioning in human. Methods In this case-control study, 25 major-beta thalassemia patients with hypoparathyroidism were age- and gender-matched with major-beta thalassemia patients having normal parathyroid function. Biochemical studies assessed the serum calcium, albumin, phosphorus, alkaline phosphatase, PTH, FGF23, 25(OH) D, 1,25(OH)2D3, ferritin, and the fractional excretion of phosphorous. Results FGF23 was higher in the patients with hypoparathyroidism than the controls (P = 0.002). The fractional excretion of phosphorous was lower in patients with hypoparathyroidism, despite the high level of FGF23 (P = 0.001). There was a correlation between serum 1,25(OH)2D3 and FGF23 with ferritin in the controls (P = < 0.001and P = < 0.001, respectively). Conclusions The present study showed a strong positive correlation between serum ferritin and levels of FGF23 and 1,25(OH)2D3. We hypothesized that ferritin could have a stimulatory effect on the production of 1,25(OH)2D3. Moreover, a rise in FGF23 in patients with thalassemia, might be either associated with the stimulating effect of PTH and 1,25(OH)2D3, or directly related to the stimulating effect of ferritin.

Headache in beta-thalassemia: An Italian multicenter clinical, conventional MRI and MR-angiography case-control study

2020 ◽  
Vol 81 ◽  
pp. 102403 ◽  
Author(s):  
Immacolata Tartaglione ◽  
Martina Caiazza ◽  
Rosanna Di Concilio ◽  
Angela Ciancio ◽  
Elisa De Michele ◽  
...  
Keyword(s):  
Mr Angiography ◽  
Case Control Study ◽  
Case Control ◽  
Beta Thalassemia ◽  
Conventional Mri ◽  
Control Study

scholarly journals ASSOCIATION OF THALASSEMIA MAJOR WITH CONSANGUINEOUS MARRIAGES IN THE PROVINCE OF KHYBER PAKHTUNKHWA- A CASE CONTROL STUDY

1969 ◽  
Vol 4 (1) ◽  
pp. 442-445
Author(s):  
HAYAT MUHAMMAD KHAN ◽  
ZIA UR REHMAN ◽  
MOHAMMAD AMJAD ◽  
NAEEMULLAH ◽  
MUHAMMAD NAEEM
Keyword(s):  
Case Control Study ◽  
Genetic Disorder ◽  
Thalassemia Major ◽  
Case Control ◽  
Beta Thalassemia ◽  
P Value ◽  
Literacy Rate ◽  
Consanguineous Marriages ◽  
Thalassemia Trait ◽  
Control Study

BACKGROUND: Beta Thalassemia is the commonest genetic disorder worldwide. It is one of thetypes of hemoglobinopathies which results from either deficient synthesis or complete loss of one of theBeta chains of hemoglobin. Children with Thalassemia major or minor might have defective genes intheir parents. Consanguineous marriages are important risk factors in transmission of thalassemia fromparents to their children. So avoidance of cousin marriages can prevent thalassemia in children.Premarital counseling with couples having thalassemia trait can be an important step in prevention ofthalassemia. Pre-marriage chromosomal studies can be useful in prevention of thalassemia.OBJECTIVE: The main objective of the study is to establish an association of cousin marriages withthalassemia major in the Pathan community of Khyber Pakhtunkhwa.CONCLUSION: Thalassemia is the commonest genetic disorder in the world. It is more prevalent inthose families where cousin marriages are frequent. The same is situation in the province of KPK whereprevalence of cousin marriages is more than 55 %.RESULTS: Total 180 cases and controls were analyzed with 1:1 ratio. Out of the total 109 (60%) weremale children while 71 (40%) were female children. Father literacy rate was 54% and mother literacyrate was 18%. 66% parents of the cases were knowledgeable about the disease. Association of cousinmarriages with thalassemia major was significant with an odds ratio of 2.25 (Cl 95%, P value 0.05).Rest of the variables had no significant association with thalassemia major.Key words: Thalassemia, Consanguineous Marriages

