scholarly journals Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer

2019 ◽  
Vol 35 (5) ◽  
Author(s):  
Sumei Zhang ◽  
Shufen Zhao ◽  
Xinzhen Fu
Keyword(s):  
Prostate Cancer ◽  
Prostatic Cancer ◽  
Advanced Prostate Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Control Group ◽  
Observation Group ◽  
Short Term ◽  
Advanced Prostatic Cancer ◽  
Intensity Modulated ◽  
Significant Difference

Objective: To evaluate the clinical efficacy of intensity modulated radiation therapy and endocrinotherapy for middle and advanced prostate cancer. Methods: Total 104 elderly patients with middle and advanced prostate cancer who were admitted to our hospital from November 2014 to August 2015 were selected using random number table method. They were divided into intensity-modulated radiotherapy combined with endocrinotherapy group (observation group) and conventional radiotherapy combined with endocrinotherapy group (control group), 52 each. The serum levels of prostate specific antigen (PSA) and free prostate antigen (f PSA) were measured three months after treatment. The short-term efficacy and toxic and side effects of the patients were observed, and the survival rate was recorded through three-year follow up. Results: The clinical effective rate of the observation group was 92.68%, and that of the control group was 70.73%; there was a significant difference between the two groups (P<0.05). The serum PSA and f PSA levels of the two groups were similar before treatment, but there was no significant difference (P>0.05). The serum PSA and f PSA levels after treatment were significantly lower than before treatment. The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05). The one-year and three-year survival rates of the two groups were significantly different (90.0 vs. 80.0%, 60.0 vs. 43.3%, P>0.05). Conclusion: Intensity modulated radiotherapy combined with endocrinotherapy was safe and well tolerated in the treatment of middle and advanced prostate cancer. It can improve the short-term efficacy and effectively reduce the serum oncological index concentration of patients. It can be promoted in clinics. doi: https://doi.org/10.12669/pjms.35.5.591 How to cite this:Zhang S, Zhao S, Fu X. Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.591 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Short-term efficacy comparison between helical tomotherapy and intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma

2020 ◽  
Author(s):  
Zhen Cui ◽  
Jia Liu ◽  
Qiaoyu Sun ◽  
Chaoge Wang ◽  
Meifang Fang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Planning Target Volume ◽  
Helical Tomotherapy ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Target Volume ◽  
Short Term ◽  
Intensity Modulated ◽  
Significant Difference ◽  
Better Than

Abstract Background: To evaluate short-term safety and efficacy of helical tomotherapy (HT) versus intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC).Methods: Retrospective analysis of locally advanced nasopharyngeal carcinoma treated with radiotherapy and concurrent platinum based neoadjuvant chemotherapy (cisplatin 80 mg/m2 every 3 weeks for 1 cycle) in our hospital from February 2017 to October 2019, including 70 patients in HT group and 70 in IMRT group. The target area of ​​the tumor was delineated by magnetic resonance (MRI) imaging. The prescription doses delivered to the gross tumor volume (pGTVnx) and positive lymph nodes (pGTVnd), the high risk planning target volume (PTV1), and the low risk planning target volume (PTV2), were 69.96 Gy, 66-70 Gy, 60 Gy and 50-54 Gy, in 33 fractions, respectively. Acute reactions were evaluated according to the RTOG/EORTC criteria, whereas the therapeutic efficacy was assessed according to RECTST version 1.1 criteria in a 3-months period.Results: The CI of PGTVnx, PGTVnd, PTV1 and PTV2, and HI of PGTVnx, PTV1 and PTV2 in HT group was significantly better than those in IMRT group. The OAR Dmax and Dmean in HT group were better than those in IMRT group with a significant difference (all p <0.05). Patients in the HT group were significantly better than those in the IMRT group in the protection of acute parotid gland injury and hearing damage (p <0.05), but not other acute adverse reaction. No significant difference was found on the short-term efficacy illustrated by ORR between HT group and IMRT group (x2 = 0.119; p = 0.730).Conclusions: Compared with IMRT, HT has better radiophysical-related dosimetric advantages in radiotherapy for locally advanced nasopharyngeal carcinoma. Despite similar on short-term effects, HT has lower incidence of adverse reactions than IMRT.

scholarly journals Efficacy of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Management of Malignant Ascites

2020 ◽  
Author(s):  
Jie Jiao ◽  
Chengzhen Li ◽  
Guanying Yu ◽  
Lei Zhang ◽  
Xiaoyan Shi ◽  
...  
Keyword(s):  
Intraperitoneal Chemotherapy ◽  
Adverse Reactions ◽  
Total Effective Rate ◽  
Malignant Ascites ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Short Term ◽  
Significant Difference ◽  
The Difference

