Changes in esterase activity in the spinning gland cells of Diacrisia obliqua (lepidoptera) during sequential stages of development.

SummaryThe preparation of thrombin-coagulase is described. The properties of thrombin-coagulase are compared with those of biothrombin: kinetics, thermostability, adsorption, chromatography, esterase activity, clotting activity, action on platelets and on factors V and VIII, susceptibility to inhibitors.Biothrombin and thrombin-coagulase are closely related but distinct. Both apparently derive from prothrombin. Prothrombin and coagulase combine to form a complex: thrombin-coagulase wherein both factors are necessary for its activity. Possible explanations for the difference between thrombin-coagulase and biothrombin are proposed.

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Activity of Plasmin and Streptokinase-Activator on Substituted Arginine and Lysine Esters

Thrombosis and Haemostasis ◽

10.1055/s-0038-1655623 ◽

1966 ◽

Vol 16 (01/02) ◽

pp. 018-031 ◽

Cited By ~ 13

Author(s):

S Sherry ◽

Norma Alkjaersig ◽

A. P Fletcher

Keyword(s):

Molecular Structure ◽

Methyl Ester ◽

Comparative Studies ◽

Esterase Activity ◽

Methyl Esters ◽

Hydrolytic Activity ◽

The Other ◽

Other Hand

SummaryComparative studies have been made of the esterase activity of plasmin and the streptokinase-activator of plasminogen on a variety of substituted arginine and lysine esters. Human plasmin preparations derived by different methods of activation (spontaneous in glycerol, trypsin, streptokinase (SK) and urokinase) are similar in their esterase activity; this suggests that the molecular structure required for such esterase activity is similar for all of these human plasmins. Bovine plasmin, on the other hand, differs from human plasmin in its activity on several of the substrates studied (e.g., the methyl esters of benzoyl arginine and tosyl, acetyl and carbobenzoxy lysine), a finding which supports the view that molecular differences exist between the two animal plasmins. The streptokinase-activator hydrolyzes both arginine and lysine esters but the ratios of hydrolytic activity are distinct from those of plasmin and of other activators of plasminogen. The use of benzoyl arginine methyl ester as a substrate for the measurement of the esterase activity of the streptokinase-activator is described.

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Autómatas Celulares Aplicados al Comportamiento de Células de Cáncer Cervicouterino

Tecnología Educativa Revista CONAIC ◽

10.32671/terc.v6i1.78 ◽

2019 ◽

Vol 6 (1) ◽

pp. 44-49

Author(s):

Tania Muñoz Jiménez ◽

Aurora Torres Soto ◽

María Dolores Torres Soto

Keyword(s):

Cellular Automaton ◽

Medical Model ◽

Research Process ◽

Simulation Algorithm ◽

Stages Of Development ◽

Literary Research ◽

Migration Dynamics ◽

Three Stages ◽

And Migration ◽

Best Parameters

En este documento se describe el desarrollo e implementación de un modelo para simular computacionalmente la dinámica del crecimiento y migración del cáncer cervicouterino, considerando sus principales características: proliferación, migración y necrosis, así como sus etapas de desarrollo. El modelo se desarrolló mediante un autómata celular con enfoques paralelo y secuencial. El autómata celular se basó en el modelo de Gompertz para simular las etapas de desarrollo de este cáncer, el cual se dividió en tres etapas cada una con diferentes comportamientos durante la simulación. Se realizó un diseño experimental con parámetros de entrada que se seleccionaron a partir de la investigación literaria y su discusión con médicos expertos. Al final del proceso de investigación, se logró obtener un algoritmo computacional de simulación muy bueno comparado con el modelo médico de Gompertz y se encontraron los mejores parámetros para su ejecución mediante un diseño factorial soportado estadísticamente. This paper describes the development and implementation of a model to computationally simulate the growth and migration dynamics of cervical cancer, considering its main characteristics: proliferation, migration and necrosis, as well as its stages of development. The model was developed by means of a cellular automaton with parallel and sequential approaches. The cellular automaton was based on the model of Gompertz to simulate the stages of development of this cancer, which was divided into three stages, each with different behaviors during the simulation. An experimental design was carried out with input parameters that were selected from literary research and its discussion with expert physicians. At the end of the research process, a very good simulation algorithm was obtained compared to the Gompertz medical model and the best parameters for its execution were found by means of a statistically supported factorial design.

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