Microwave Assisted Synthesis of Some Substituted 1,3-diaryl Propenones and 3,5-diaryl-6-carbethoxy Cyclohexenones and their antibacterial activity

2013 ◽  
Vol 29 (2) ◽  
pp. 501-505 ◽  
Author(s):  
HARISH BABOO ◽  
SAHDEV SAHDEV
Author(s):  
Hadis Khodadad ◽  
Farhad Hatamjafari ◽  
Khalil Pourshamsian ◽  
Babak Sadeghi

Aim and Objective: Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic acid in ethanol. Materials and Methods: The structural features of the synthesized compounds were characterized by melting point, FT-IR, 1H, 13C NMR and elemental analysis. Results: The antibacterial activities of the synthesized pyrazoles was evaluated against three gram-positive bacteria such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium. Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of them demonstrated antibacterial activity against E. coli.


2011 ◽  
Vol 11 (1) ◽  
pp. S360-S363 ◽  
Author(s):  
Nishat Arshi ◽  
Faheem Ahmed ◽  
Shalendra Kumar ◽  
M.S. Anwar ◽  
Junqing Lu ◽  
...  

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