scholarly journals Histopathological Characteristics of Spindle-cell Proliferative Disease in Broiler Chickens and Its Experimental Reproduction in Specific Pathogen-Free Chickens

2004 ◽  
Vol 66 (3) ◽  
pp. 231-235 ◽  
Author(s):  
Shigeaki TAKAMI ◽  
Masanobu GORYO ◽  
Toshiaki MASEGI ◽  
Kosuke OKADA
Keyword(s):  
Broiler Chickens ◽  
Spindle Cell ◽  
Specific Pathogen Free ◽  
Experimental Reproduction ◽  
Specific Pathogen ◽  
Proliferative Disease

scholarly journals Curcumin reduces enteric isoprostane 8-iso-PGF2α and prostaglandin GF2α in specific pathogen-free Leghorn chickens challenged with Eimeria maxima

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Victor M. Petrone-Garcia ◽  
Raquel Lopez-Arellano ◽  
Gabriela Rodríguez Patiño ◽  
Miriam Aide Castillo Rodríguez ◽  
Daniel Hernandez-Patlan ◽  
...  
Keyword(s):  
Pilot Study ◽  
Broiler Chickens ◽  
Solid Phase ◽  
Oxidation Products ◽  
Specific Pathogen Free ◽  
Post Challenge ◽  
Eimeria Maxima ◽  
Lipid Oxidation Products ◽  
Challenge Control ◽  
Specific Pathogen

AbstractThe purpose of this pilot study was to evaluate and determine the concentration of prostaglandin GF2α (PGF2α) and isoprostane 8‐iso‐PGF2α in plasma and intestine of specific pathogen-free (SPF) Leghorn chickens challenged with Eimeria maxima, with or without dietary supplementation of curcumin using solid‐phase microextraction and ultra‐performance liquid chromatography/tandem mass spectrometry. Eighty 1-day-old male SPF chickens were randomly allocated to one of four groups with four replicates (n = 5 chickens/replicate). Groups consisted of: (1) Control (no challenge), (2) Curcumin (no challenge), (3) Eimeria maxima (challenge), and (4) Eimeria maxima (challenge) + curcumin. At day 28 of age, all chickens in the challenge groups were orally gavaged with 40,000 sporulated E. maxima oocysts. No significant differences (P > 0.05) were observed in the groups regardless of the treatment or challenge with E. maxima. Enteric levels of both isoprostane 8‐iso‐PGF2α and PGF2α at 7 days and 9 days post-challenge were significantly increased (P < 0.01) compared to the non-challenge control chickens. Interestingly, the enteric levels of both isoprostane 8‐iso‐PGF2α and PGF2α at 7 days post-challenge were significantly reduced in chickens fed curcumin, compared to control chickens challenge with E. maxima. At 9 days post-challenge, only levels of isoprostane 8‐iso‐PGF2α in the enteric samples were significantly reduced in chickens challenged with E. maxima supplemented with curcumin, compared with E. maxima challenge chickens. No differences of isoprostane 8‐iso‐PGF2α or PGF2α were observed in plasma at both days of evaluation. Similarly, no significant differences were observed between the challenge control or chickens challenge with E. maxima and supplemented with curcumin at both times of evaluation. The results of this pilot study suggests that the antioxidant anti-inflammatory properties of curcumin reduced the oxidative damage and subsequent intestinal mucosal over-production of lipid oxidation products. Further studies to confirm and extend these results in broiler chickens are required.

scholarly journals Pathogenicity of Mycoplasma synoviae in Broiler Chickens

1998 ◽  
Vol 35 (3) ◽  
pp. 178-190 ◽  
Author(s):  
S. B. Lockaby ◽  
F. J. Hoerr ◽  
L. H. Lauerman ◽  
S. H. Kleven
Keyword(s):  
Broiler Chickens ◽  
Specific Pathogen Free ◽  
Skeletal System ◽  
Chain Reaction ◽  
Lesion Development ◽  
Mycoplasma Synoviae ◽  
Specific Pathogen ◽  
Upper Respiratory ◽  
Polymerase Chain

Six isolates of Mycoplasma synoviae, identified as WVU 1853, K1968, K1858, 92D8034, F10–2AS, and FMT, were compared for pathogenicity in broiler chickens. Specific-pathogen-free chickens were inoculated, in two groups of 20, with each isolate by footpad or eyedrop inoculation at 1 day of age and were examined at necropsy 7, 14, 28, and 42 days postinoculation. Specimens were taken for histopathology, culture, polymerase chain reaction assay, and hemagglutination-inhibition serology. Isolates were grouped according to pathogenicity on the basis of differences in lesion development and tissue distribution in the respiratory system, other viscera, and the skeletal system. K1968 (pathogenic) induced lesions in all sites examined in both the footpad and eyedrop inoculation groups. It was detected in all sites following footpad inoculation and in all sites except viscera following eyedrop inoculation. WVU 1853, K1858, and 92D8034 (moderately pathogenic) induced lesions and were detected in all sites following footpad inoculation. With eyedrop inoculation, lesions were identified only in upper and lower respiratory sites, and organisms were detected only in upper respiratory sites. F10–2AS (moderately pathogenic) was similar; however, footpad inoculation failed to induce visceral lesions or permit organism detection in any site. F10–2AS was detected in upper and lower respiratory tissues following eyedrop inoculation. FMT (mildly pathogenic) induced only upper respiratory lesions when either footpad or eyedrop inoculation was used, and detection was restricted to upper respiratory sites following eyedrop inoculation. These results are useful in comparative evaluations of the virulence of other M. synoviae isolates and form a basis for characterization of virulence factors of M. synoviae.

