scholarly journals Expression and Role of Angiotensin II Type 2 Receptor in the Kidney and Mesangial Cells of Spontaneously Hypertensive Rats

2002 ◽  
Vol 25 (1) ◽  
pp. 125-133 ◽  
Author(s):  
Masahisa GOTO ◽  
Masashi MUKOYAMA ◽  
Akira SUGAWARA ◽  
Takayoshi SUGANAMI ◽  
Masato KASAHARA ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Spontaneously Hypertensive Rats ◽  
Mesangial Cells ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats

2015 ◽  
Vol 129 (6) ◽  
pp. 505-513 ◽  
Author(s):  
Mark Del Borgo ◽  
Yan Wang ◽  
Sanja Bosnyak ◽  
Morimer Khan ◽  
Pia Walters ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Angiotensin Ii ◽  
Protein Binding ◽  
Binding Site ◽  
Spontaneously Hypertensive Rats ◽  
Protective Effects ◽  
Ang Ii ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

We have synthesized a highly selective compound that is able to target a protein-binding site [called angiotensin (Ang) II type 2 receptor, AT2R] in the cardiovascular system. This research tool will enhance our ability to stimulate AT2R to produce protective effects against cardiovascular disease.

scholarly journals Intrarenal Aminopeptidase N Inhibition Restores Defective Angiotensin II Type 2-Mediated Natriuresis in Spontaneously Hypertensive Rats

Hypertension ◽  
2010 ◽  
Vol 55 (2) ◽  
pp. 474-480 ◽  
Author(s):  
Shetal H. Padia ◽  
Nancy L. Howell ◽  
Brandon A. Kemp ◽  
Marie-Claude Fournie-Zaluski ◽  
Bernard P. Roques ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Spontaneously Hypertensive Rats ◽  
Aminopeptidase N ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
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