Analysis of the changes in cell morphology and cell contractility during vascular smooth muscle differentiation processes using traction force microscopy

2018 ◽  
Vol 2018.29 (0) ◽  
pp. 2A11
Author(s):  
Harunobu TATSUNO ◽  
Kazuaki NAGAYAMA
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Cell Morphology ◽  
Traction Force ◽  
Muscle Differentiation ◽  
Traction Force Microscopy ◽  
Force Microscopy ◽  
Cell Contractility ◽  
Smooth Muscle Differentiation

scholarly journals Transcription factor TEAD1 is essential for vascular development by promoting vascular smooth muscle differentiation

2019 ◽  
Vol 26 (12) ◽  
pp. 2790-2806 ◽  
Author(s):  
Tong Wen ◽  
Jinhua Liu ◽  
Xiangqin He ◽  
Kunzhe Dong ◽  
Guoqing Hu ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Vascular Development ◽  
Muscle Differentiation ◽  
Smooth Muscle Differentiation

Vascular smooth muscle differentiation of murine stroma

1999 ◽  
Vol 27 (12) ◽  
pp. 1782-1795 ◽  
Author(s):  
Jean-Paul Remy-Martin ◽  
Aliette Marandin ◽  
Bruno Challier ◽  
Gabrielle Bernard ◽  
Marie Deschaseaux ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Differentiation ◽  
Smooth Muscle Differentiation

Transforming growth factor-beta dynamically regulates vascular smooth muscle differentiation in vivo

1998 ◽  
Vol 111 (19) ◽  
pp. 2977-2988 ◽  
Author(s):  
D.J. Grainger ◽  
J.C. Metcalfe ◽  
A.A. Grace ◽  
D.E. Mosedale
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Muscle Differentiation ◽  
Tgf Beta ◽  
Differentiation Markers ◽  
Smooth Muscle Tissue ◽  
Smooth Muscle Differentiation

Variations in the levels of smooth muscle-specific isoforms of contractile proteins have been reported to occur in many different vascular diseases. However, although much work has been done in vitro to investigate the regulation of smooth muscle cell differentiation, the molecular mechanisms which regulate the differentiation of vascular smooth muscle tissue in vivo are unknown. Using quantitative immunofluorescence, we show that in rat arteries levels of smooth muscle differentiation markers correlate with the levels of the cytokine TGF-beta. In young mice with one allele of the TGF-beta1 gene deleted, the levels of both TGF-beta1 and smooth muscle differentiation markers are reduced compared to wild-type controls. This regulation of smooth muscle differentiation by TGF-beta during post-natal development also occurs dynamically in the adult animal. Following various pharmacological or surgical interventions, including treatment of mice with tamoxifen and balloon injury of rat carotid arteries, there is a strong correlation between the changes in the levels of TGF-beta and changes in the levels of smooth muscle differentiation markers (r=0. 9, P<0.0001 for n=26 experiments). We conclude that TGF-beta dynamically regulates smooth muscle differentiation in rodent arteries in vivo.

scholarly journals The Dichotomy of Vascular Smooth Muscle Differentiation/De- Differentiation in Health and Disease

2018 ◽  
Author(s):  
Mariana di Luca ◽  
Roya Hakimjavadi ◽  
Denise Burtenshaw ◽  
Emma Fitzpatrick ◽  
Pattie Mathiue ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Differentiation ◽  
Health And Disease ◽  
Smooth Muscle Differentiation

foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish

2019 ◽  
Vol 453 (1) ◽  
pp. 34-47 ◽  
Author(s):  
Thomas R. Whitesell ◽  
Paul W. Chrystal ◽  
Jae-Ryeon Ryu ◽  
Nicole Munsie ◽  
Ann Grosse ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Differentiation ◽  
Smooth Muscle Differentiation ◽  
Embryonic Head
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