scholarly journals Prednisolone-induced diabetes mellitus without pancreatic islet pathology in a dog

2021 ◽  
Vol 22 (1) ◽  
pp. 63-69
Author(s):  
Taesik Yun ◽  
Hakhyun Kim ◽  
Yoonhoi Koo ◽  
Dongwoo Chang ◽  
Byeong-Teck Kang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Islet

Streptozocin-induced Pancreatic Islet Destruction in Beef Cows

2001 ◽  
Vol 38 (6) ◽  
pp. 715-720 ◽  
Author(s):  
H. L. Higdon ◽  
P. G. Parnell ◽  
J. E. Hill ◽  
J. C. Spitzer
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Islet ◽  
Marked Decrease ◽  
Tubulointerstitial Nephritis ◽  
Type I Diabetes ◽  
Beef Cows ◽  
Type I ◽  
Systemic Complications ◽  
Bovine Pancreas ◽  
Insulin Insufficiency

Streptozocin (STZ) induces diabetes mellitus in sheep and pigs. To test the effect of STZ in cattle, cows were given 75–150 mg STZ per kilogram of body weight. Cows receiving 150 mg/kg required euthanasia within 24 hours after infusion because of the severe systemic effects of STZ. Seven cows receiving doses of ≤100 mg/kg had mild to marked decrease in islet immunoreactivity for insulin and in pancreatic islet density and mild to severe tubulointerstitial nephritis. Two cows receiving 75 and 85 mg/kg STZ regained their ability to produce insulin and return blood glucose to basal levels. One cow given 100 mg/kg STZ developed insulin insufficiency consistent with type I diabetes mellitus. These findings demonstrate the susceptibility of the bovine pancreas to STZ; however, severe systemic complications were encountered. Alternative dosages and methodologies should be considered in future attempts to induce diabetes in cattle using STZ.

Diabetes mellitus-associated decrease in nerve growth factor levels is reversed by allogeneic pancreatic islet transplantation

1991 ◽  
Vol 125 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Rainer Hellweg ◽  
Manfred Wöhrle ◽  
Heinz-Dieter Hartung ◽  
Hilmar Stracke ◽  
Christoph Hock ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation ◽  
Nerve Growth

Intrasplenic xenografting of human fetal pancreatic islet cell cultures into rats with experimental diabetes mellitus

1983 ◽  
Vol 95 (5) ◽  
pp. 674-677 ◽  
Author(s):  
V. N. Blyumkin ◽  
N. N. Skaletskii ◽  
V. L. Popov ◽  
B. I. Shal'nev ◽  
M. A. Danilov
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Islet ◽  
Cell Cultures ◽  
Islet Cell ◽  
Experimental Diabetes ◽  
Experimental Diabetes Mellitus ◽  
Pancreatic Islet Cell

scholarly journals Gene Therapy to Improve Pancreatic Islet Transplantation for Type 1 Diabetes Mellitus

2010 ◽  
Vol 6 (5) ◽  
pp. 274-284 ◽  
Author(s):  
Amy Hughes ◽  
Claire Jessup ◽  
Chris Drogemuller ◽  
Daisy Mohanasundaram ◽  
Clyde Milner ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Therapy ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation

scholarly journals Effect of an oral α2-adrenergic blocker (MK-912) on pancreatic islet function in non-insulin-dependent diabetes mellitus

Metabolism ◽  
1991 ◽  
Vol 40 (11) ◽  
pp. 1160-1167 ◽  
Author(s):  
F.Javier Ortiz-Alonso ◽  
William H. Herman ◽  
Barry J. Gertz ◽  
Vanessa C. Williams ◽  
Marla J. Smith ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Islet ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Islet Function ◽  
Adrenergic Blocker ◽  
Insulin Dependent
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