Acute hepatitis C infection with secondary liver injury successfully treated with sofosbuvir/velpatasvir combination

2020 ◽  
Vol 81 (8) ◽  
pp. 1-3
Author(s):  
Sarah Micallef ◽  
James Gauci ◽  
Jurgen Gerada
Keyword(s):  
Hepatitis C ◽  
Liver Injury ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection

Treatment of acute hepatitis C infection with interferon-alfa 2b monotherapy prevents development of chronic HCV infection

2001 ◽  
Vol 120 (5) ◽  
pp. A567-A567 ◽  
Author(s):  
E JAECKEL ◽  
M CORNBERG ◽  
T SANTANTONIO ◽  
J MAYER ◽  
H WEDEMEYER ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Interferon Alfa ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Long-lasting Imprint in the Soluble Inflammatory Milieu despite Early Treatment of Acute Symptomatic Hepatitis C

2021 ◽  
Author(s):  
Tanvi Khera ◽  
Yanqin Du ◽  
Daniel Todt ◽  
Katja Deterding ◽  
Benedikt Strunz ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Partial Restoration ◽  
Acute Hcv ◽  
Direct Acting ◽  
Inflammatory Milieu

Abstract Background Treatment with direct acting antivirals (DAAs) in patients with chronic hepatitis C infection leads to partial restoration of soluble inflammatory mediators (SIMs). In contrast, we hypothesized that early DAA treatment of acute hepatitis C with DAAs may normalize most SIMs. Methods In this study, we made use of a unique cohort of acute symptomatic hepatitis C who cleared HCV with a 6-week course of ledipasvir/sofosbuvir. Plasma samples were used for proximity extension assay (PEA) measuring 92 proteins. Results Profound SIM alterations were observed in acute HCV patients, with marked upregulation of IL-6 and CXCL10 while certain mediators were down-regulated (e.g. MCP-4, IL-7). During treatment and follow-up, the majority of SIMs decreased but not all normalized (e.g. CDCP1, IL-18). Of note, SIMs that were down-regulated before DAA treatment remained suppressed while others that were initially unchanged, declined to lower values during treatment and follow-up (e.g.CD244). Conclusions Acute hepatitis C was associated with marked changes in the soluble inflammatory milieu as compared to both chronic hepatitis patients and healthy controls. Whereas early DAA treatment partly normalized this altered signature, long-lasting imprints of HCV remained. Thus, acute HCV-induced changes in the immune system may persist even after a short duration of viremia.

Acute hepatitis C infection in HIV-negative men who have sex with men

2014 ◽  
Vol 22 (6) ◽  
pp. 535-538 ◽  
Author(s):  
K. McFaul ◽  
A. Maghlaoui ◽  
M. Nzuruba ◽  
S. Farnworth ◽  
M. Foxton ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Sex With Men ◽  
Hiv Negative

scholarly journals Early treatment of acute hepatitis C infection is cost-effective in HIV-infected men-who-have-sex-with-men

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0210179 ◽  
Author(s):  
Stephanie Popping ◽  
Sebastiaan J. Hullegie ◽  
Anne Boerekamps ◽  
Bart J. A. Rijnders ◽  
Robert J. de Knegt ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Early Treatment ◽  
Cost Effective ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Sex With Men

Incidence and risk for acute hepatitis C infection during imprisonment in Australia

2010 ◽  
Vol 25 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Kate Dolan ◽  
Suzy Teutsch ◽  
Nicolas Scheuer ◽  
Michael Levy ◽  
William Rawlinson ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection

Fulminant Liver Failure Due to Acute Hepatitis C Infection in the Setting of AIDS

2014 ◽  
Vol 109 ◽  
pp. S388
Author(s):  
Janhavi Athale ◽  
Ahmet Gurakar ◽  
Esteban Mezey ◽  
Naudia Jonassaint ◽  
Mark Sulkowski ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Liver Failure ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Fulminant Liver Failure ◽  
Hepatitis C Infection
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