Effects ofEurycoma longifoliaJack on Copulatory Behavior in Middle-Aged Male Rats

2002 ◽  
Vol 9 (1) ◽  
pp. 109-114 ◽  
Author(s):  
H. H. Ang ◽  
H. S. Cheang
Keyword(s):  
Copulatory Behavior ◽  
Male Rats ◽  
Middle Aged ◽  
Middle Aged Male

Genistein Increase Thyroid Hormone and 7 alpha-hydroxycholesterol concentrations in the liver of middle-aged male rats

2018 ◽  
Author(s):  
Branka Sosic-Jurjevic ◽  
Dieter Lutjohann ◽  
Dragana Miljic ◽  
Jasmina Ciric ◽  
Svetlana Trifunovic ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Male Rats ◽  
Middle Aged ◽  
Middle Aged Male

scholarly journals Initiation of calorie restriction in middle-aged male rats attenuates aging-related motoric decline and bradykinesia without increased striatal dopamine

2016 ◽  
Vol 37 ◽  
pp. 192-207 ◽  
Author(s):  
Michael F. Salvatore ◽  
Jennifer Terrebonne ◽  
Victoria Fields ◽  
Danielle Nodurft ◽  
Cori Runfalo ◽  
...  
Keyword(s):  
Calorie Restriction ◽  
Striatal Dopamine ◽  
Male Rats ◽  
Middle Aged ◽  
Middle Aged Male

Effects of Chinese Herbal Prescriptions on Copulatory Activity in Aged Male Rats: A Preliminary Study

1998 ◽  
Vol 26 (01) ◽  
pp. 83-90 ◽  
Author(s):  
Hui-Chiu Chang ◽  
Sheng-l Lue ◽  
Chin Hsu ◽  
Hseng-Kuang Hsu ◽  
Ching-Feng Weng ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Copulatory Behavior ◽  
Male Rats ◽  
Aged Rats ◽  
Middle Aged ◽  
Promotional Effect ◽  
Before And After ◽  
Copulatory Activity ◽  
Old Rats ◽  
Herbal Prescription

Four herbal prescription medicines, Chi-Pao-Mei-Jan-Tan, Gui-Fu-Ba-Wei-Wan, Huan-Shao-Tan; and San Tsai-Feng-Sui-Tan, were tested for their effects on sexual behavior in aged rats. Crude liquid extracts of these herbs were administered to the rats daily through oral tubing for 14 days. All four herbal prescriptions showed some effects in restoration of mount and intromission behaviors, but there was no effect on restoration of ejaculation in 26 month old rats that had exhibited no copulatory activity (no mount, intromission and ejaculation) previously. The effects of Chi-Pao-Mei-Jan-Tan were further tested in 26 month old rats with low mount and intromission activities but without ejaculation behavior, and in 15 month old rats (middle-age group) that showed normal mount and intrornission behavior but no ejaculation activity. Chi-Pao-Mei-Jan-Tan was effective in improving the frequency of both mount and intromission, but failed to restore the ejaculation activity of the old rats with low mount and intromission behaviors. It was, however, very effective in restoration of ejaculation activity in middle-aged rats that exhibited normal mount and intromission behaviors. Serum testosterone (T) levels of Chi-Pao-Mei-Jan- Tan in tested old and middle-aged rats were determined by radioimmunoassay, and showed no difference before and after treatment. Our findings demonstrated that the four herbal prescriptions had some effects in restoration of mount and intromission behaviors, but not ejaculation activity in old rats, and that Chi-Pao-Mei-Jan-Tan was very effective in restoration of ejaculation activity in middle-aged rats. The promotional effect of Chi-Pao-Mei-Jan-Tan on copulatory behavior was not correlated with serum T levels.

Chronic Testosterone Deprivation Sensitizes the Middle-Aged Rat Brain to Damaging Effects of Testosterone Replacement

2019 ◽  
Vol 110 (11-12) ◽  
pp. 914-928 ◽  
Author(s):  
Charity Smith ◽  
Jo Contreras-Garza ◽  
Rebecca L. Cunningham ◽  
Jessica M. Wong ◽  
Philip H. Vann ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Male Rats ◽  
Testosterone Replacement ◽  
Middle Aged ◽  
Short Term ◽  
Stress Levels ◽  
Middle Aged Male

Introduction: An increasing number of middle-aged men are being screened for low testosterone levels and the number of prescriptions for various forms of testosterone replacement therapy (TRT) has increased dramatically over the last 10 years. However, the safety of TRT has come into question with some studies suggesting increased morbidity and mortality. Objective: Because the benefits of estrogen replacement in postmenopausal women and ovariectomized rodents are lost if there is an extended delay between estrogen loss and replacement, we hypothesized that TRT may also be sensitive to delayed replacement. Methods: We compared the effects of testosterone replacement after short-term (2 weeks) and long-term testosterone deprivation (LTTD; 10 weeks) in middle-aged male rats on cerebral ischemia, oxidative stress, and cognitive function. We hypothesized that LTTD would increase oxidative stress levels and abrogate the beneficial effects of TRT. Results: Hypogonadism itself and TRT after short-term castration did not affect stroke outcome compared to intact rats. However, after long-term hypogonadism in middle-aged male Fischer 344 rats, TRT exacerbated the detrimental behavioral effects of experimental focal cerebral ischemia, whereas this detrimental effect was prevented by administration of the free-radical scavenger tempol, suggesting that TRT exacerbates oxidative stress. In contrast, TRT improved cognitive performance in non-stroked rats regardless of the length of hypogonadism. In the Morris water maze, peripheral oxidative stress was highly associated with decreased cognitive ability. Conclusions: Taken together, these data suggest that TRT after long-term hypogonadism can exacerbate functional recovery after focal cerebral ischemia, but in the absence of injury can enhance cognition. Both of these effects are modulated by oxidative stress levels.

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