Role of Oxidized Low-Density Lipoprotein in Hepatitis C Related Chronic Liver Disease

2017 ◽  
Vol 47 (3) ◽  
pp. 653-662
Author(s):  
Mahmoud Abu El-Makarem ◽  
Abdel-Aziz Abdel-Rahman El-Nokaly ◽  
Sayed Farouk Mohamed
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Chronic Liver ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals Role of lipid profile in assessment of severity of cirrhosis

2019 ◽  
Vol 6 (4) ◽  
pp. 1303
Author(s):  
Mahendrapal Singh ◽  
Mohd. Imran Khan ◽  
A. C. Gupta ◽  
Richa Giri ◽  
Ashfak Alam
Keyword(s):  
Liver Disease ◽  
Lipid Profile ◽  
Serum Cholesterol ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Chronic Liver ◽  
Serum Lipid Profile ◽  
Low Density

Background: Cirrhosis is defined anatomically as a diffuse process with fibrosis and nodule formation. It is the result of the fibrogenesis that occurs with chronic liver injury. For reduced liver biosynthesis capacity, low level of serum cholesterol, low density lipoprotein (LDL) and high density lipoprotein (HDL) is usually observed in the chronic liver disease. Due to the high prevalence of chronic liver disease in our country we have conducted this study to determine role of lipid profile in a patient with cirrhosis and to assess its relationship to the severity of cirrhosis.Methods: In this cross-sectional study, patients classified in 3 groups as per CTP classification for severity of cirrhosis. Serum lipid profile was observed in these patients. The primary aim was to assess changes in various parameters of lipid profile and its relationship with severity of liver cirrhosis.Results: About 74 cirrhotic patients were enrolled, 20 in class A, 25 in class B and 29 in class C. serum lipid profile was observed in these patients. Serum cholesterol and HDL cholesterol were decreased with increasing severity of cirrhosis. Serum triglyceride level increases with progression of cirrhosis and very low density lipoprotein (VLDL) level has no correlation with severity of cirrhosis.Conclusions: Serum cholesterol and HDL level decreases with progression of cirrhosis. In future serum lipid profile can be used in classification criteria for assessing severity of liver cirrhosis.

scholarly journals Oxidized Low-Density Lipoprotein Is a Novel Predictor of Interferon Responsiveness in Chronic Hepatitis C Infection

2015 ◽  
Vol 1 (3) ◽  
pp. 285-294.e1 ◽  
Author(s):  
Philipp Solbach ◽  
Sandra Westhaus ◽  
Maximilian Deest ◽  
Eva Herrmann ◽  
Thomas Berg ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Hepatitis C Infection

The role of oxidized low-density lipoprotein in atherogenesis

1993 ◽  
Vol 4 (5) ◽  
pp. 373-381 ◽  
Author(s):  
Judith A. Berliner ◽  
Margaret E. Haberland
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals The Role of Siglec-1 and SR-BI Interaction in the Phagocytosis of Oxidized Low Density Lipoprotein by Macrophages

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58831 ◽  
Author(s):  
Yi-song Xiong ◽  
Juan Yu ◽  
Chang Li ◽  
Lin Zhu ◽  
Li-juan Wu ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals Evaluation of the atherogenic role of lipoproteins and oxidized low-density lipoprotein in pre-eclampsia

2012 ◽  
Vol 2 (4) ◽  
pp. 142-146
Author(s):  
Yasser H. Shaaban ◽  
Fatma Aletebi ◽  
Manal Helal ◽  
Walid Saber
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals The protective role of high-density lipoprotein on oxidized-low-density-lipoprotein-induced U937/endothelial cell interactions

1994 ◽  
Vol 221 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Jeanette Anne Marie MAIER ◽  
Livia BARENGHI ◽  
Franco PAGANI ◽  
Silvia BRADAMANTE ◽  
Paola COMI ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Protective Role ◽  
High Density ◽  
Cell Interactions ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

The role of oxidized low density lipoprotein in the pathogenesis of atherosclerosis

1990 ◽  
Vol 11 (suppl E) ◽  
pp. 122-127 ◽  
Author(s):  
T. Kita ◽  
K. Ishii ◽  
M. Yokode ◽  
N. Kume ◽  
Y. Nagano ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

Protective role of intracellular glutathione against oxidized low density lipoprotein in cultured endothelial cells

1989 ◽  
Vol 163 (3) ◽  
pp. 1466-1472 ◽  
Author(s):  
Masafumi Kuzuya ◽  
Michitaka Naito ◽  
Chiaki Funaki ◽  
Toshio Hayashi ◽  
Kanichi Asai ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Protective Role ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Cultured Endothelial Cells ◽  
Intracellular Glutathione

scholarly journals Role of High-Density Lipoprotein Cholesterol (HDL-C) as a Clinical Predictor of Decompensation in Patients with Chronic Liver Disease (CLD)

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Harshavardhan Rao B ◽  
Priya Nair ◽  
Anoop K. Koshy ◽  
S. Krishnapriya ◽  
C. R. Greeshma ◽  
...  
Keyword(s):  
Liver Disease ◽  
High Density Lipoprotein ◽  
Chronic Liver Disease ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Chronic Liver ◽  
Lipoprotein Cholesterol

Introduction. Systemic inflammation triggered by bacterial products like lipopolysaccharides (LPS) in the circulation is an important factor leading to decompensation in patients with chronic liver disease (CLD). High-density lipoprotein cholesterol (HDL-C) has a significant role in innate immune response to LPS in the circulation and could therefore increase the risk for decompensation in patients with CLD. In this study, we have explored the role of HDL-C as a prognostic marker for decompensation. Methods. This was a prospective, observational, cohort study where consecutive patients with CLD were included. Patients with cholestatic liver disease and hepatocellular carcinoma were excluded. Fasting lipids were measured in all patients at the time of recruitment. Each patient was carefully followed up for development of decompensation events such as new-onset/worsening ascites, hepatic encephalopathy, or variceal bleed during follow-up. Results. A total of 170 patients were included (mean age 60 ± 11.5 years, M : F = 6 : 1 ). At the end of follow-up, 97/170 patients (57%) had decompensation events. Mean HDL-C levels were significantly lower among patients with decompensation ( 27.5 ± 15  mg/dL vs. 43.5 ± 13.9  mg/dL; p value 0.004). Using ROC analysis, cut-off for HDL-C of 36.4 mg/dL was identified. On multivariate analysis, HDL-C ( OR = 6.072 ; 95% CI 2.39-15.39) was found to have an independent association with risk of decompensation. Conclusions. HDL-C level (<36.4 mg/dL) is a reliable marker for risk of decompensation and can be a useful addition to existing prognostic scoring systems in CLD. It can be a valuable tool to streamline treatment protocols and prioritise liver transplantation.

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