scholarly journals Mechanism and Kinetics of Stabilization Reactions of Polyacrylonitrile and Related Copolymers IV. Effects of Atmosphere on Isothermal DSC Thermograms and FT-IR Spectral Changes during Stabilization Reaction of Acrylonitrile/Methacrylic Acid Copolymer

1998 ◽  
Vol 30 (6) ◽  
pp. 463-469 ◽  
Author(s):  
Hideto Kakida ◽  
Kohji Tashiro
Keyword(s):  
Methacrylic Acid ◽  
Spectral Changes ◽  
Acid Copolymer ◽  
Ft Ir ◽  
Mechanism And Kinetics ◽  
Kinetics Of ◽  
Dsc Thermograms

Crosslinking of Gelatin in the Reaction with Formaldehyde: An FT-IR Spectroscopic Study

1996 ◽  
Vol 50 (10) ◽  
pp. 1314-1318 ◽  
Author(s):  
T. Salsa ◽  
M. E. Pina ◽  
J. J. C. Teixeira-Dias
Keyword(s):  
Principal Component Regression ◽  
Principal Component ◽  
Potassium Bromide ◽  
Crosslinking Reaction ◽  
Spectral Changes ◽  
Principal Component Regression Analysis ◽  
Ft Ir ◽  
Ir Spectroscopic ◽  
Kinetics Of ◽  
Ft Ir Spectroscopy

The reaction of an aqueous solution of formaldehyde with gelatin dispersed in a potassium bromide pellet is monitored in real time by FT-IR spectroscopy. Principal component regression analysis of the spectra recorded at different times is carried out. On the whole, the latter results and the observed spectral changes are in agreement with a previously reported interpretation for the kinetics of the crosslinking reaction of gelatin with formaldehyde, according to which the reaction is initialized by the lysine–methylol formation and is subsequently followed by arginine–methylol, which, in turn, reacts with lysine–methylol to originate arginine–lysine crosslinks.

Design and Evaluation of Sustained Release Solid Dispersions of Verapamil Hydrochloride

2011 ◽  
Vol 3 (4) ◽  
pp. 1252-1262
Author(s):  
Swain S K ◽  
Niranjan Patra Patra ◽  
Sruti J ◽  
M.E. Bhanoji Rao
Keyword(s):  
Solid Dispersions ◽  
Verapamil Hydrochloride ◽  
Ir Studies ◽  
Dissolution Properties ◽  
Rate Of Dissolution ◽  
Release Studies ◽  
Ft Ir ◽  
Mechanism And Kinetics ◽  
Model Drug ◽  
Kinetics Of

The Purpose of this study was to prepare and characterize solid dispersions of this antiarrhythmic drug Verapamil hydrochloride (VPH) with HPMCK4M, EudragitRSPO and their combination with a view to sustain its dissolution properties. Investigation of the properties of the prepared solid dispersions were performed using release studies and Fourier transform infrared (FT-IR). The results obtained showed that the rate of dissolution of Verapamil hydrochloride was considerably more sustained when formulated in solid dispersions with HPMCK4M and Eudragit RSPO as compared with pure drug and physical mixtures. FT-IR studies confirmed absence of any possible solid state drug and polymer interactions. In order to establish the mechanism and kinetics of drug release, the experimental data was fitted to different kinetic models likes zero order, first order, Higuchi’s model, korsmeyer peppa’s model. From the above research it may be concluded that HPMCK4M acts as a better release retardant for the model drug.

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