Hepatitis B virus-related liver cirrhosis complicated with dermatomyositis: A case report

Abstract Background Cerebral microbleeds (CMBs) are small, rounded, dark-signal lesions on brain MRI that represent cerebral hemosiderin deposits resulting from prior microhemorrhages and are neuroimaging biomarkers of cerebral amyloid angiopathy (CAA). Here, we report a case of innumerable CMBs in a patient with hepatic encephalopathy underlying decompensated liver cirrhosis. Case presentation An 83-year-old woman diagnosed with hepatitis B virus-related liver cirrhosis 40 years before was referred to our neurology clinic for progressive disorientation of time and place, personality changes, and confusion with somnolence over 2 weeks. Based on the laboratory, neuroimaging, and electrophysiological findings, we diagnosed the patient with hepatic encephalopathy, and her symptoms recovered within 12 h after proper medical management. Brain MRI showed innumerable CMBs in the bilateral frontal, parietal, temporal, and occipital lobes. Since the distribution of CMBs in the patient was mainly corticosubcortical and predominantly in the posterior cortical regions, and the apolipoprotein E genotype was ε4/ε4, we speculated that CAA and hepatic encephalopathy coexisted in this patient. Conclusions We suggest that severe liver dysfunction associated with long-term decompensated liver cirrhosis may be related to an increased number of CMBs in the brain. Our findings indicate that decompensated liver cirrhosis may be a risk factor for the development of CMBs and corroborate a link between the liver and the brain.

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Association of polymorphisms of human leucocyte antigen-DQA1 and DQB1 alleles with chronic hepatitis B virus infection, liver cirrhosis and hepatocellular carcinoma in Chinese

International Journal of Immunogenetics ◽

10.1111/j.1744-313x.2007.00702.x ◽

2007 ◽

Vol 34 (5) ◽

pp. 373-378 ◽

Cited By ~ 16

Author(s):

C. Liu ◽

B. Cheng

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Cirrhosis ◽

Chronic Hepatitis ◽

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Human Leucocyte Antigen ◽

Hepatitis B Virus Infection ◽

Chronic Hepatitis B Virus ◽

B Virus

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Proportion of Nonalcoholic Steatohepatitis in Patients with Chronic Liver Disease

10.53350/pjmhs211561272 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1272-1274

Author(s):

H.A. Abro ◽

B. A. Shaikh ◽

A. H. Mugheri ◽

I. A. Ansari ◽

Z. A. Shaikh ◽

...

Keyword(s):

Liver Cirrhosis ◽

Hepatitis C Virus ◽

Liver Disease ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Nonalcoholic Steatohepatitis ◽

Smoking Status ◽

Virus Hepatitis ◽

B Virus

Aim: To determine the frequency of nonalcoholic steatohepatitis in patients with liver cirrhosis. Study Design: Retrospective/observational Place and Duration of Study: Department of Medicine, Chandka Medical College Hospital, Larkana from 1st July 2020 to 31st March 2021. Methodology: One hundred and twenty patients of both genders presented with liver cirrhosis were enrolled in this study. Patient’s detailed demographics including age, sex, body mass index, smoking status, alcohol consumption and family history of liver disease were recorded after taking written informed consent. Laboratory examination was done to examine the proportion of hepatitis B virus, hepatitis C virus and nonalcoholic steatohepatitis. Results: There were 68 (56.67%) males and 52 (43.33%) were females with mean age 45.74±10.54 years. Among all the patients hepatitis C virus was found in 62 (51.67%) patients, 15 (12.5%) had hepatitis B virus, 17 (14.17%) had hepatitis B virus + hepatitis C virus and nonalcoholic steatohepatitis was found in 26 (21.67%) patients. Conclusion: Nonalcoholic steatohepatitis was the major cause of liver cirrhosis in Pakistani population. The proportion of NASH in liver cirrhosis patients was 21.67%. Keywords: Nonalcoholic steatohepatitis (NASH), Liver Cirrhosis, Hepatitis B virus, Hepatitis C virus

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Clinical characteristics of patients with hepatitis B virus related liver cirrhosis and primary liver cancer

World Chinese Journal of Digestology ◽

10.11569/wcjd.v23.i17.2798 ◽

2015 ◽

Vol 23 (17) ◽

pp. 2798

Author(s):

Feng Lv ◽

Yu-Feng Gao ◽

Jian-Guo Rao ◽

Wei Zhang ◽

Gui-Zhou Zou ◽

...

Keyword(s):

Liver Cirrhosis ◽

Hepatitis B Virus ◽

Liver Cancer ◽

Hepatitis B ◽

Clinical Characteristics ◽

Primary Liver Cancer ◽

B Virus

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Genetic polymorphisms of interleukin-6 influence the development of hepatitis B virus-related liver cirrhosis

10.21203/rs.2.522/v1 ◽

2019 ◽

Author(s):

Caixia Xia ◽

Wei Zhu ◽

Chunhong Huang ◽

Guohua Lou ◽

Bingjue Ye ◽

...

Keyword(s):

Liver Cirrhosis ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Interleukin 6 ◽

Serum Levels ◽

Healthy Controls ◽

Nucleotide Polymorphisms ◽

Cross Sectional ◽

B Virus ◽

Infected Liver

Abstract Background Interleukin-6 (IL-6) plays an important role in chronic inflammation. Thus, we aimed to investigate the effects of IL-6 polymorphisms in predicting the progression of hepatitis B virus (HBV) -related liver cirrhosis. Methods A cross-sectional study was conducted to analysis IL-6 polymorphisms and serum levels of IL-6 in HBV-infected patients of different clinical phases and in healthy controls. IL-6 polymorphisms were detected by Taqman PCR method and plasma IL-6 levels were assessed by ELISA. Results Our analysis included 182 chronic hepatitis B (CHB) patients, 190 HBV-infected liver cirrhosis cases, 125 inactive HBsAg carriers, and 246 healthy controls. Seven SNPs in IL-6 including rs10499563, rs17147230, rs1800796, rs2069837, rs1524107, rs2066992, rs2069852 were analyzed. In haplotype analysis between HBV-infected liver cirrhosis cases with CHB patients, inactive HBV-carriers or healthy controls, haplotype CT in block 1 and haplotype GGCGG in block 2 were associated with liver cirrhosis (P<0.05). What’s more, the genotype or allele frequencies were significantly different in IL-6 rs10499563 and rs2069837 when HBV-infected liver cirrhosis patients compared with CHB patients, inactive HBV-carriers or healthy controls. A further study found that compared with the controls or CHB patients, plasma IL-6 was elevated in HBV-infected liver cirrhosis patients (P<0.05). Conclusion In conclusion, the polymorphisms of the IL-6 rs10499563 and rs2069837 are associated with the susceptibility of liver cirrhosis may through their effects on IL-6 expressions and these two single nucleotide polymorphisms can be used as potential predicting markers for prognosis of HBV-infected liver cirrhosis.

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