scholarly journals Systemic Spindle-Cell Proliferative Disease in Broiler Chickens

2005 ◽  
Vol 67 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Shigeaki TAKAMI ◽  
Masanobu GORYO ◽  
Toshiaki MASEGI ◽  
Kosuke OKADA
Keyword(s):  
Broiler Chickens ◽  
Spindle Cell ◽  
Proliferative Disease

A Dose-Response Study of Inactivated Low Pathogenic Avian Influenza H9N2 Virus in Specific-Pathogen-Free and Commercial Broiler Chickens

2016 ◽  
Vol 60 (1s) ◽  
pp. 256-261 ◽  
Author(s):  
Walid H. Kilany ◽  
Ahmed Ali ◽  
Abdel-Hamid I. Bazid ◽  
Ayman H. El-Deeb ◽  
Mohamed A. Zain El-Abideen ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Dose Response ◽  
Broiler Chickens ◽  
H9n2 Virus ◽  
Specific Pathogen Free ◽  
Pathogenic Avian Influenza ◽  
Specific Pathogen ◽  
Commercial Broiler ◽  
Dose Response Study ◽  
Avian Influenza H9n2

scholarly journals Chlamydia Psittaci Strains from Broiler Chickens Induce Histopathological Lesions and Mortality in SPF Chickens

2015 ◽  
Vol 59 (1) ◽  
pp. 43-50
Author(s):  
Lizi Yin ◽  
Isabelle Kalmar ◽  
Koen Chiers ◽  
Isolde Debyser ◽  
Daisy Vanrompay
Keyword(s):  
Broiler Chickens ◽  
Protein A ◽  
Chlamydia Psittaci ◽  
Specific Pathogen Free ◽  
Monitoring And Control ◽  
Zoonotic Pathogen ◽  
Histopathological Lesions ◽  
Specific Pathogen ◽  
Outer Membrane Protein A ◽  
And Control

Abstract A detailed study on histopathological lesions induced by two C. psittaci outer membrane protein A (ompA) genotype B strains (10/423 and 10/525) and one genotype D strain (10/298) in experimentally infected (aerosol) specific pathogen free (SPF) chickens was performed. The strains were derived from Belgian and French commercially raised broilers with pneumonia. Both genotype B and D strains induced conjunctivitis, rhinitis, sinusitis, tracheitis, bronchitis, pneumonitis, airsacculitis, splenitis, hepatitis, nephritis, and enteritis in sequentially (days 2 to 34 post infection) euthanized chickens. Inflammation of the ovaries was only observed in genotype D infected chickens. Overall, the genotype D strain caused more severe gross and histopathological lesions and mortality (54.5%) early upon infection. The genotype D strain seemed to replicate faster as severity of the lesions increased more quickly. C. psittaci is a primary pathogen in chickens, and efficient monitoring and control of this emerging zoonotic pathogen is urgently needed.

scholarly journals Der Lungentumor der Maus: ein progressiver Tumor

1974 ◽  
Vol 11 (5) ◽  
pp. 430-441 ◽  
Author(s):  
F. Deerberg ◽  
W. Pittermann ◽  
K. Rapp
Keyword(s):  
Statistical Analysis ◽  
Final Stage ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Time Dependent ◽  
Specific Pathogen Free ◽  
Pulmonary Tumor ◽  
Different Types ◽  
Specific Pathogen ◽  
Pulmonary Tumors

By subcutaneous serial transplantations of induced pulmonary tumors of mice a tumor progression has previously been correlated with the age of the tumors. The progression showed alterations from an alveolar-lining-type adenoma through papillary structures and different carcinomas to a spindle cell carcinoma in the final stage. Based on this report, 448 spontaneous pulmonary tumors in conventional and specific-pathogen-free Han: NMRI mice in different stages of life were classified. Six different types of pulmonary tumors were identified and compared with the age of the host. With increasing age of the host the pulmonary tumor tends to develop towards ultimate malignancy. Such a time-dependent transformation occurs regularly, as shown by a statistical analysis. A progression of primary spontaneous pulmonary tumors in mice is indicated as well.

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