Abstract Objective: The purpose of this study is to compare the difference of clinical efficacy between conventional intraperitoneal chemotherapy and HIPEC, so as to explore the clinical application value and advantages of HIPEC.Design: A retrospective analysis was conducted on 80 patients with malignant ascites admitted to our hospital from June 2017 to June 2019. The general clinical data and qualitative data of the treatment results of 80 patients with malignant ascites were processed by SPSS19.0 using χ2 test and quantitative data were processed by t test. P <0.05, statistical data can be considered statistically significant.Results: 1. There was no significant change in vital signs and temperature in the observation group during the treatment, and the difference was not statistically significant 2. The short-term total effective rate of patients in the observation group was 91.11%, and the short-term total effective rate of the patients in the control group was 40%.3. There was no significant difference in the incidence of adverse reactions between the two groups of patients.Conclusion: Intraperitoneal hyperthermic chemotherapy combined with intravenous chemotherapy can significantly control malignant ascites, and has small adverse reactions, which is worthy of clinical promotion and application.

Comparison of conformal radiotherapy, intensity-modulated radiotherapy and tomotherapy irradiation techniques in prostate cancers

2019 ◽  
Vol 18 (03) ◽  
pp. 276-279
Author(s):  
Taylan Tuğrul ◽  
Nezahat Olacak ◽  
Murat Köylü
Keyword(s):  
Prostate Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Conformal Radiotherapy ◽  
Tumour Volume ◽  
Healthy Tissue ◽  
Organ Doses ◽  
Dose Volume Histograms ◽  
Intensity Modulated ◽  
Significant Difference ◽  
3D Crt

AbstractAimThe aim of this study is to compare three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT) and tomotherapy techniques used in the treatment of prostate cancer with target and critical organ doses to be included.Materials and MethodsThe target dose was studied with 4-and 6-field 3D-CRT, 7-field IMRT and tomotherapy techniques used to treat ten patients for prostate cancer and the dose volume histograms of critical organs were analyzed. The same target volumes, critical organs doses prescribed and treatment times for the three techniques were compared. Total dose of 76 Gy was given using 6 MV and 18 MV for 3D-CRT, 6 MV for IMRT and tomotherapy techniques.ResultsWhen we compare the three techniques, for rectum V35(p:0·001), V65(p:0·001), D50(p:0·020) and D25(p:0·002), for bladder V50(p:0·027), V65(p:0·006), V100(p:0·006) and for femoral head, the V50(p:0·001) dose was found to be significantly different and more favourable in the tomotherapy technique. Significant differences were found with IMRT planning in 50% of bladder volume (p:0·002). There is no significant difference between the three techniques for doses of 100% volume of rectum and 25% of volume of bladder. The minimum dose that healthy tissue received which was outside the tumour volume was investigated.FindingsDoses to critical organs were lower using the tomotherapy technique. However, the minimum doses that healthy tissue received were higher for the tomotherapy technique. When the beam on times were compared for all three techniques, a significant difference was found in favor of tomotherapy.

scholarly journals Variations in inter-observer contouring and its impact on dosimetric and radiobiological parameters for intensity-modulated radiotherapy planning in treatment of localised prostate cancer

2008 ◽  
Vol 7 (2) ◽  
pp. 77-88 ◽  
Author(s):  
Anup Kumar Bhardwaj ◽  
T.S. Kehwar ◽  
S.K. Chakarvarti ◽  
Goda Jayant Sastri ◽  
A.S. Oinam ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Tumour Volume ◽  
Normal Tissue Complication Probability ◽  
Radiotherapy Planning ◽  
Conformity Index ◽  
Tumour Control ◽  
Intensity Modulated ◽  
Tumour Control Probability ◽  
Significant Difference

AbstractInter-observer variations in contouring and their impacts on dosimetric and radiobiological parameters in intensity-modulated radiotherapy (IMRT) treatment for localised prostate cancer patients were investigated. Four observers delineated the gross tumour volume (GTV) (prostate and seminal vesicles), bladder and rectum for nine patients. Contouring done by radiologist was considered as gold standard for comparison purposes and for IMRT plan optimisation. Maximum average variations in contoured prostate, bladder and rectum volumes were 3% (SD = 8.4), 2.5% (SD = 4.12) and 13.2% (SD = 6.77), respectively. The average conformity index for standard contouring set (observer A) was 0.85 (SD = 0.028) and statistically significant differences were observed for observers A–B (p = 0.008), A–C (p = 0.006) and A–D (p = 0.011). Average values of normal tissue complication probability for bladder and rectum for observer A were 0.361% (SD = 0.036) and 1.59% (SD = 0.14). Maximum average tumour control probability was 99.94% (SD = 0.035) and statistically significant difference was observed for observers A–B (p = 0.037) and observers A–C (p = 0.01). Inter-observer contouring variations have significant impact on dosimetric and radiobiological outcome in IMRT treatment planning. So accurate contouring of tumour and normal organs is a fundamental prerequisite to make good correlation between calculated and clinical observed results.

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