Prenatal maternal anxiety promotes atopic dermatitis in offspring via placental DNA methylation changes

Aim: To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor ( NR3C1). Materials & methods: Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburgh Postnatal Depression Scale, respectively. NR3C1 methylation was determined at four methylation sites. Results: DNA methylation of CpG 1 in the NR3C1 CpG island shore was higher in infants born to women with high pregnancy anxiety (β 2.54, 95% CI: 0.49–4.58) and trait anxiety (β 1.68, 95% CI: 0.14–3.22). No significant association was found between depressive symptoms and NR3C1 methylation. Conclusion: We found that maternal anxiety was associated with increased NR3C1 CpG island shore methylation.

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Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Molecular Psychiatry ◽

10.1038/s41380-020-00976-0 ◽

2021 ◽

Author(s):

Sara Sammallahti ◽

Andrea P. Cortes Hidalgo ◽

Samuli Tuominen ◽

Anni Malmberg ◽

Rosa H. Mulder ◽

...

Keyword(s):

Dna Methylation ◽

Maternal Anxiety

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DNA Methylation Analysis of Lesional and Non-lesional Skin in Adult Patients with Atopic Dermatitis

Molekulyarnaya Meditsina (Molecular medicine) ◽

10.29296/24999490-2021-01-08 ◽

2021 ◽

Vol 19 (1) ◽

pp. 53-64

Author(s):

Olga Smolkina ◽

Elizaveta Bystritskaia ◽

Oksana Svitich ◽

Anastas Piruzyan ◽

Elena Denisova ◽

...

Keyword(s):

Dna Methylation ◽

Atopic Dermatitis ◽

Adult Patients ◽

Methylation Analysis ◽

Lesional Skin ◽

Dna Methylation Analysis

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DNA methylation profile in the skin of patients with atopic dermatitis

Voprosy praktičeskoj pediatrii ◽

10.20953/1817-7646-2019-5-66-70 ◽

2019 ◽

Vol 14 (5) ◽

pp. 66-70

Author(s):

N.G. Kochergin ◽

◽

L.N. Kayumova ◽

T.M. Zavarykina ◽

A.Yu. Asanov ◽

...

Keyword(s):

Dna Methylation ◽

Atopic Dermatitis ◽

Methylation Profile ◽

Dna Methylation Profile

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Prenatal maternal anxiety related with dietary pattern may promote atopic dermatitis in offspring through the alteration of gut microbiota

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2018.12.403 ◽

2019 ◽

Vol 143 (2) ◽

pp. AB133

Author(s):

So-Yeon Lee ◽

Mi-Jin Kang ◽

Sung-Ok Kwon ◽

Yoon Mee Park ◽

Bong-Soo Kim ◽

...

Keyword(s):

Atopic Dermatitis ◽

Gut Microbiota ◽

Dietary Pattern ◽

Maternal Anxiety

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Prenatal 25-hydroxyvitamin D deficiency affects development of atopic dermatitis via DNA methylation

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2018.10.010 ◽

2019 ◽

Vol 143 (3) ◽

pp. 1215-1218 ◽

Cited By ~ 7

Author(s):

Hyun-Ju Cho ◽

Youn Ho Sheen ◽

Mi-Jin Kang ◽

Seung-Hwa Lee ◽

So-Yeon Lee ◽

...

Keyword(s):

Dna Methylation ◽

Atopic Dermatitis ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Epigenetic alterations in skin homing CD4+CLA+ T cells of atopic dermatitis patients

Scientific Reports ◽

10.1038/s41598-020-74798-z ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Nathalie Acevedo ◽

Rui Benfeitas ◽

Shintaro Katayama ◽

Sören Bruhn ◽

Anna Andersson ◽

...

Keyword(s):

Dna Methylation ◽

T Cells ◽

Atopic Dermatitis ◽

Regulatory Elements ◽

Upstream Region ◽

Cytokine Signaling ◽

Integrated Network ◽

Molecular Alterations ◽

Protein Ubiquitination ◽

Skin Homing

Abstract T cells expressing the cutaneous lymphocyte antigen (CLA) mediate pathogenic inflammation in atopic dermatitis (AD). The molecular alterations contributing to their dysregulation remain unclear. With the aim to elucidate putative altered pathways in AD we profiled DNA methylation levels and miRNA expression in sorted T cell populations (CD4+, CD4+CD45RA+ naïve, CD4+CLA+, and CD8+) from adult AD patients and healthy controls (HC). Skin homing CD4+CLA+ T cells from AD patients showed significant differences in DNA methylation in 40 genes compared to HC (p < 0.05). Reduced DNA methylation levels in the upstream region of the interleukin-13 gene (IL13) in CD4+CLA+ T cells from AD patients correlated with increased IL13 mRNA expression in these cells. Sixteen miRNAs showed differential expression in CD4+CLA+ T cells from AD patients targeting genes in 202 biological processes (p < 0.05). An integrated network analysis of miRNAs and CpG sites identified two communities of strongly interconnected regulatory elements with strong antagonistic behaviours that recapitulated the differences between AD patients and HC. Functional analysis of the genes linked to these communities revealed their association with key cytokine signaling pathways, MAP kinase signaling and protein ubiquitination. Our findings support that epigenetic mechanisms play a role in the pathogenesis of AD by affecting inflammatory signaling molecules in skin homing CD4+CLA+ T cells and uncover putative molecules participating in AD pathways.

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