Blood Lead Levels, Paraoxonase-1 and Malondialdehyde in urban population from Southern Brazil

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Ana Carolina Bertin de Almeida Lopes* ◽  
Tiago Severo Peixe ◽  
André de Souza Nogueira ◽  
Ana Paula Michelin ◽  
Gustavo H Oliveira-Paula ◽  
...  
2012 ◽  
Vol 46 (2) ◽  
pp. 226-233 ◽  
Author(s):  
Mariana Maleronka Ferron ◽  
André Klafke de Lima ◽  
Paulo Hilário Nascimento Saldiva ◽  
Nelson Gouveia

OBJECTIVE: To estimate the prevalence of lead poisoning in children and to identify associated factors, as well as possible local sources of contamination. METHODS: A cross-sectional prevalence study conducted in 2006 with a random sample of 97 children age zero to five years from a neighborhood in Porto Alegre, Southern Brazil. Blood lead levels were measured and a questionnaire administered to collect information on sociodemographics, recycling and dwelling. A preliminary environmental evaluation was carried out with direct analysis of soil and indirect analysis of air pollution with bioindicators to identify possible sources of contamination. To analyze lead concentrations from the different collection sites, for each type of material studied, ANOVA was performed with a Brown-Forsythe adjustment for heteroscedasticity and with Dunnett's T3 procedure for multiple comparisons of unequal variances. RESULTS: Blood lead levels > 10.0 µg/dL was found in 16.5% of children. Recycling of waste at home, low father's education level, and increased age of children were associated with increase blood lead levels. High lead levels were found in soil, and there was little indication of lead air pollution. CONCLUSIONS: A high prevalence of lead poisoning was identified, and the potential sources of contamination in this community appear related to waste recylcing activities. Studies should be conducted with other populations of Brazilian children and evaluate potential sources of local and general contamination, to accurately characterize this issue in Brazil.


1988 ◽  
Vol 29 (6) ◽  
pp. 745-746 ◽  
Author(s):  
H. H. T. Madsen ◽  
T. Skjødt ◽  
P. J. Jørgensen ◽  
P. Grandjean

Author(s):  
Nam Soo Kim ◽  
Sung Woo Choi ◽  
Jin Ho Kim ◽  
Jung O Ham ◽  
Hae Yoon Park ◽  
...  

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Sahar Mahmoud Shawky ◽  
Reeham Abdel Aziz Abdel Hamid ◽  
Lina Essam Khedr

Abstract Background Pruritus is a common and often distressing symptom in patients with chronic kidney disease. Though the pathogenesis of uremic pruritus remains poorly understood, systemic inflammation has presented itself as one of the possible explanations. High blood lead levels (BLLs) have been noted to be associated with inflammation and poor nutritional status in hemodialysis patients. Our aim is to study the relation between blood lead levels and uremic pruritus. This is a cross-sectional study that enrolled 50 patients; all were on regular hemodialysis 3 times per week for at least 6 months. Patients were divided into 2 groups, group 1 (n =10) with no pruritus and group 2 (n=40) with varying degrees of pruritus. Group 2 was further divided according to intensity of pruritus by visual analog score (VAS) into mild (n=10), moderate (n=20), and severe pruritus (n=10). Results There was a significant difference in serum lead levels and ferritin levels between groups 1 and 2 (p value < 0.01 and < 0.05, respectively). There was a statistically significant difference in serum lead levels in the groups with varying intensity of pruritus, having higher serum lead levels in patients who exhibited severe pruritus (p value < 0.005) Moreover, a statistically significant relation between elevated blood lead levels and the duration of dialysis was observed in this study. Conclusion Uremic pruritus is a multi-factorial phenomenon, and our study showed that blood lead levels in hemodialysis patients might be associated with increased intensity of pruritus.


1981 ◽  
Vol 1 (2) ◽  
pp. 87-88
Author(s):  
V. P. Garnys ◽  
R. Freeman ◽  
L. E. Smythe

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