scholarly journals DERMATOGLYPHIC STUDY OF BETA THALASSEMIA IN A TERTIARY CARE HOSPITAL – A CASE CONTROL STUDY

2020 ◽  
pp. 58-61
Author(s):  
Oindrila Chhatui ◽  
Pranab Mukherjee ◽  
Premananda Bharati ◽  
Debarshi Jana
Keyword(s):  
Case Control Study ◽  
Genetic Disorder ◽  
Tertiary Care ◽  
Case Control ◽  
Beta Thalassemia ◽  
Control Group ◽  
Care Hospital ◽  
Control Groups ◽  
Control Male ◽  
Control Study

BACKGROUND: The term “thalassemia” was coined by Whipple and Bradford in 1932, in their classical paper of pathology of the condition. Thalassemia is a heterogenous group of genetic disorder affecting haemoglobin synthesis which results from a reduced rate of production of one or more globin chains of haemoglobin. AIM: The current study will try to find out the dermatoglyphic correlation between thalassemic children and children not having thalassemia in respect of gender as well as bilateral asymmetry. METHODS: The sample for the present case control study was collected from Thalassemia unit, under Paediatric department at R.G. Kar Medical College and Hospital, Kolkata. Among 204 individuals- 102 are cases, who are diagnosed Beta Thalassemia patients up to 12 yrs of age and 102 are normal children upto 12yrs of age taken as control groups. Among 102 in each case and control groups, 51 are male and 51 are female individuals. RESULT: Association of control male and Beta thalassemic male vs. Triradial count right was statistically significant (p<0.0001). Association of control male and Beta thalassemic male vs. Triradial count left was statistically significant (p<0.0001). CONCLUSION: In female thalassemia patients, there was complete absence of radial loops. But, significant lower incidence of radial loops of left hand was observed in male Beta thalassemics than the control group.

scholarly journals Association of vitamin D and FGF23 with serum Ferritin in hypoparathyroid thalassemia: A case control study

2019 ◽  
Author(s):  
Forough Saki ◽  
Azita Salehifar ◽  
Seyed Reza Kassaee ◽  
gholamhossein Ranjbar omrani
Keyword(s):  
Serum Ferritin ◽  
Case Control Study ◽  
Fractional Excretion ◽  
Case Control ◽  
Beta Thalassemia ◽  
Strong Positive Correlation ◽  
Parathyroid Function ◽  
And Gender ◽  
High Level ◽  
Control Study

Abstract Background FGF23 controls serum l,25(OH) 2 D 3 levels and phosphate homeostasis. This study evaluates the effects of Ferritin on intact PTH, FGF23 and l,25(OH) 2 D 3 in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the absence of proper PTH function in human.Methods In this case-control study, 25 patients with major-beta thalassemia with hypoparathyroidism and their age- and gender-matched patients with major-beta thalassemia having normal parathyroid function were enrolled. Biochemical studies assessed the serum calcium, albumin phosphorus, alkaline phosphatase, PTH, FGF23, 25(OH)D, 1,25(OH)2D3, Ferritin and Fractional excretion of phosphorous.Results FGF23 was higher in the patients with hypoparathyroidism compared to the controls (p=0.002). Fractional excretion of phosphorous was lower in patients with hypoparathyroidism, despite the high level of FGF23(p=0.001). There was a correlation between serum1, 25(OH)2D3, and FGF23 with ferritin in the controls ( P =<0.001and P =<0.001, respectively).Conclusions The present study showed a strong positive correlation between serum ferritin and FGF23 and 1,25(OH)2D3. We hypothesized that ferritin could have stimulatory effect on production of 1,25(OH)2D3. Also, rise in FGF23 in patients with thalassemia, might be associated with either stimulating effect of PTH and 1,25(OH)2D3, or might be related to direct stimulating effect of ferritin.

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