scholarly journals Cytomegalovirus in pregnancy and the neonate

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 138 ◽  
Author(s):  
Vincent C. Emery ◽  
Tiziana Lazzarotto
Keyword(s):  
Vaccine Development ◽  
Cmv Infection ◽  
Chain Reaction ◽  
Congenital Cytomegalovirus ◽  
Symptomatic Disease ◽  
Diagnosis And Prognosis ◽  
Viral Therapy ◽  
Avidity Test ◽  
Polymerase Chain ◽  
Anti Viral Therapy

Congenital cytomegalovirus (CMV) remains a leading cause of disability in children. Understanding the pathogenesis of infection from the mother via the placenta to the neonate is crucial if we are to produce new interventions and provide supportive mechanisms to improve the outcome of congenitally infected children. In recent years, some major goals have been achieved, including the diagnosis of primary maternal CMV infection in pregnant women by using the anti-CMV IgG avidity test and the diagnosis and prognosis of foetal CMV infection by using polymerase chain reaction real-time tests to detect and quantify the virus in amniotic fluid. This review summarises recent advances in our understanding and highlights where challenges remain, especially in vaccine development and anti-viral therapy of the pregnant woman and the neonate. Currently, no therapeutic options during pregnancy are available except those undergoing clinical trials, whereas valganciclovir treatment is recommended for congenitally infected neonates with moderately to severely symptomatic disease.

Clinical profile of symptomatic congenital cytomegalovirus infection: cases from a tertiary hospital in north India

2020 ◽  
Vol 50 (3) ◽  
pp. 282-284
Author(s):  
Deepanjan Bhattacharya ◽  
Inusha Panigrahi ◽  
Chakshu Chaudhry
Keyword(s):  
Intracranial Haemorrhage ◽  
Tertiary Hospital ◽  
North India ◽  
Common Finding ◽  
Cmv Infection ◽  
Chain Reaction ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
The Mean ◽  
Polymerase Chain

We retrospectively analysed the records of nine infants with polymerase chain reaction proven congenital cytomegalovirus (CMV) infection, of which 66% were born preterm. Microcephaly was a universal finding, followed by hepatosplenomegaly in 89%, while chorioretinitis was seen in only 44% cases. The mean age at diagnosis was 3.5 months. Neuroimaging was abnormal in 78%, with ventriculomegaly being the most common finding followed by T2/FLAIR white matter abnormalities, periventricular cysts and intracranial haemorrhage.

scholarly journals Congenital Cytomegalovirus Infection Masquerading as Antenatal Ventriculomegaly With Intraventricular Hemorrhage in a Term Neonate

2019 ◽  
Vol 10 (1) ◽  
pp. 55-57
Author(s):  
Deepanjan Bhattacharya ◽  
B. N. Anil Kumar ◽  
Inusha Panigrahi ◽  
Anupriya Kaur
Keyword(s):  
Intraventricular Hemorrhage ◽  
Term Neonate ◽  
Preterm Neonates ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Positive Polymerase Chain Reaction ◽  
Congenital Cytomegalovirus ◽  
Left Lateral Ventricle ◽  
Polymerase Chain ◽  
Occipital Horn

Intraventricular hemorrhage is an uncommon manifestation of congenital cytomegalovirus (CMV) infection and has been described in preterm neonates. We discuss a term neonate, who was referred because of intracranial hemorrhage and hydrocephalous detected in the antenatal ultrasound. She had cholestatic jaundice, hepatitis, and thrombocytopenia, with positive polymerase chain reaction for CMV. Neuroimaging revealed reduced sulcation, mildly enlarged ventricles, and multiple periventricular cysts, along with residual hemorrhage in occipital horn of left lateral ventricle. She was started on ganciclovir, following which there was improvement in platelet count, jaundice, as well as transaminase levels.

scholarly journals An Unusual Presentation of Cytomegalovirus Infection: Generalized Edema

2019 ◽  
Vol 29 (1) ◽  
pp. 94-96 ◽  
Author(s):  
Ceyda Tuna Kirsaclioglu ◽  
Gulin Hizal ◽  
Esra Karakus ◽  
Tulin Revide Sayli
Keyword(s):  
Cytomegalovirus Infection ◽  
Clinical Presentation ◽  
Gastrointestinal Symptoms ◽  
Related Protein ◽  
Cmv Infection ◽  
Protein Loss ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Gastrointestinal Protein Loss ◽  
Protein Losing Gastropathy

Objective: Cytomegalovirus (CMV) infection may rarely lead to protein-losing gastropathy that presents with nausea, vomiting, abdominal pain, and edema in immunocompetent children, but extremely rarely with only generalized edema. Clinical Presentation and Intervention: A previously healthy 5-year-old boy presented with generalized edema without any other symptoms. He had hypoalbuminemia but no proteinuria. He was evaluated for gastrointestinal protein loss, and hypertrophic gastropathy was revealed on esophagogastroduodenoscopy. Meanwhile, CMV infection was detected by serologic tests and polymerase chain reaction in the blood. He recovered spontaneously within a week. Conclusion: CMV-related protein-losing gastropathy may present with generalized edema without any gastrointestinal symptoms.

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