MECHANISMS OF ENDOCOCHLEAR POTENTIAL GENERATION BY STRIA VASCULARIS

1987 ◽  
Vol 97 (8) ◽  
pp. 984???991 ◽  
Author(s):  
ALEC N. SALT ◽  
IVO MELICHAR ◽  
RUEDIGER THALMANN
1987 ◽  
Vol 81 (S1) ◽  
pp. S7-S7 ◽  
Author(s):  
Alec N. Salt ◽  
Ivo Melichar ◽  
Ruediger Thalmann

2002 ◽  
Vol 282 (2) ◽  
pp. C403-C407 ◽  
Author(s):  
Daniel C. Marcus ◽  
Tao Wu ◽  
Philine Wangemann ◽  
Paulo Kofuji

Stria vascularis of the cochlea generates the endocochlear potential and secretes K+. K+ is the main charge carrier and the endocochlear potential the main driving force for the sensory transduction that leads to hearing. Stria vascularis consists of two barriers, marginal cells that secrete potassium and basal cells that are coupled via gap junctions to intermediate cells. Mice lacking the KCNJ10 (Kir4.1) K+ channel in strial intermediate cells did not generate an endocochlear potential. Endolymph volume and K+ concentration ([K+]) were reduced. These studies establish that the KCNJ10 K+ channel provides the molecular mechanism for generation of the endocochlear potential in concert with other transport pathways that establish the [K+] difference across the channel. KCNJ10 is also a limiting pathway for K+ secretion.


2017 ◽  
Vol 29 (3) ◽  
pp. 585 ◽  
Author(s):  
Weiwei Guo ◽  
Haijin Yi ◽  
Zhang Yan ◽  
Lili Ren ◽  
Lei Chen ◽  
...  

The purpose of this study was to examine the morphological and functional development of the lateral wall of the scala media of the cochlea in miniature pigs; light and transmission electron microscopy and electrophysiology were used for this purpose. We showed that the lateral wall of the scala media of the cochlea appears at embryonic Day 21 (E21) when the cochlear duct begins to form. From E28 to E49, the lateral wall can be distinguished according to its position along the cochlea. At E56, cells in the lateral wall begin to differentiate into three different types. At E70, three cell types, marginal, intermediate and basal, can be clearly distinguished. At E91, the stria vascularis is adult-like and the organ of Corti is also morphologically mature. The average endocochlear potential measured from the second turn of the cochlea (at E98, postnatal Day 1 (P1), P13 and P30) was 71.4 ± 2.5 (n = 7), 78.8 ± 1.5 (n = 10), 77.3 ± 2.3 (n = 10) and 78.0 ± 2.1 mV (n = 10), respectively. Our results suggest that in miniature pigs the stria vascularis develops during the embryonic period, concurrent with maturation of the organ of Corti. The magnitude of the endocochlear potential reached its mature level when the stria vascularis was morphologically adult-like at E98. These findings provide a morphological and functional basis for future animal studies using the miniature pig model concerning the pathogenesis of various inner-ear diseases.


1987 ◽  
Vol 29 (2-3) ◽  
pp. 117-124 ◽  
Author(s):  
Franklin F. Offner ◽  
Peter Dallos ◽  
Mary Ann Cheatham

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Joseph McClellan ◽  
Wenxuan He ◽  
Joseline Raja ◽  
Gemaine Stark ◽  
Tianying Ren ◽  
...  

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