Effect of Cochlear Implantation on the Endocochlear Potential and Stria Vascularis

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Joseph McClellan ◽  
Wenxuan He ◽  
Joseline Raja ◽  
Gemaine Stark ◽  
Tianying Ren ◽  
...  
Keyword(s):  
Cochlear Implantation ◽  
Stria Vascularis ◽  
Endocochlear Potential

KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential

2002 ◽  
Vol 282 (2) ◽  
pp. C403-C407 ◽  
Author(s):  
Daniel C. Marcus ◽  
Tao Wu ◽  
Philine Wangemann ◽  
Paulo Kofuji
Keyword(s):  
Driving Force ◽  
Stria Vascularis ◽  
Endocochlear Potential ◽  
Sensory Transduction ◽  
Basal Cells ◽  
Transport Pathways ◽  
Main Charge ◽  
Marginal Cells ◽  
Intermediate Cells ◽  
Two Barriers

Stria vascularis of the cochlea generates the endocochlear potential and secretes K+. K+ is the main charge carrier and the endocochlear potential the main driving force for the sensory transduction that leads to hearing. Stria vascularis consists of two barriers, marginal cells that secrete potassium and basal cells that are coupled via gap junctions to intermediate cells. Mice lacking the KCNJ10 (Kir4.1) K+ channel in strial intermediate cells did not generate an endocochlear potential. Endolymph volume and K+ concentration ([K+]) were reduced. These studies establish that the KCNJ10 K+ channel provides the molecular mechanism for generation of the endocochlear potential in concert with other transport pathways that establish the [K+] difference across the channel. KCNJ10 is also a limiting pathway for K+ secretion.

The morphological and functional development of the stria vascularis in miniature pigs

2017 ◽  
Vol 29 (3) ◽  
pp. 585 ◽  
Author(s):  
Weiwei Guo ◽  
Haijin Yi ◽  
Zhang Yan ◽  
Lili Ren ◽  
Lei Chen ◽  
...  
Keyword(s):  
Animal Studies ◽  
Stria Vascularis ◽  
Organ Of Corti ◽  
Lateral Wall ◽  
Cell Types ◽  
Endocochlear Potential ◽  
Miniature Pigs ◽  
Functional Development ◽  
Transmission Electron ◽  
Different Types

The purpose of this study was to examine the morphological and functional development of the lateral wall of the scala media of the cochlea in miniature pigs; light and transmission electron microscopy and electrophysiology were used for this purpose. We showed that the lateral wall of the scala media of the cochlea appears at embryonic Day 21 (E21) when the cochlear duct begins to form. From E28 to E49, the lateral wall can be distinguished according to its position along the cochlea. At E56, cells in the lateral wall begin to differentiate into three different types. At E70, three cell types, marginal, intermediate and basal, can be clearly distinguished. At E91, the stria vascularis is adult-like and the organ of Corti is also morphologically mature. The average endocochlear potential measured from the second turn of the cochlea (at E98, postnatal Day 1 (P1), P13 and P30) was 71.4 ± 2.5 (n = 7), 78.8 ± 1.5 (n = 10), 77.3 ± 2.3 (n = 10) and 78.0 ± 2.1 mV (n = 10), respectively. Our results suggest that in miniature pigs the stria vascularis develops during the embryonic period, concurrent with maturation of the organ of Corti. The magnitude of the endocochlear potential reached its mature level when the stria vascularis was morphologically adult-like at E98. These findings provide a morphological and functional basis for future animal studies using the miniature pig model concerning the pathogenesis of various inner-ear diseases.

Positive endocochlear potential: Mechanism of production by marginal cells of stria vascularis

1987 ◽  
Vol 29 (2-3) ◽  
pp. 117-124 ◽  
Author(s):  
Franklin F. Offner ◽  
Peter Dallos ◽  
Mary Ann Cheatham
Keyword(s):  
Stria Vascularis ◽  
Endocochlear Potential ◽  
Potential Mechanism ◽  
Marginal Cells

Development of mammalian endocochlear potential: normal ontogeny and effects of anoxia

1986 ◽  
Vol 250 (3) ◽  
pp. R493-R498 ◽  
Author(s):  
N. K. Woolf ◽  
A. F. Ryan ◽  
J. P. Harris
Keyword(s):  
Glucose Metabolism ◽  
Mongolian Gerbil ◽  
Hair Cells ◽  
Stria Vascularis ◽  
Organ Of Corti ◽  
Endocochlear Potential ◽  
Cochlear Microphonic ◽  
Cochlear Hair Cells ◽  
Apical Membranes ◽  
Cochlear Microphonic Potential

The development of the positive endocochlear potential (EP), the negative anoxic EP, and the organ of Corti potential were measured at various postnatal ages in the Mongolian gerbil, beginning at 8 days after birth (DAB). The organ of Corti potential (OCP) was present at 8 DAB but averaged 21% less than the adult value. OCP increased regularly with age, reaching adult values of -90 mV by 14 DAB. The positive EP was first observed at 10 DAB, at which age it averaged only 2-3 mV. This potential increased monotonically between 10 and 20 DAB, by which time it had reached the adult value of 75 mV. Anoxia did not result in a negative EP until 12 DAB, at which age this potential averaged -7 mV. The negative anoxic EP matured more rapidly than the positive EP, achieving the adult value of 40 mV by 18 DAB. During development the positive EP appeared to closely parallel the maturation of glucose metabolism in the stria vascularis. The negative anoxic EP was more closely related temporally to the development of cochlear microphonic potential (CM) thresholds. It is hypothesized that changes which occur between 10 and 16 DAB in the apical membranes of the cochlear hair cells contribute to the maturation of both CM and the negative anoxic EP.

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