Hypertrophic scar formation after skin injury

1993 ◽  
Vol 2 (5) ◽  
pp. 299-302 ◽  
Author(s):  
S. A. Carney
Keyword(s):  
Hypertrophic Scar ◽  
Scar Formation ◽  
Skin Injury

scholarly journals LncRNA TRHDE-AS1 inhibit the scar fibroblasts proliferation via miR-181a-5p/PTEN axis

2021 ◽  
Author(s):  
Yanping Wei ◽  
Tingting Wang ◽  
Ningning Zhang ◽  
Yunyun Ma ◽  
Siji Shi ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Therapeutic Target ◽  
Hypertrophic Scar ◽  
Scar Formation ◽  
Invasive Growth ◽  
Skin Injury ◽  
Non Coding Rna ◽  
Direct Target ◽  
Proliferation Suppression

AbstractHypertrophic scar (HS), a fibroproliferative disorder caused by abnormal wound healing after skin injury, which is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. Recent studies have shown that some non-coding RNA implicated the formation of HS, but the mechanism remains unclear. In this study, we found that lncRNA TRHDE-AS1 was downregulated in HS tissues and HSFs, and the level of lncRNA TRHDE-AS1 negatively correlated with the level of miR-181a-5p in HS tissue and HSFs. Overexpressed lncRNA TRHDE-AS1 significantly suppressed miR-181a-5p level, while promoted HSFs apoptosis and inhibited HSFs proliferation. Further study shown that PTEN was a direct target of miR-181a-5p, and lncRNA TRHDE-AS1 served as a molecular sponge for miR-181a-5p to regulate the expression of PTEN. Overexpression of PTEN could eliminate lncRNA TRHDE-AS1-mediated proliferation suppression of HSFs. In conclusion, our study suggested that lncRNA TRHDE-AS1/miR-181a-5p/PTEN axis plays an important role in promoting hypertrophic scar formation, which may be effectively used as a therapeutic target for hypertrophic scar treatment.

scholarly journals Use of tape for the management of hypertrophic scar development: A comprehensive review

2021 ◽  
Vol 7 ◽  
pp. 205951312110292 ◽  
Author(s):  
Sarah O’Reilly ◽  
Erin Crofton ◽  
Jason Brown ◽  
Jennifer Strong ◽  
Jenny Ziviani
Keyword(s):  
Hypertrophic Scar ◽  
Wound Closure ◽  
Positive Impact ◽  
Formal Analysis ◽  
Healing Process ◽  
Preliminary Evidence ◽  
Scar Formation ◽  
Comprehensive Review ◽  
Mesh Terms ◽  
Scar Management

Introduction: Tapes have been used to aid fresh wound closure. For hypertrophic scars, the use of tapes as a therapy to reduce the mechanical forces that stimulate excessive and long-term scarring is yet to be evaluated. The aim of this comprehensive review was to explore the current clinical application of tapes, as a minimally invasive option, as purposed specifically for the management of hypertrophic scarring, regardless of scar causation. Method: Databases were searched using MeSH terms including one identifier for hypertrophic scar and one for the intervention of taping. Studies included the following: patients who received tape for a minimum of 12 weeks as a method of wound closure specifically for the purpose of scar prevention; those who received tape as a method of scar management after scar formation; reported outcomes addressing subjective and/or objective scar appearance; and were available in English. Results: With respect to non-stretch tapes, their use for the prevention of linear surgical scarring is evident in reducing scar characteristics of height, colour and itch. Statistically significant results were found in median scar width, reduction in procedure times and overall scar rating. Tapes were predominately applied by participants themselves, and incidence of irritation was infrequently reported. After 12 months, significance with respect to scar pain, itch, thickness and overall scar elevation was reported in one study investigating paper tape. Two papers reported the use of high stretch tapes; however, subjective results limited formal analysis. Although the use of taping for abnormal hypertrophic scar management is in its infancy, emerging research indicates tapes with an element of stretch may have a positive impact. Conclusions: Non-stretch tapes, for the prevention of linear surgical scarring, are effective in reducing scar characteristics of height, colour and itch. Paper tapes have shown effectiveness when applied during wound remodelling or even on mature scarring, with reported subjective changes in scar colour, thickness and pliability. Preliminary evidence of the benefits of high-stretch, elasticised tapes for scar management in the remodelling phase of wound healing have also been reported. Lay Summary Patients are often concerned about unsightly scars that form on their bodies after trauma, especially burn injuries. These scars can be thick, red and raised on the skin, and can impact on the patient’s quality of life. For some scars, the process of skin thickening continues for up to two years after an injury. Unfortunately, scar formation is a part of the body’s healing process, whereby there is a constant pull or tension under and along the skin’s surface. The use of simple tapes, such as microporetm, to help with wound closure are sometimes used as a therapy to reduce the tension on the skin’s surface when a wound is healing to minimise scar formation. However, the effectiveness of taping has not been proven. This paper looks at the available evidence to support the use of taping to reduce scar features of height, thickness and colour. Initial evidence of mixed levels, suggests some benefits of tapes for scar management and show preliminary efficacy for reduction of scar height, thickness and colour. More research is required to determine the direct impact, comparison to other treatments available and patient viewpoint for this therapy.

