scholarly journals Anti-Arthritic Evaluation of Ginger, Colchicum and Detoxified Nux-Vomica combination for Poly Herbal Unani Formulation

2021 ◽  
Vol 14 (3) ◽  
pp. 1219-1229
Author(s):  
Syed Shariq Mian ◽  
Tajuddin Tajuddin ◽  
Sukirti Upadhyay
Keyword(s):  
Dosage Form ◽  
Diclofenac Sodium ◽  
High Dose ◽  
Alcoholic Extract ◽  
Dose Ratio ◽  
Reference Drug ◽  
Adjuvant Induced Arthritis ◽  
Cotton Pellet ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant

Introduction: Arthritis (Wajaul Mafasil) is a condition which is growing worldwide due to lifestyle, environmental and genetic factors. In Unani literature, there are many herbs which are praised for treatment of Arthritis. So polyherbal formulation contains Ginger, Colchicum and Nux- Vomica is taken in combination for arthritis study. This combination is not previously reported but used by unani practitioners. Method: Three crude herbs (Ginger, Colchicum and Nux vomica) were extracted out in both aqueous and hydro-alcoholic solvent. LD-50 of all extracts (aqueous and hydro-alcoholic extract) was determined. Now respective extracts were mixed in effective dose ratio to obtain aqueous and hydro-alcoholic dosage form. Finally both effective combinations (aqueous and hydro-alcoholic) convert into tablet dosage form to determine its anti-arthritic activity by Carrageenan Induced Oedema Test, Cotton Pellet Induced Granuloma Test and Freund’s adjuvant Induced Arthritis Test. The efficacy of the Unani formulation was compared with reference drug (Diclofenac sodium). Result and Discussion: in Carrageenan Oedema Test, animals in high dose hydro-alcoholic, shows decrease in paw volume significantly after 3 hours of Carrageenan injection. In Cotton Pellet Induced Granuloma Test, animals in high dose hydro-alcoholic, shows reduction in granuloma formation significantly. In Freund’s Adjuvant Induced Arthritis Test, The significant reduction in paw volume was found in high dose hydro-alcoholic. Conclusion: Conclusively this study establishes anti-arthritic potential of polyherbal extract in unani literature. Thus these drugs possess synergistic anti-arthritic potential in combination against acute, sub-acute as well as chronic arthritis. So in future compatible dosages form may be prepared for treating arthritis.

EVALUATION OF ANTIARTHRITIC ACTIVITY OF YOGRAJ GUGGUL FORMULATION IN FREUNDS ADJUVANT INDUCED POLY-ARTHRITIC RAT MODEL

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (02) ◽  
pp. 47-53
Author(s):  
M Kaneria ◽  
◽  
G. Sharma ◽  
R. R. Wadekar ◽  
M. Pereira ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Rat Model ◽  
Capillary Permeability ◽  
Diclofenac Sodium ◽  
Reference Drug ◽  
Differential Cell Count ◽  
Connective Tissue Metabolism ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant ◽  
Hexosamine Content

The paper discusses evaluation of antiarthritic activity of Yograj guggul formulation in freund’s adjuvant induced poly-arthritis rat model. The findings demonstrate that the treatment with Yograj guggul formulation (200, 400 mg/kg/day) for 14 days produced a significant anti-arthritic activity (decreased arthritic index), inhibited connective tissue metabolism (reduced hydroxyproline and hexosamine content of edematous tissue) and caused haematological alterations (WBC, RBC, ESR and differential cell count) occur during Freund’s adjuvant induced polyarthritis in rats. The antiarthritic effect of Yograj guggul formulation at 400 mg/kg was comparable to that of reference drug, diclofenac sodium (10 mg/kg). The antiarthritic activity observed in the present study may be attributed to the various herbs present in the formulation. It is proposed that, the Yograj guggul formulation elicited antiarthritic activity largely due to the prevention of connective tissue breakdown, decreased capillary permeability and improvement of immune system.

scholarly journals Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Srinivasa Reddy Jitta ◽  
Prasanthi Daram ◽  
Karthik Gourishetti ◽  
C. S. Misra ◽  
Picheswara Rao Polu ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Complete Freund’S Adjuvant ◽  
Inflammatory Activity ◽  
Aqueous Extracts ◽  
Adjuvant Induced Arthritis ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant ◽  
Anti Inflammatory

Terminalia tomentosa bark belongs to the family Combretaceae. The plant bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis, and diarrhea. Phytochemical investigation of T. tomentosa bark confirms the presence of flavonoids, polyphenols, and tannins. The plant has not been investigated for its anti-inflammatory and antiarthritic activity. The present study was undertaken to explore its possible anti-inflammatory and antiarthritic activity. Anti-inflammatory activity of alcoholic and aqueous extracts of the bark was assessed by in vivo methods. In vivo antiarthritic potential of the extracts was evaluated by Complete Freund’s Adjuvant (CFA) induced arthritis in Wistar rats. Our findings showed that the alcoholic and aqueous extracts exhibited anti-inflammatory activity at 500 mg/kg oral dose in carrageenan-induced hind paw edema and carrageenan-induced air pouch inflammation models. We also found alcoholic as well as aqueous extracts of the bark restored the altered blood and serum parameters caused by the Complete Freund’s Adjuvant-induced arthritis in Wistar rats. This study shows that the T. tomentosa bark extracts possess anti-inflammatory activity and have pronounced effects on adjuvant arthritis also. Future studies are necessary to provide deeper insight into the exact mechanism of the action of anti-inflammatory and antiarthritic activity of T. tomentosa.

Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis

Life Sciences ◽  
2019 ◽  
Vol 226 ◽  
pp. 68-76 ◽  
Author(s):  
Kamel M. Kamel ◽  
Amany M. Gad ◽  
Suzan M. Mansour ◽  
Marwa M. Safar ◽  
Hala M. Fawzy
Keyword(s):  
Complete Freund’S Adjuvant ◽  
Adjuvant Induced Arthritis ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant
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