scholarly journals Inhibition of hypertrophic scar formation with oral asiaticoside treatment in a rabbit ear scar model

2021 ◽  
Author(s):  
Jia Huang ◽  
Xiaobo Zhou ◽  
Lingling Xia ◽  
Weiwei Liu ◽  
Fei Guo ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
Scar Formation ◽  
Rabbit Ear

scholarly journals Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway

2015 ◽  
Vol 37 (2) ◽  
pp. 666-676 ◽  
Author(s):  
Ting He ◽  
Xiaozhi Bai ◽  
Longlong Yang ◽  
Lei Fan ◽  
Yan Li ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
Ex Vivo ◽  
Scar Tissue ◽  
Scar Formation ◽  
Jnk Pathway ◽  
Protein Levels ◽  
Mapk Inhibitors ◽  
Hypertrophic Scar Tissue ◽  
Loureirin B ◽  
Tgf Β1

Background/Aims: Our previous study confirmed that Loureirin B (LB) can inhibit hypertrophic scar formation. However, the mechanism of LB-mediated inhibition of scar formation is still unknown. Methods: Immunohistochemistry was used to detect expression of Col1, FN and TGF-β1 in skin and scar tissue. Fibroblasts were stimulated with TGF-β1 to mimic scar formation. LB or MAPK inhibitors were used to study the pathways involved in the process. Western blotting was used to evaluate the expression of p-JNK, p-ERK, p-p38, Col1 and FN. The contractile capacity of fibroblasts was evaluated using a gel contraction assay. Tissues were cultured ex vivo with LB to further investigate the participation of ERK and JNK in the LB-mediated inhibition of scar formation. Results: FN and Col1 were up regulated in hypertrophic scars. LB down regulated p-ERK and p-JNK in TGF-β1-stimulated fibroblasts, while levels of phosphorylated p38 did not change. The down regulation of p-ERK and p-JNK was associated with a reduction of Col1 and FN. Similarly, inhibition of ERK and JNK down regulated the expression of Col1 and FN in TGF-β1-stimulated fibroblasts. LB down regulated protein levels of p-ERK and p-JNK in cultured hypertrophic scar tissue ex vivo. Conclusions: This study suggests that LB can inhibit scar formation through the ERK/JNK pathway.

Time course of the angiogenic response during normotrophic and hypertrophic scar formation in humans

2011 ◽  
Vol 19 (3) ◽  
pp. 292-301 ◽  
Author(s):  
Willem M. van der Veer ◽  
Frank B. Niessen ◽  
José A. Ferreira ◽  
Peter J. Zwiers ◽  
Etty H. de Jong ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
Time Course ◽  
Scar Formation ◽  
Angiogenic Response

Comparative evaluations of hypertrophic scar formation in in vivo models

2018 ◽  
Vol 50 (6) ◽  
pp. 661-668 ◽  
Author(s):  
Myeongjin Kim ◽  
Hyejin Kim ◽  
Hyun Wook Kang
Keyword(s):  
Hypertrophic Scar ◽  
Scar Formation ◽  
In Vivo Models

Endostar Injection Inhibits Rabbit Ear Hypertrophic Scar Formation

2012 ◽  
Vol 11 (4) ◽  
pp. 271-276 ◽  
Author(s):  
Wang ZhiYong ◽  
Song Fei ◽  
Xu LianJu ◽  
Liu Yingkai ◽  
Qing Chun ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
Scar Formation ◽  
Rabbit Ear
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